Patents by Inventor Monika Weirdl

Monika Weirdl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition and method for inhibiting tumor cell growth
    Patent number: 9492510
    Abstract: Polynucleotides encoding a secreted mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: November 15, 2016
    Assignees: St. Jude Children's Research Hospital, The University of North Carolina
    Inventors: Philip M. Potter, Monika Weirdl, Matthew R. Redinbo
  • Method for sensitizing tumor cells to chemotherapeutic prodrug CPT-11
    Patent number: 9068174
    Abstract: Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.
    Type: Grant
    Filed: January 24, 2012
    Date of Patent: June 30, 2015
    Assignees: St. Jude Children's Research Hospital, The University of North Carolina
    Inventors: Philip M. Potter, Monika Weirdl, Matthew R. Redinbo
  • COMPOSITION AND METHOD FOR INHIBITING TUMOR CELL GROWTH
    Publication number: 20150157696
    Abstract: Polynucleotides encoding a secreted mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.
    Type: Application
    Filed: February 3, 2015
    Publication date: June 11, 2015
    Inventors: Philip M. Potter, Monika Weirdl, Matthew R. Redinbo
  • Compositions For Treating Bacterial Infections
    Publication number: 20120142108
    Abstract: Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.
    Type: Application
    Filed: January 24, 2012
    Publication date: June 7, 2012
    Inventors: Philip M. Potter, Monika Weirdl, Matthew R. Redinbo
  • Compositions and methods for inducing or inhibiting activities of selected human cells
    Patent number: 8124393
    Abstract: Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.
    Type: Grant
    Filed: February 4, 2011
    Date of Patent: February 28, 2012
    Assignees: St. Jude Children's Research Hospital, The University of North Carolina
    Inventors: Philip M. Potter, Monika Weirdl, Matthew R. Redinbo
  • Compositions for treating bacterial infections
    Publication number: 20110165141
    Abstract: Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.
    Type: Application
    Filed: February 4, 2011
    Publication date: July 7, 2011
    Applicants: St. Jude Children's Research Hospital, The University of North Carolina at Chapel Hill
    Inventors: Philip M. Potter, Monika Weirdl, Matthew R. Redinbo
  • Compositions and methods for inducing or inhibiting activities of selected human cells
    Patent number: 7906637
    Abstract: Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.
    Type: Grant
    Filed: June 20, 2007
    Date of Patent: March 15, 2011
    Assignees: St. Jude Children's Research Hospital, The University of North Carolina at Chapel Hill
    Inventors: Philip M. Potter, Monika Weirdl, Matthew R. Redinbo
  • Compositions and Methods for Inducing or Inhibiting Activities of Selected Human Cells
    Publication number: 20090275510
    Abstract: Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells to a prodrug agent, inhibiting cell growth, treating drug addiction, and facilitating the metabolism of an organophosphate with this enzyme are also provided. In addition, a screening assay for identification of drugs activated by this enzyme is described.
    Type: Application
    Filed: June 20, 2007
    Publication date: November 5, 2009
    Inventors: Philip M. Potter, Monika Weirdl, Mattehew R. Redinbo