Patents by Inventor Monika Lessl

Monika Lessl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzocycloheptenes, process for their production, pharmaceutical preparations that contain that latter as well as their use for the production of pharmaceutical agents
    Patent number: 7145015
    Abstract: Benzocycloheptenes of formula (I), in which R1, R2 and Y have the meanings that indicated herein, exhibit selective estrogenic activity on bones and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therapy of osteoporosis:
    Type: Grant
    Filed: April 11, 2005
    Date of Patent: December 5, 2006
    Assignee: Schering AG
    Inventors: Rolf Bohlmann, Jorg Kroll, Hermann Kuenzer, Christa Hegele-Hartung, Monika Lessl, Rosemarie Lichtner, Yukishige Nishino
  • 16-Hydroxyestratrienes as selectively active estrogens
    Publication number: 20060270845
    Abstract: The invention describes new compounds as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action on bone rather than the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds. The new compounds are 16?- and 16?-hydroxy-estra-1,3,5(10)-estratrienes, which carry additional substituents on the steroid skeleton and can have one or more additional double bonds in the B-, C- and/or D-rings.
    Type: Application
    Filed: August 3, 2006
    Publication date: November 30, 2006
    Inventors: Hermann Kuenzer, Rudolf Knauthe, Monika Lessl, Karl-Heinrich Fritzemeier, Christa Hegele-Hartung, Ulf Boemer, Gerd Mueller, Dirk Kosemund
  • Human mater proteins
    Patent number: 7125684
    Abstract: Two human MATER proteins as well as their use for fertility disorders, therapy and diagnosis are described.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: October 24, 2006
    Assignee: Schering AG
    Inventors: Bertram Weiss, Monika Lessl, Michaele Peters-Kottig, Georg Beckmann
  • 16-hydroxyestratrienes as selectively active estrogens
    Patent number: 7109360
    Abstract: The invention describes new compounds as pharmaceutical active ingredients, which have in vitro a higher affinity to estrogen receptor preparations from rat prostates than to estrogen receptor preparations from rat uteri and in vivo a preferential action on bone rather than the uterus, their production, their therapeutic use and pharmaceutical dispensing forms that contain the new compounds. The new compounds are 16?- and 16?-hydroxy-estra-1,3,5(10)-estratrienes, which carry additional substituents on the steroid skeleton and can have one or more additional double bonds in the B-, C- and/or D-rings.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: September 19, 2006
    Assignee: Schering AG
    Inventors: Hermann Kuenzer, Rudolf Knauthe, Monika Lessl, Karl-Heinrich Fritzemeier, Christa Hegele-Hartung, Ulf Boemer, Gerd Mueller, Dirk Kosemund
  • Antiestrogens, process for their production and their pharmaceutical use
    Patent number: 7074829
    Abstract: This invention relates to new antiestrogens of the general formula in which the substituents have the meanings that are explained in more detail in the description. The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens). Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.
    Type: Grant
    Filed: February 21, 2003
    Date of Patent: July 11, 2006
    Assignee: Schering AG
    Inventors: Ulrich Klar, Rolf Bohlmann, Karsten Parczyk, Karl-Heinrich Fritzemeier, Monika Lessl, Rosemarie Lichtner
  • Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents
    Publication number: 20050182081
    Abstract: Benzocycloheptenes of formula (I), in which R1, R2 and Y have the meanings that indicated herein, exhibit selective estrogenic activity on bones and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therapy of osteoporosis:
    Type: Application
    Filed: April 11, 2005
    Publication date: August 18, 2005
    Inventors: Rolf Bohlmann, Jorg Kroll, Hermann Kuenzer, Christa Hegele-Hartung, Monika Lessl, Rosemarie Lichtner, Yukishige Nishino
  • Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents
    Patent number: 6878750
    Abstract: This invention describes the new benzocycloheptenes of general formula I in which R1, R2 and SK have the meanings that are indicated in the description. The new compounds have selective estrogenic activity on bones and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therapy of osteoporosis.
    Type: Grant
    Filed: September 11, 2002
    Date of Patent: April 12, 2005
    Assignee: Schering AG
    Inventors: Rolf Bohlmann, Jorg Kroll, Hermann Kuenzer, Christa Hegele-Hartung, Monika Lessl, Rosemarie Lichtner, Yukishige Nishino
  • 11&bgr;-HALOGEN-7&agr;-SUBSTITUTED ESTRATRIENES, PROCESS FOR THE PRODUCTION OF PHARMACEUTICAL PREPARATIONS THAT CONTAIN THESE 11&bgr;-HALOGEN-7&agr;-SUBSTITUTED ESTRATRIENES AS WELL AS THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS
    Patent number: 6780855
    Abstract: This invention describes the new 11&bgr;-halogen-7&agr;-substituted estratrienes of general formula I in which R11 is a fluorine or chlorine atom, and the other substituents have the meanings that are explained in more detail in the description. The compounds have antiestrogenic properties or tissue-selective estrogenic properties and are suitable for the production of pharmaceutical agents.
    Type: Grant
    Filed: December 2, 1999
    Date of Patent: August 24, 2004
    Assignee: Schering Aktiengesellschaft
    Inventors: Rolf Bohlmann, Nikolaus Heinrich, Helmut Hofmeister, Jorg Kroll, Hermann Kunzer, Gerhard Sauer, Ludwig Zorn, Karl-Heinrich Fritzemeier, Monika Lessl, Rosemarie Lichtner, Yukishige Nishino, Karsten Parczyk, Martin Schneider
  • New antiestrogens, process for their production and their pharmaceutical use
    Publication number: 20030162830
    Abstract: This invention relates to new antiestrogens of the general formula 1
    Type: Application
    Filed: February 21, 2003
    Publication date: August 28, 2003
    Applicant: Schering Aktiengesellschaft
    Inventors: Ulrich Klar, Rolf Bohlmann, Karsten Parczyk, Karl-Heinrich Fritzemeier, Monika Lessl, Rosemarie Lichtner
  • ARL-2 for birth control
    Publication number: 20030148337
    Abstract: A human ARL-2 protein as well as its use for fertility disorders, therapy and diagnosis are described.
    Type: Application
    Filed: October 21, 2002
    Publication date: August 7, 2003
    Applicant: Schering AG
    Inventors: Monika Lessl, Michaele Peter-Kottig
  • Human mater proteins
    Publication number: 20030125282
    Abstract: Two human MATER proteins as well as their use for fertility disorders, therapy and diagnosis are described.
    Type: Application
    Filed: August 12, 2002
    Publication date: July 3, 2003
    Applicant: Schering AG
    Inventors: Bertram Weiss, Monika Lessl, Michaele Peters-Kottig, Georg Beckmann
  • Antiestrogens, process for their protection and their pharmaceutical use
    Patent number: 6559181
    Abstract: This invention relates to new antiestrogens of the general formula in which the substituents have the meanings that are explained in more detail in the description. The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens). Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.
    Type: Grant
    Filed: November 7, 2000
    Date of Patent: May 6, 2003
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Klar, Rolf Bohlmann, Karsten Parczyk, Karl-Heinrich Fritzemeier, Monika Lessl, Rosemarie Lichtner
  • 11BETA-HALOGEN-7ALPHA-SUBSTITUTED ESTRATRIENES, METOD FOR PRODUCING PHARMACEUTICAL PREPARATIONS CONTAINING SAID 11BETA-HALOGEN-7ALPHA- SUBSTITUTED ESTRATRIENES AND USE OF THE SAME FOR PRODUCING MEDICAMENTS
    Publication number: 20030069434
    Abstract: This invention describes the new 11&bgr;-halogen-7&agr;-substituted estratrienes of general formula I 1
    Type: Application
    Filed: December 2, 1999
    Publication date: April 10, 2003
    Inventors: ROLF BOHLMANN, NIKOLAUS HEINRICH, HELMUT HOFMEISTER, JORG KROLL, HERMANN KUNZER, GERHARD SAUER, LUDWIG ZORN, KARL-HEINRICH FRITZEMEIER, MONIKA LESSL, ROSEMARIE LICHTNER, YUKISHIGE NISHINO, KARSTEN PARCZYK, MARTIN SCHNEIDER
  • Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents
    Publication number: 20030050324
    Abstract: This invention describes the new benzocycloheptenes of general formula I 1
    Type: Application
    Filed: September 11, 2002
    Publication date: March 13, 2003
    Applicant: Schering AG
    Inventors: Rolf Bohlmann, Jorg Kroll, Hermann Kuenzer, Christa Hegele-Hartung, Monika Lessl, Rosemarie Lichtner, Yukishige Nishino
  • Membrane receptors for steroids and sterols
    Publication number: 20030045699
    Abstract: Four splice variants of a membrane receptor for steroids and sterols and their use are described.
    Type: Application
    Filed: April 26, 2002
    Publication date: March 6, 2003
    Inventors: Bertram Weiss, Monika Lessl, Luisella Toschi
  • Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents
    Patent number: 6495607
    Abstract: Benzocycloheptenes of general formula I in which R1, R2 and Y have the meanings indicated herein, have antiestrogenic activity on and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therapy of osteoporosis.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: December 17, 2002
    Assignee: Schering AG
    Inventors: Rolf Bohlmann, Jorg Kroll, Hermann Kuenzer, Christa Hegele-Hartung, Monika Lessl, Rosemarie Lichtner, Yukishige Nishino
  • BENZOCYCLOHEPTENES, PROCESS FOR THEIR PRODUCTION, PHARMACEUTICAL PREPARATIONS THAT CONTAIN THE LATTER AS WELL AS THEIR USE FOR THE PRODUCTION OF PHARMACEUTICAL AGENTS
    Publication number: 20020068765
    Abstract: This invention describes the new benzocycloheptenes of general formula I 1
    Type: Application
    Filed: July 19, 1999
    Publication date: June 6, 2002
    Inventors: ROLF BOHLMANN, JORG KROLL, HERMANN KUENZER, CHRISTA HEGELE-HARTUNG, MONIKA LESSL, ROSEMARIE LICHTNER, YUKISHIGE NISHINO
  • Antiestrogens, process for their production and their pharmaceutical use
    Patent number: 6166075
    Abstract: This invention relates to new antiestrogens of the general formula ##STR1## in which the substituents have the meanings that are explained in more detail in the description.The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens).Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: December 26, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Ulrich Klar, Rolf Bohlmann, Karsten Parczyk, Karl-Heinrich Fritzemeier, Monika Lessl, Rosemarie Lichtner