Patents by Inventor Monroe E. Wall

Monroe E. Wall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Camptothecin analogs having an E-ring ketone
    Patent number: 7071204
    Abstract: Camptothecin analogs having an E-ring ketone are effective anti tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I DNA cleavable complex.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: July 4, 2006
    Assignee: Research Triangle Institute
    Inventors: Michael A. Wall, Mansukh C. Wani, Govindarajan Manikumar, Monroe E. Wall
  • 7-substituted camptothecin and camptothecin analogs and methods for producing the same
    Patent number: 7067666
    Abstract: Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: June 27, 2006
    Assignee: Research Triangle Institute
    Inventors: Mansukh C. Wani, Govindarajan Manikumar, Michael A. Wall, Monroe E. Wall
  • 7-Substituted camptothecin and camptothecin analogs and methods for producing the same
    Publication number: 20040266803
    Abstract: Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
    Type: Application
    Filed: June 27, 2003
    Publication date: December 30, 2004
    Applicant: Research Triangle Insitute
    Inventors: Mansukh C. Wani, Govindarajan Manikumar, Monroe E. Wall, Michael A. Wall
  • Camptothecin analogs having an E-ring ketone
    Publication number: 20040266804
    Abstract: Camptothecin analogs having an E-ring ketone are effective anti tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I DNA cleavable complex.
    Type: Application
    Filed: June 30, 2003
    Publication date: December 30, 2004
    Applicant: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Michael A. Wall
  • Camptothecin compounds with a thioether group
    Patent number: 6825206
    Abstract: Camptothecin compounds which are effective anti-tumor compounds are disclosed. These conjugates inhibit the enzyme topoisomerase I and enhance the stability of the topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: November 30, 2004
    Assignees: Research Triangle Institute, Duke University, National Institutes of Health
    Inventors: Michael P. Gamcsik, David J. Adams, O. Michael Colvin, Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Yves Pommier
  • Camptothecin &bgr;-alanine esters with topoisomerase I inhibition
    Patent number: 6288072
    Abstract: &bgr;-Alanine esters of camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: September 11, 2001
    Inventors: Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Neelakantan Balasubramanian, Dolatrai Vyas
  • 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition
    Patent number: 6268375
    Abstract: Camptothecin compounds having a C10 11 O—(CF2)nO group where n is 1 or 2 are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: July 31, 2001
    Assignees: Research Triangle Institute, Bristol-Myers Squibb Company
    Inventors: Monroe E. Wall, Mansukh C. Wani, Govindarajan Manikumar, Neelakantan Balasubramanian, Dolatrai Vyas
  • Water-soluble esters of camptothecin compounds
    Patent number: 6040313
    Abstract: Non-toxic camptothecin prodrugs are prepared by esterifying the 20-position hydroxyl group of camptothecin derivatives.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: March 21, 2000
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani
  • Camptothecin compounds with combined topoisomarase I inhibition and DNA alkylation properties
    Patent number: 5985888
    Abstract: Camptothecin compounds having a --CH.sub.2 --L group are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and DNA of associated topoisomerase I-DNA complexes.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: November 16, 1999
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani
  • Camptothecin compounds with combined topoisomerase I inhibition and DNA alkylation properties
    Patent number: 5932588
    Abstract: Camptothecin compounds having a --CH.sub.2 --L group are effective anti-tumor compounds. These compounds inhibit the enzyme topoisomerase I and DNA of associated topoisomerase I-DNA complexes.
    Type: Grant
    Filed: October 8, 1997
    Date of Patent: August 3, 1999
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani
  • Water-soluble esters of camptothecin compounds
    Patent number: 5916896
    Abstract: Non-toxic camptothecin prodrugs are prepared by esterifying the 20-position hydroxyl group of camptothecin derivatives.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: June 29, 1999
    Assignee: Research Triange Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani
  • Water-soluble esters of camptothecin compounds
    Patent number: 5646159
    Abstract: Non-toxic camptothecin prodrugs are prepared by esterifying the 20-position hydroxyl group of camptothecin derivatives.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: July 8, 1997
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani
  • Inhibition of plasmodia parasites by camptothecin compounds
    Patent number: 5614529
    Abstract: Camptothecin compounds are effective inhibitors of plasmodia growth and are useful in treating plasmodia infections in livestock, other domestic animals and humans.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: March 25, 1997
    Assignees: Research Triangle Institute, Robert R. Engle, Robert E. Miller
    Inventors: Monroe E. Wall, Mansukh C. Wani, Robert R. Engle, Robert E. Miller
  • Inhibition of hemoflagellates by camptothecin compounds
    Patent number: 5496830
    Abstract: Camptothecin compounds are effective inhibitors of hemoflagellate growth and are useful in treating leishmaniasis and trypanosomiasis in livestock, other domestic animals and humans.
    Type: Grant
    Filed: September 14, 1994
    Date of Patent: March 5, 1996
    Assignees: Johns Hopkins University, Research Triangle Institute
    Inventors: Theresa A. Shapiro, Annette L. Bodley, Monroe E. Wall, Mansukh C. Wani
  • Alkyl camptothecin compounds as potent inhibitors of human colorectal cancer
    Patent number: 5401747
    Abstract: A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase. I and show antileukemic and anti-tumor activity.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: March 28, 1995
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani, Allan W. Nicholas, Govindarajan Manikumar
  • Camptothecin analogs as potent inhibitors of topoisomerase I
    Patent number: 5364858
    Abstract: A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase.I and show antileukemic and anti-tumor activity.
    Type: Grant
    Filed: December 8, 1992
    Date of Patent: November 15, 1994
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani, Allan W. Nicholas, Govindarajan Manikumar
  • Method of treating tumors with anti-tumor effective camptothecin compounds
    Patent number: 5340817
    Abstract: A camptothecin analog having the structure shown below: ##STR1## where Z is H or C.sub.1-8 alkyl and R is NO.sub.2, NH.sub.2, N.sub.3, hydrogen, halogen, COOH, OH, O-C.sub.1-3 alkyl, SH, S-C.sub.1-3 alkyl, CN, CH.sub.2 NH.sub.2, NH-C.sub.1-3 alkyl, CH.sub.2 -NH-C.sub.1-3 alkyl, N(C.sub.1-3 alkyl).sub.2, CH.sub.2 N(C.sub.1-3 alkyl).sub.2, O-, NH- or S-CH.sub.2 CH.sub.2 N(CH.sub.2 CH.sub.2 OH).sub.2, O-, NH- or S- CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.2 CH.sub.2 OH).sub.2, O-, NH- or S-CH.sub.2 CH.sub.2 N(CH.sub.2 CH.sub.2 CH.sub.2 OH).sub.2, O-, NH- or S-CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.2 CH.sub.2 OH.sub.2).sub.2, O-, NH- or S-CH.sub.2 CH.sub.2 N(C.sub.1-3 alkyl).sub.2, O-, NH- or S-CH.sub.2 CH.sub.2 CH.sub.2 N(C.sub.1-3 alkyl).sub.2, CHO, C.sub.1-3 alkyl or NHCOCHR.sup.1 NR.sup.2 R.sup.3, where R.sup.1 is the side-chain of an .alpha.-amino acid and R.sup.2 and R.sup.3, independently are hydrogen or a lower alkyl group or R.sup.
    Type: Grant
    Filed: June 17, 1992
    Date of Patent: August 23, 1994
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani, Allan W. Nicholas, Govindarajan Manikumar
  • Camptothecin analogs as potent inhibitors of topoisomerase I
    Patent number: 5244903
    Abstract: A method for synthesizing camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase.
    Type: Grant
    Filed: October 22, 1990
    Date of Patent: September 14, 1993
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani, Allan W. Nicholas, Govindarajan Manikumar
  • Pharmaceutical compositions and methods employing camptothecins
    Patent number: 5227380
    Abstract: A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase I and show antileukemic and anti-tumor activity.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: July 13, 1993
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani, Allan W. Nicholas, Govindarajan Manikumar
  • 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
    Patent number: 5180722
    Abstract: A camptothecin analog having the structure shown below: ##STR1## where Z is H or C.sub.1-8 alkyl and R is NO.sub.2, NH.sub.2, N.sub.3, hydrogen, halogen, COOH, OH, O--C.sub.1-3 alkyl, SH, S--C.sub.1-3 alkyl, CN, CH.sub.2 NH.sub.2, NH--C.sub.1-3 alkyl, CH.sub.2 --NH--C.sub.1-3 alkyl, N(C.sub.1-3 alkyl).sub.2, CH.sub.2 N(C.sub.1-3 alkyl).sub.2, O--, NH--, or S--CH.sub.2 CH.sub.2 N(CH.sub.2 CH.sub.2 OH).sub.2, O--, NH-- or S-- CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.2 CH.sub.2 OH).sub.2, O--, NH-- or S--CH.sub.2 CH.sub.2 N(CH.sub.2 CH.sub.2 CH.sub.2 OH).sub.2, O--, NH-- or S--CH.sub.2 CH.sub.2 CH.sub.2 N(CH.sub.2 CH.sub.2 CH.sub.2 OH.sub.2).sub.2, O--, NH-- or S--CH.sub.2 CH.sub.2 N(C.sub.1-3 alkyl).sub.2, O--, NH-- or S--CH.sub.2 CH.sub.2 CH.sub.2 N(C.sub.1-3 alkyl).sub.2, CHO, C.sub.1-3 alkyl or NHCOCHR.sup.1 NR.sup.2 R.sup.3, where R.sup.1 is the side-chain of an .alpha.-amino acid and R.sup.2 and R.sup.3, independently are hydrogen or a lower alkyl group or R.sup.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: January 19, 1993
    Assignee: Research Triangle Institute
    Inventors: Monroe E. Wall, Mansukh C. Wani, Allan W. Nicholas, Govindarajan Manikumar