Patents by Inventor Mony De Leon

Mony De Leon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10945685
    Abstract: Systems and methods are for analyzing Positron Emission Tomography (PET) image data. The methods may include generating a set of standardized uptake values (SUVs) of global or localized PET data for voxels within a selected region of interest (ROI), normalizing the set of SUVs by generating a set of SUVPs where each corresponding SUVP for each SUV is obtained using the formula: SUVP=(SUV?M)/S, wherein M corresponds to a peak value for the set of SUVs, and S corresponds to a spread for the set of SUVs, and generating a normalized image based on the set of SUVPs for the ROI. The systems may include any suitable device for PET image analysis performing the methods.
    Type: Grant
    Filed: July 24, 2019
    Date of Patent: March 16, 2021
    Assignee: New York University
    Inventors: Yi Li, Jingyun Chen, Mony De Leon
  • Publication number: 20200029918
    Abstract: Systems and methods are for analyzing Positron Emission Tomography (PET) image data. The methods may include generating a set of standardized uptake values (SUVs) of global or localized PET data for voxels within a selected region of interest (ROI), normalizing the set of SUVs by generating a set of SUVPs where each corresponding SUVP for each SUV is obtained using the formula: SUVP=(SUV?M)/S, wherein M corresponds to a peak value for the set of SUVs, and S corresponds to a spread for the set of SUVs, and generating a normalized image based on the set of SUVPs for the ROI. The systems may include any suitable device for PET image analysis performing the methods.
    Type: Application
    Filed: July 24, 2019
    Publication date: January 30, 2020
    Inventors: Yi Li, Jingyun Chen, Mony De Leon
  • Publication number: 20160139150
    Abstract: The present invention provides methods for diagnosing a neurological disease in a subject, screening for or assessing the risk of developing a neurological disease in a subject, monitoring progression of a neurological disease in a subject, assessing efficacy of a therapy for a neurological disease in a subject, and identifying a subject suffering from a neurological disease that may be successfully treated by an agent that affects levels of a biomarker such as a tau protein or an amyloid beta. The methods generally feature (a) obtaining a cerebrospinal fluid (CSF) sample from a subject; (b) providing a cerebrospinal fluid (CSF) correction factor for CSF obtained from a subject for at least one biomarker; and (c) determining whether the biomarker is present in elevated amounts or concentrations in the cerebrospinal fluid (CSF) sample. The neurological disease may be, for instance, impaired cognition or dementia such as Alzheimer's Disease (AD) or Mild Cognitive Impairment (MCI).
    Type: Application
    Filed: September 10, 2014
    Publication date: May 19, 2016
    Inventors: Mony de Leon, Henry Rusinek
  • Publication number: 20130310682
    Abstract: A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anatomical protocols, determining a measurement of biomarker levels in CSF that has been extracted, correcting the measurement of the level of said at least one biomarker according to the ventricular size, and providing a corrected result of the measurement determined in step (b), said corrected result accounting for concentration dilution due to the change in ventricular size. The method is particularly suited for the measurement of all biomarkers found in the CSF, such as those associated with mild cognitive impairment (MCI) and Alzheimer's Disease.
    Type: Application
    Filed: July 29, 2013
    Publication date: November 21, 2013
    Applicant: NEW YORK UNIVERSITY
    Inventors: Mony de Leon, Henry Rusinek
  • Publication number: 20120191360
    Abstract: A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anatomical protocols, determining a measurement of biomarker levels in CSF that has been extracted, correcting the measurement of the level of said at least one biomarker'according to the ventricular size, and providing a corrected result of the measurement determined in step (b), said corrected result accounting for concentration dilution due to the change in ventricular size. The method is particularly suited for the measurement of all biomarkers found in the CSF, such as those associated with mild cognitive impairment (MCI) and Alzheimer's Disease.
    Type: Application
    Filed: February 21, 2012
    Publication date: July 26, 2012
    Inventors: Mony De Leon, Henry Rusinek
  • Patent number: 8128907
    Abstract: A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anatomical protocols, determining a measurement of biomarker levels in CSF that has been extracted, correcting the measurement of the level of said at least one biomarker'according to the ventricular size, and providing a corrected result of the measurement determined in step (b), said corrected result accounting for concentration dilution due to the change in ventricular size. The method is particularly suited for the measurement of all biomarkers found in the CSF, such as those associated with mild cognitive impairment (MCI) and Alzheimer's Disease.
    Type: Grant
    Filed: April 26, 2010
    Date of Patent: March 6, 2012
    Assignee: New York University
    Inventors: Mony De Leon, Henry Rusinek
  • Publication number: 20100228115
    Abstract: A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans quantitative anatomical protocols, determining a measurement of biomarker levels in CSF that has been extracted, correcting the measurement of the level of said at least one biomarker'according to the ventricular size, and providing a corrected result of the measurement determined in step (b), said corrected result accounting for concentration dilution due to the change in ventricular size. The method is particularly suited for the measurement of all biomarkers found in the CSF, such as those associated with mild cognitive impairment (MCI) and Alzheimer's Disease.
    Type: Application
    Filed: April 26, 2010
    Publication date: September 9, 2010
    Inventors: Mony De Leon, Henry Rusinck
  • Patent number: 7736623
    Abstract: A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anatomical protocols, determining a measurement of biomarker levels in CSF that has been extracted, correcting the measurement of the level of said at least one biomarker according to the ventricular size, and providing a corrected result of the measurement determined in step (b), said corrected result accounting for concentration dilution due to the change in ventricular size. The method is particularly suited for the measurement of all biomarkers found in the CSF, such as those associated with mild cognitive impairment (MCI) and Alzheimer's Disease.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: June 15, 2010
    Assignee: New York University Medical Center
    Inventors: Mony De Leon, Henry Rusinek
  • Publication number: 20060025673
    Abstract: A method, system and storage arrangement are provided for effectuating an evaluation and analysis of anatomical structures, and creating and/or modifying images associated therewith. In particular, at least two images associated with the anatomical structure can be normalized so as to produce normalized image. A normalized set of regions of interest can be obtained based on the normalized images. Each of the normalized set of regions of interest may be analyzed to provide analysis data. Further, the anatomical structure mask may be created and/or modified based on the analysis data. Another embodiment provides for rating and analyzing anatomical structures.
    Type: Application
    Filed: July 18, 2005
    Publication date: February 2, 2006
    Inventors: Mony De Leon, Lisa Mosconi, Wai-Hon Tsui, Henry Rusinek
  • Publication number: 20050256397
    Abstract: A method is disclosed for providing a correcting factor for the dilution of measurements of at least one biomarker in cerebrospinal fluid (CSF). The method comprises providing semi-automated measurements of the ventricular system by MRI scans using quantitative anatomical protocols, determining a measurement of biomarker levels in CSF that has been extracted, correcting the measurement of the level of said at least one biomarker according to the ventricular size, and providing a corrected result of the measurement determined in step (b), said corrected result accounting for concentration dilution due to the change in ventricular size. The method is particularly suited for the measurement of all biomarkers found in the CSF, such as those associated with mild cognitive impairment (MCI) and Alzheimer's Disease.
    Type: Application
    Filed: March 20, 2003
    Publication date: November 17, 2005
    Inventors: Mony De Leon, Henry Rusinek
  • Publication number: 20050244036
    Abstract: Methods for measuring atrophy in a brain region occupied by the hippocampus and entorhinal cortex. In one example, MRI scans and a computational formula are used to measure the medial-temporal lobe region of the brain over a time interval. This region contains the hippocampus and the entorhinal cortex, structures allied with learning and memory. Each year this region of the brain shrank in people who developed memory problems up to six years after their first MRI scan. The method is also applicable for measuring the progression rate of atrophy in the region in an instance where the onset of Alzheimer's disease has already been established.
    Type: Application
    Filed: April 19, 2005
    Publication date: November 3, 2005
    Inventors: Henry Rusinek, Mony De Leon