Patents by Inventor Monika Knuth

Monika Knuth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10429380
    Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: October 1, 2019
    Assignee: EyeSense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 9244064
    Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: January 26, 2016
    Assignee: EYESENSE AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 8945942
    Abstract: The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: February 3, 2015
    Assignee: Eyesense AG
    Inventors: Peter Herbrechtsmeier, Achim Müller, Monika Knuth, Katharina Nikolaus
  • Patent number: 8647271
    Abstract: An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).
    Type: Grant
    Filed: May 23, 2008
    Date of Patent: February 11, 2014
    Assignee: Eyesense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 8647699
    Abstract: The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: February 11, 2014
    Assignee: Novartis AG
    Inventors: Achim Müller, Monika Knuth, Ralf Pasternack, Jens Zotzel, Christine Reiff
  • Publication number: 20140024060
    Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to the use of a polymer-based hydrogel consisting of at least one water-soluble polymer in a sensor for enriching a dissolved glucose-binding protein, wherein the at least one water-soluble polymer is capable of interacting with the glucose-binding protein and wherein the glucose-binding protein is present in a complex with a ligand.
    Type: Application
    Filed: December 13, 2011
    Publication date: January 23, 2014
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Publication number: 20130337468
    Abstract: The present invention relates to measures for determining glucose and for diagnosing diseases based on impaired glucose metabolism. In particular the present invention relates to a device comprising a hydrogel having a glucose-binding protein and a ligand of the glucose-binding protein incorporated therein, wherein the hydrogel comprises a first hydrogel matrix made of alginate and a second hydrogel matrix which forms an interpenetrating network within the first hydrogel matrix. The invention further relates to the use of such a device for determining the glucose content in a sample and to the use of the device for diagnosing impaired glucose metabolism in a test subject.
    Type: Application
    Filed: December 13, 2011
    Publication date: December 19, 2013
    Inventors: Achim Müller, Peter Herberchtsmeier, Monika Knuth, Katharina Nikolaus
  • Publication number: 20120258551
    Abstract: The present invention relates to the use of preparations for stabilizing isolated proteins. In particular, the use of such a preparation for stabilizing receptors in biochemical sensors is disclosed. The invention in addition relates to biochemical sensors containing such preparations.
    Type: Application
    Filed: October 25, 2010
    Publication date: October 11, 2012
    Inventors: Peter Herbrechtsmeier, Achim Müller, Monika Knuth, Katharina Nikolaus
  • Publication number: 20120156361
    Abstract: The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.
    Type: Application
    Filed: February 23, 2012
    Publication date: June 21, 2012
    Inventors: Achim Müller, Monika Knuth, Ralf Pasternack, Jens Zotzel, Christine Reiff
  • Patent number: 8142835
    Abstract: The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: March 27, 2012
    Assignee: Novartis AG
    Inventors: Achim Müller, Monika Knuth, Ralf Pasternack, Jens Zotzel, Christine Reiff
  • Publication number: 20100331634
    Abstract: An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).
    Type: Application
    Filed: May 23, 2008
    Publication date: December 30, 2010
    Applicant: Eyesense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Monika Knuth, Katharina Nikolaus
  • Patent number: 7858337
    Abstract: The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.
    Type: Grant
    Filed: March 3, 2008
    Date of Patent: December 28, 2010
    Assignee: Novartis AG
    Inventors: Achim Müller, Monika Knuth, Katharina Schmid, Ralf Pasternack, Jens Zotzel, Kai Oertel, Christine Reiff, geb. Schmitt, Hans-Lothar Fuchsbauer
  • Publication number: 20090186229
    Abstract: The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.
    Type: Application
    Filed: January 21, 2009
    Publication date: July 23, 2009
    Inventors: Achim Muller, Monika Knuth, Ralf Pasternack, Jens Zotzel, Christine Reiff
  • Publication number: 20090029413
    Abstract: The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking said water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.
    Type: Application
    Filed: March 3, 2008
    Publication date: January 29, 2009
    Inventors: Achim Muller, Monika Knuth, Katharina Schmid, Ralf Pasternack, Jens Zotzel, Kai Oertel, Christine Reiff, geb. Schmitt, Hans-Lothar Fuchsbauer