Patents by Inventor Monika Papworth

Monika Papworth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered O-glycosylation in recombinant polypeptides and uses thereof
    Patent number: 11834473
    Abstract: The present invention relates to recombinant polypeptide therapeutics having an engineered O-linked amino acid (AA) glycosylation sequence (motif), which is covalently linked to O-glycan(s) (tag). Recombinant O-glycosylated polypeptides may be produced in mammalian cells to present natural or un-natural O-glycan structures through metabolic labelling.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: December 5, 2023
    Assignee: MedImmune Limited
    Inventors: Adam Tibbles, Monika Papworth, Daniel Higazi, Emmanuel Rossy, Katarzyna Anna Kozakowska, Thomas Vincent Murray
  • ENGINEERED O-GLYCOSYLATION IN RECOMBINANT POLYPEPTIDES AND USES THEREOF
    Publication number: 20200317724
    Abstract: The present invention relates to recombinant polypeptide therapeutics having an engineered O-linked amino acid (AA) glycosylation sequence (motif), which is covalently linked to O-glycan(s) (tag). Recombinant O-glycosylated polypeptides may be produced in mammalian cells to present natural or un-natural O-glycan structures through metabolic labelling.
    Type: Application
    Filed: December 20, 2018
    Publication date: October 8, 2020
    Inventors: Adam Tibbles, Monika Papworth, Daniel Higazi, Emmanuel Rossy, Katarzyna Anna Kozakowska, Thomas Vincent Murray
  • Polypeptide targeting to mitochondria
    Patent number: 10596227
    Abstract: Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: March 24, 2020
    Assignee: United Kingdom Research and Innovation
    Inventors: Michal Minczuk, Monika A. Papworth, Aaron Klug
  • POLYPEPTIDE TARGETING TO MITOCHONDRIA
    Publication number: 20160199443
    Abstract: Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
    Type: Application
    Filed: September 21, 2015
    Publication date: July 14, 2016
    Inventors: Michal Minczuk, Monika A. Papworth, Aaron Klug
  • GIP AND GLP-1 RECEPTOR DUAL-AGONISTS FOR THE TREATMENT OF DIABETES
    Publication number: 20160185837
    Abstract: This disclosure provides GIP/GLP-1 dual agonist polypeptides for the treatment of hypoglycemic conditions, e.g., type-2 diabetes.
    Type: Application
    Filed: August 15, 2014
    Publication date: June 30, 2016
    Applicant: Medimmune Limited
    Inventors: Maria Bednarek, Andie Collinson, David Hornigold, Siobhan O'Brien, Monika Papworth, Peter Ravn, Isabelle Sermadiras
  • Polypeptide targeting to mitochondria
    Patent number: 9139628
    Abstract: Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
    Type: Grant
    Filed: June 23, 2008
    Date of Patent: September 22, 2015
    Assignee: Medical Research Council
    Inventors: Michal Minczuk, Monika A. Papworth, Aaron Klug
  • POLYPEPTIDE TARGETING TO MITOCHONDRIA
    Publication number: 20090186816
    Abstract: Methods for delivering non-mitochondrial proteins to mitochondria are provided. Also provided are nucleic acid constructs comprising a coding sequence encoding a DNA-binding polypeptide, fused to a mitochondrial targeting sequence (MTS) and a nuclear export signal (NES), and the encoded proteins. The construct successfully delivers DNA binding proteins to the mitochondrion. A chimeric methylase based on the above construct is successfully delivered to mitochondria, resulting in modification of mtDNA.
    Type: Application
    Filed: June 23, 2008
    Publication date: July 23, 2009
    Inventors: Michal Minczuk, Monika A. Papworth, Aaron Klug