Patents by Inventor Monika Uhlein

Monika Uhlein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Determination of short-chain SRL alcohol dehydrogenase (DHRS4) as a biomarker for inflammations and infections
    Patent number: 8183004
    Abstract: The present invention relates to the use of short-chain SRL alcohol dehydrogenase (DHRS4, SEQ ID NO: 1) and peptides thereof as humoral biomarkers for the diagnostic detection and prognosis of the course, and also monitoring the course and therapy of septic inflammations and infections.
    Type: Grant
    Filed: March 6, 2006
    Date of Patent: May 22, 2012
    Assignee: B.R.A.H.M.S GmbH
    Inventors: Andreas Bergmann, Joachim Struck, Monika Uhlein
  • DETERMINATION OF SHORT-CHAIN SRL ALCOHOL DEHYDROGENASE (DHRS4) AS A BIOMARKER FOR INFLAMMATIONS AND INFECTIONS
    Publication number: 20090136973
    Abstract: The present invention relates to the use of short-chain SRL alcohol dehydrogenase (DHRS4, SEQ ID NO: 1) and peptides thereof as humoral biomarkers for the diagnostic detection and prognosis of the course, and also monitoring the course and therapy of septic inflammations and infections.
    Type: Application
    Filed: March 6, 2006
    Publication date: May 28, 2009
    Applicant: B.R.A.H.M.S AKTIENGESELLSCHAFT
    Inventors: Andreas Bergmann, Joachim Struck, Monika Uhlein
  • Diagnosis of Sepsis by the Selective Determination of the Concentration of Cu/Zn Superoxide Dismutase (Cu/Zn Sod) in Patient Samples
    Publication number: 20090011431
    Abstract: The present invention relates to a method for the early determination of the risk of mortality of patients in intensive care units or emergency care units during which the concentration of Cu/Zn superoxide dismutase (Cu/Zn SOD) in a serum sample or plasma sample of the patient is selectively determined, and quantitatively or semi-quantitatively measured concentrations, which exceed a predetermined threshold value are correlated with a high risk of mortality.
    Type: Application
    Filed: February 2, 2005
    Publication date: January 8, 2009
    Applicant: B.R.A.H.M.S AKTIENGESELLSCHAFT
    Inventors: Andreas Bergmann, Joachim Struck, Monika Uhlein, Nils G. Morgenthaler
  • Uses of carbamoyl phosphate synthetase for the diagnois of inflammatory diseases and sepsis
    Patent number: 7413850
    Abstract: Use of carbamoyl phosphate synthetase 1 (CPS 1) and/or of fragments of the N-terminal part of CPS 1 from body fluids or body tissues as marker peptides for the diagnosis and for the prognosis and the monitoring of inflammations and infections, including sepsis, and of liver failure as part of multiorgan failure or for determinations in connection with inflammatory and other liver diseases.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: August 19, 2008
    Assignee: B.R.A.H.M.S. Aktiengesellschaft
    Inventors: Andreas Bergmann, Joachim Struck, Monika Uhlein
  • USES OF CARBAMOYL PHOSPHATE SYNTHETASE 1 (CPS 1) AND IT'S FRAGMENTS FOR THE DIAGNOSIS OF LIVER DISEASES
    Publication number: 20080176259
    Abstract: Use of carbamoyl phosphate synthetase 1 (CPS 1) and/or of fragments of the N-terminal part of CPS 1 from body fluids or body tissues as marker peptides for the diagnosis and for the prognosis and the monitoring of inflammations and infections, including sepsis, and of liver failure as part of multiorgan failure or for determinations in connection with inflammatory and other liver diseases.
    Type: Application
    Filed: February 29, 2008
    Publication date: July 24, 2008
    Applicant: B.R.A.H.M.S. Aktiengesellschaft
    Inventors: Andreas Bergmann, Joachim Struck, Monika Uhlein
  • CHP for use as marker for sepsis-type inflammatory diseases
    Patent number: 7235368
    Abstract: Use of calcineurin B homologous protein (CHP) from body fluids or body tissues as a marker peptide for diagnosis, for prognosis and for monitoring the course of inflammations and infections and/or as a target for therapeutically influencing the course of inflammations and/or infections.
    Type: Grant
    Filed: June 17, 2002
    Date of Patent: June 26, 2007
    Assignee: B.R.A.H.M.S Aktiengesellschaft
    Inventors: Andreas Bergmann, Joachim Struck, Monika Ühlein
  • Uses of aldose-1-epimerase (mutarotase) for diagnosis and therapy of inflammatory diseases and sepsis
    Patent number: 7157081
    Abstract: Uses of aldose 1-epimerase (SEQ ID NO:3) from body fluids or body tissues in human and veterinary medicine as a marker peptide for diagnosis, for prognosis of the course and for monitoring of the course of inflammations and infections and/or as a target for therapeutically influencing the course of inflammations and/or infections.
    Type: Grant
    Filed: November 29, 2002
    Date of Patent: January 2, 2007
    Assignee: B.R.A.H.M.S Aktiengesellschaft
    Inventors: Andreas Bergmann, Joachim Struck, Monika Ühlein
  • Inflammation-specific peptides and the uses thereof
    Patent number: 7153662
    Abstract: The invention relates to novel peptides and partial peptide sequences for the diagnosis and therapy of inflammations and sepsis, which are formed in the case of inflammations and/or infections of primates and humans, and their use or the use of antibodies formed against these peptides in diagnosis and therapy.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: December 26, 2006
    Assignee: B.R.A.H.M.S. Aktiengesellschaft
    Inventors: Andreas Bergmann, Joachim Struck, Monika Ühlein
  • Use of soluble cytokeratin-1-fragments in diagnostics and therapy
    Patent number: 7132246
    Abstract: Use of novel soluble cytokeratin 1 fragments from body fluids or body tissues as marker peptides for the diagnosis, prognosis and monitoring of the course of inflammations and infections and/or as a target for the therapeutic influencing of the course of inflammations and/or infections.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: November 7, 2006
    Inventors: Andreas Bergmann, Joachim Struck, Monika Ühlein
  • Uses of carbamoyl phosphate synthetas for the diagnosis of inflammatory diseases and sepsis
    Publication number: 20060115869
    Abstract: Use of carbamoyl phosphate synthetase 1 (CPS 1) and/or of fragments of the N-terminal part of CPS 1 from body fluids or body tissues as marker peptides for the diagnosis and for the prognosis and the monitoring of inflammations and infections, including sepsis, and of liver failure as part of multiorgan failure or for determinations in connection with inflammatory and other liver diseases.
    Type: Application
    Filed: April 15, 2003
    Publication date: June 1, 2006
    Applicant: B.R.A.H.M.S Aktiengesellschaft
    Inventors: Andreas Bergmann, Joachim Struck, Monika Uhlein
  • Use of the glycine n-acyl transferase (gnat) for the diagnosis and therapy of inflammatory diseases and sepsis
    Publication number: 20060035221
    Abstract: Uses of glycine N-acyltransferase (GNAT) from body fluids or body tissues in human and veterinary medicine as a marker peptide for diagnosis, for prognosis and for monitoring the course of inflammations and infections and/or as a target for therapeutically influencing the course of inflammations and/or infections.
    Type: Application
    Filed: November 29, 2002
    Publication date: February 16, 2006
    Applicant: B.R.A.H.M.S Aktiengesellschaft
    Inventors: Andreas Bergmann, Joachim Struck, Monika Uhlein
  • Uses of aldose-1-epimerase (mutarotase) for diagnosis and therapy of inflammatory diseases and sepsis
    Publication number: 20050130242
    Abstract: Uses of aldose 1-epimerase (SEQ ID NO:3) from body fluids or body tissues in human and veterinary medicine as a marker peptide for diagnosis, for prognosis of the course and for monitoring of the course of inflammations and infections and/or as a target for therapeutically influencing the course of inflammations and/or infections.
    Type: Application
    Filed: November 29, 2002
    Publication date: June 16, 2005
    Applicant: B.R.A.H.M.S. Aktiengesellschaft
    Inventors: Andreas Bergmann, Joachim Struck, Monika Uhlein
  • Chp for use as marker for sepsis-type inflammatory diseases
    Publication number: 20050064409
    Abstract: Use of calcineurin B homologous protein (CHP) from body fluids or body tissues as a marker peptide for diagnosis, for prognosis and for monitoring the course of inflammations and infections and/or as a target for therapeutically influencing the course of inflammations and/or infections.
    Type: Application
    Filed: June 17, 2002
    Publication date: March 24, 2005
    Inventors: Andreas Bergmann, Joachim Struck, Monika Uhlein
  • Use of soluble cytokeratin-1-fragments in diagnostics and therapy
    Publication number: 20040219597
    Abstract: Use of novel soluble cytokeratin 1 fragments from body fluids or body tissues as marker peptides for the diagnosis, prognosis and monitoring of the course of inflammations and infections and/or as a target for the therapeutic influencing of the course of inflammations and/or infections.
    Type: Application
    Filed: June 1, 2004
    Publication date: November 4, 2004
    Inventors: Andreas Bergmann, Joachim Struck, Monika Uhlein
  • Inflammation-specific peptides and the uses thereof
    Publication number: 20040214229
    Abstract: The invention relates to novel peptides and partial peptide sequences for the diagnosis and therapy of inflammations and sepsis, which are formed in the case of inflammations and/or infections of primates and humans, and their use or the use of antibodies formed against these peptides in diagnosis and therapy.
    Type: Application
    Filed: May 13, 2004
    Publication date: October 28, 2004
    Inventors: Andreas Bergamnn, Joachim Struck, Monika Uhlein