Patents by Inventor Monique L. Howard

Monique L. Howard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of anchoring protein function
    Patent number: 6107104
    Abstract: The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA. Another aspect of the present invention is methods for enhancing expression of interleukin 2 by T cells. Further provided are methods to identify proteins which interact with AKAP 79, and methods to identify inhibitors of AKAP 79 interaction with other proteins.
    Type: Grant
    Filed: September 27, 1996
    Date of Patent: August 22, 2000
    Assignee: ICOS Corporation
    Inventors: Robert Owen Lockerbie, Monique L. Howard, W. Michael Gallatin, Yvonne Lai
  • Modulators of anchoring protein function
    Patent number: 5871945
    Abstract: The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA. Another aspect of the present invention is methods for enhancing expression of interleukin 2 by T cells.
    Type: Grant
    Filed: July 17, 1995
    Date of Patent: February 16, 1999
    Assignee: ICOS Corporation
    Inventors: Robert Owen Lockerbie, Monique L. Howard, W. Michael Gallatin
  • Calcineurin inhibitory compounds and anchoring protein
    Patent number: 5807693
    Abstract: The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: September 15, 1998
    Assignees: ICOS Corporation, The State of Oregon, acting by and through the Oregon State Board of Higher Education, and on Behalf of the Oregon Health Science University
    Inventors: John D. Scott, Vincent M. Coghlan, Monique L. Howard, William M. Gallatin
  • Calcineurin inhibitory compounds and anchoring protein to induce IL-2 gene expression
    Patent number: 5744354
    Abstract: The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA. Another aspect of the present invention is methods for enhancing expression of interleukin 2 by T cells.
    Type: Grant
    Filed: March 15, 1995
    Date of Patent: April 28, 1998
    Assignees: ICOS Corporation, The State of Oregon, acting by and through the Oregon State Board of Higher Education, and on behalf of Oregon Health Sciences University
    Inventors: Robert Owen Lockerbie, John D. Scott, Vincent M. Coghlan, Monique L. Howard, W. Michael Gallatin
  • Calcineurin inhibitory compounds and anchoring protein
    Patent number: 5629163
    Abstract: The present invention provides compositions and methods useful for isolating calcineurin as well as inhibiting calcineurin activity. The compositions are peptides that contain regions that are homologous to calcineurin-binding regions of AKAP 79. Also provided are methods for determining if a cell contains a calcineurin-binding and PKA-binding anchoring protein that are useful for identifying additional proteins that bind both calcineurin and PKA.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: May 13, 1997
    Assignees: ICOS Corporation, The State of Oregon acting by and through the Oregon State Board of Higher Education and on behalf of Oregon Health Sciences University
    Inventors: John D. Scott, Vincent M. Coghlan, Monique L. Howard, William M. Gallatin