Abstract: A process for preparing a transdermal drug delivery device includes preparing a polymer matrix by homogenizing about 7 weight % sodium alginate with about 3.5 weight % glycerol for about 5 minutes, mixing with about 0.5 weight % nicotine in about 89 weight % distilled water, casting the mixture over a backing material and drying overnight, and spraying with an about 5 weight % solution of calcium ions to cross-link. A control release membrane is prepared by homogenizing about 3.1 weight % of sodium alginate with about 3.6 weight % of glycerol for about 5 minutes, mixing with about 93.3 weight % of distilled water, casting the mixture over a backing material and drying overnight, and spraying with an about 5 weight % solution of calcium ions to cross-link. And, the drug delivery device is assembled by cutting a circle of the polymer matrix and a circle of the control release membrane and assembling them in sequence on a piece of backing material.

Abstract: Solid pharmaceutical slow release dosage forms of dihydropyridines such as nifedipine or nimodipine are manufactured by dissolving the dihydropyridine and polyvinylpyrollidone (PVP) in a solvent, adding colloidal silicon dioxide stepwise to the resultant viscous liquid until a granular mass is formed, drying the mass, and blending the product with an excipient.