Patents by Inventor Monika Singer

Monika Singer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11155852
    Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: October 26, 2021
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
  • Publication number: 20180346964
    Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.
    Type: Application
    Filed: July 23, 2018
    Publication date: December 6, 2018
    Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
  • Patent number: 10059980
    Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.
    Type: Grant
    Filed: January 22, 2014
    Date of Patent: August 28, 2018
    Assignee: ROCHE MOLECULAR SYSTEMS, INC.
    Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
  • Publication number: 20150353992
    Abstract: The present invention refers to a method for immuno-histochemical staining of a formalin-fixed, paraffin-embedded tissue section comprising the steps of a) providing a solid support, b) mounting the formalin-fixed, paraffin-embedded tissue section onto the solid support, c) removing the paraffin from the formalin-fixed, paraffin-embedded tissue section, d) heating the tissue section mounted on the solid support to retrieve epitopes at 50 to 70° C. for 12 to 24 h, and e) staining the tissue section mounted on the solid support, wherein at least step e) is performed in the presence of 0.5 to 3.0 M sodium chloride. The present invention further refers to a kit for performing the method.
    Type: Application
    Filed: January 22, 2014
    Publication date: December 10, 2015
    Inventors: Beatrix Bahle, Andrea Herold, Sabine Lohmann, Sabine Moosmann, Julian Schuster, Monika Singer
  • Patent number: 7343507
    Abstract: An input circuit (1?) provided with a time delay element (40), which circuit is capable of being tested by a controlled high level or low level connection, and a method for the operation thereof. The delay time of the time-delay element can be modified during operation of the input circuit. In particular, the elapsed delay time is read out prior to the testing of the input circuit and is restored again after testing, so that the test does not increase the effective input delay time for the process signals. In addition or as an alternative, the delay time is set to a minimum value prior to the test to enable rapid testing of the input circuit independent of the set delay time.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: March 11, 2008
    Assignee: Siemens Aktiengesellschaft
    Inventors: Stefan Grosser, Mario Maier, Reinhard Mark, Monika Singer
  • Publication number: 20050030682
    Abstract: An input circuit (1?) provided with a time delay element (40), which circuit is capable of being tested by a controlled high level or low level connection, and a method for the operation thereof. The delay time of the time-delay element can be modified during operation of the input circuit. In particular, the elapsed delay time is read out prior to the testing of the input circuit and is restored again after testing, so that the test does not increase the effective input delay time for the process signals. In addition or as an alternative, the delay time is set to a minimum value prior to the test to enable rapid testing of the input circuit independent of the set delay time.
    Type: Application
    Filed: July 7, 2004
    Publication date: February 10, 2005
    Inventors: Stefan Grosser, Mario Maier, Reinhard Mark, Monika Singer