Abstract: The present disclosure pertains to a particulate co-processed pre-formulated excipient composition and methods for producing the same. In particular, the present disclosure provides a particulate co-processed pre-formulated excipient composition for enhancing dissolution rate of poorly soluble active pharmaceutical ingredient, wherein said excipient composition comprises a co-processed mixture of a filler-binder, a glidant, a disintegrant, a solubility enhancer, and a lubricant. The co-processed pre-formulated excipient composition has higher bulk density, bigger particle size, excellent flowability, good physical properties of excipient delivered good quality of tablet in terms tablet hardness, disintegration time and dissolution rate.

Abstract: The present invention relates, in part, to novel compounds comprising 4-imidazolidinone-fused cyclic peptides and compositions thereof. The present invention also relates to methods of generating said compounds and compositions thereof as well as methods of inhibiting protein-protein interaction using said compounds or compositions thereof. In another aspect, the present invention relates, in part, to methods of treating or preventing a various diseases or disorders using said compounds or compositions thereof.

Abstract: The present invention relates to ligation agents and their use in making an amide ligation product. Methods of making the ligation agents are also disclosed.

Abstract: The present invention relates to ligation agents and their use in making an amide ligation product. Methods of making the ligation agents are also disclosed.

Abstract: The present invention relates to ligation agents and their use in making an amide ligation product. Methods of making the ligation agents are also disclosed.