Abstract: A computer-implemented method comprising: receiving information indicative of a keyword; receiving information indicative of a domain of interest; identifying, by one or more computer systems, a predefined number of search results for the keyword, with the identified search results having increased ranking scores, relative to other ranking scores of other search results for the keyword; determining, by the or more computer systems, from the search results a ranking score of a search result that is for the keyword and that is associated with the domain of interest; and transmitting, to a computing device that sent the information indicative of the domain of interest, information indicative of the identified search results with the increased ranking scores and information indicative of the ranking of the search result that is associated with the domain of interest.

Abstract: A computer-implemented method comprising: receiving information indicative of a keyword; receiving information indicative of a domain of interest; identifying, by one or more computer systems, a predefined number of search results for the keyword, with the identified search results having increased ranking scores, relative to other ranking scores of other search results for the keyword; determining, by the or more computer systems, from the search results a ranking score of a search result that is for the keyword and that is associated with the domain of interest; and transmitting, to a computing device that sent the information indicative of the domain of interest, information indicative of the identified search results with the increased ranking scores and information indicative of the ranking of the search result that is associated with the domain of interest.

Abstract: The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides, nitrones, azides, nitrile ylide diazoalkane, nitrile imide, ozone, azomethine imides, azomethine ylides etc. with exocyclic double bond of C ring (?-methylene-?-butyrolactone). Representative compounds have been screened for their anticancer activity against different cancer cell lines. ICs0 value of these analogues varies between 4.3 ?M to 93 ?M. A mechanistic correlation of their anticancer activity has been described. The results of the cytotoxicity test of the compounds studies indicated that the ?,?-unsaturated ketonic moiety in parthenin plays an important role in the maintenance of the high level of cytotoxicity.

Abstract: The present invention relates to novel spiro derivatives of parthenin prepared by the dipolar cycloaddition of various dipoles viz, benzonitrile oxides, nitrones, azides, nitrile ylide diazoalkane, nitrile imide, ozone, azomethine imides, azomethine ylides etc. with exocyclic double bond of C ring (?-methylene-?-butyrolactone). Representative compounds have been screened for their anticancer activity against different cancer cell lines. ICs0 value of these analogues varies between 4.3 ?M to 93 ?M. A mechanistic correlation of their anticancer activity has been described. The results of the cytotoxicity test of the compounds studies indicated that the ?,?-unsaturated ketonic moiety in parthenin plays an important role in the maintenance of the high level of cytotoxicity.

Abstract: The present invention relates to use of compounds of general formula 1 for anticancerous activity, wherein the said compound being derived semi-synthetically from natural triterpenoic acids known as boswellic acids by the induction of apoptosis thereof cytotoxicity and anti-cancer activity displayed by semi-synthetic analogues of natural triterpenes, known as Boswellic acids. These compounds may be used for the treatment of cancer, alone or in combination with pharmaceutically acceptable or other carriers, displaying cytotoxicity and anti-cancer activity for colon, prostrate, liver, breast, central nervous system (CNS), leukemia and malignancy of other tissues, including ascites and solid tumors. The cancer cell death is mediated by induction of apoptosis and inhibition of cell proliferation at specific doses.