Patents by Inventor Moon Chul Jung

Moon Chul Jung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11938482
    Abstract: A vial cap for a sample vial includes a cylindrical cap body defining a first circular opening at a first end. The vial cap also includes a cap lid extending radially inward from a second end of the cylindrical cap body. The cap lid defines a second circular opening. The vial cap also includes a septum located within the cylindrical cap body and in contact with the cap lid. The septum spans the second circular opening defined by the cap lid portion. The vial cap also includes a number of flexible threads extending from an internal surface of the cylindrical cap body.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: March 26, 2024
    Assignee: Waters Technologies Corporation
    Inventor: Moon Chul Jung
  • Patent number: 11905548
    Abstract: An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in a fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.
    Type: Grant
    Filed: August 4, 2022
    Date of Patent: February 20, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Joomi Ahn, Moon Chul Jung, Kevin D. Wyndham
  • Patent number: 11874256
    Abstract: The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.
    Type: Grant
    Filed: September 10, 2021
    Date of Patent: January 16, 2024
    Assignee: Waters Technologies Corporation
    Inventors: Amit Patel, Moon Chul Jung, Thomas H. Walter, Matthew A. Lauber, Kevin Wyndham, Mathew DeLano, Jennifer Simeone
  • Patent number: 11747341
    Abstract: The present disclosure relates to a method of analyzing a sample comprising a hydrophobic molecule. The method includes preparing an aqueous solution comprising the sample. The method also includes placing the solution in contact with a polypropylene substrate having a deactivated surface that reduces adsorption of the hydrophobic molecule relative to a polypropylene substrate that has not been deactivated. The method also includes analyzing the sample.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: September 5, 2023
    Assignee: Waters Technologies Corporation
    Inventors: Moon Chul Jung, Mary Elizabeth Lame, Caitlin Dunning, Christopher John Hughes, Xiaoxiao Liu, Paula Orens, Yun Wang Alelyunas, Erin E. Chambers, David Dao, Robert Birdsall
  • Publication number: 20230250111
    Abstract: Provided is a compound having Formula I where rings A and B are independently a five-membered or six-membered, carbocyclic or heterocyclic ring, each of which is optionally aromatic; together with nitrogen atoms bonded to ring A and ring B, ring W is a 5-membered N-heterocyclic carbene; and the remaining variables are as defined herein.
    Type: Application
    Filed: March 31, 2023
    Publication date: August 10, 2023
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Mark E. THOMPSON, Peter I. DJUROVICH, Rasha HAMZE, Shuyang SHI, Moon Chul JUNG
  • Publication number: 20230133787
    Abstract: A compound having a surface region of highly negative electrostatic potential, which comprises a ligand LA represented by Formula I may be used in organic electroluminescent devices (OLEDs) and consumer products. Transition metal complexes comprising the ligand LA of Formula I may promote molecular alignment of dopants in OLEDs.
    Type: Application
    Filed: June 2, 2022
    Publication date: May 4, 2023
    Inventors: Moon Chul JUNG, John W. FACENDOLA, Jongchan KIM, Peter I. DJUROVICH, Stephen R. FORREST, Mark E. THOMPSON
  • Publication number: 20230088954
    Abstract: An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in a fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.
    Type: Application
    Filed: August 4, 2022
    Publication date: March 23, 2023
    Applicant: Waters Technologies Corporation
    Inventors: Joomi Ahn, Moon Chul Jung, Kevin D. Wyndham
  • Patent number: 11434517
    Abstract: An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: September 6, 2022
    Assignee: Waters Technologies Corporation
    Inventors: Joomi Ahn, Moon Chul Jung, Kevin D. Wyndham
  • Publication number: 20220203360
    Abstract: A vial cap for a sample vial includes a cylindrical cap body defining a first circular opening at a first end. The vial cap also includes a cap lid extending radially inward from a second end of the cylindrical cap body. The cap lid defines a second circular opening. The vial cap also includes a septum located within the cylindrical cap body and in contact with the cap lid. The septum spans the second circular opening defined by the cap lid portion. The vial cap also includes a number of flexible threads extending from an internal surface of the cylindrical cap body.
    Type: Application
    Filed: June 1, 2021
    Publication date: June 30, 2022
    Applicant: Waters Technologies Corporation
    Inventor: Moon Chul Jung
  • Publication number: 20220091079
    Abstract: The present disclosure is directed to a kit for evaluating system inertness. The kit includes a positive control comprising a metal interacting moiety, and a negative control that does not contain a metal interacting moiety. In some embodiments the kit also includes a container to hold a system suitability solution (e.g., an equimolar mixture of the positive control and the negative control).
    Type: Application
    Filed: September 10, 2021
    Publication date: March 24, 2022
    Applicant: Waters Technologies Corporation
    Inventors: Amit Patel, Moon Chul Jung, Susan Rzewuski, Matthew A. Lauber, Thomas H. Walter, Kevin Wyndham, Mathew DeLano, Jennifer Simeone
  • Publication number: 20220082532
    Abstract: The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.
    Type: Application
    Filed: September 10, 2021
    Publication date: March 17, 2022
    Applicant: Waters Technologies Corporation
    Inventors: Amit Patel, Moon Chul Jung, Susan Rzewuski, Thomas H. Walter, Matthew A. Lauber, Kevin Wyndham, Mathew DeLano, Jennifer Simeone
  • Publication number: 20220082531
    Abstract: The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a chromatographic column, wherein the positive control is a sensitive probe that interacts with the system and the negative control is substantially non-interacting with the system; after passing the sample through the chromatographic column, detecting the positive control and the negative control; and determining system suitability by comparing the amount of detected positive control to negative control. In some embodiments, determining system suitability (e.g., inertness of sample to the system) is accomplished by determining a ratio of detected positive control to negative control.
    Type: Application
    Filed: September 10, 2021
    Publication date: March 17, 2022
    Applicant: Waters Technologies Corporation
    Inventors: Amit Patel, Moon Chul Jung, Susan Rzewuski, Thomas H. Walter, Matthew A. Lauber, Kevin Wyndham, Mathew DeLano, Jennifer Simeone
  • Patent number: 11161065
    Abstract: A liquid chromatography system, includes a fluidic flow path, a chromatography column located in the fluidic flow path, a filtration device located in the fluidic flow path before the chromatography column, the filtration device including a housing having a fluidic inlet, a fluidic outlet, wherein at least a portion of the fluidic flow path is located between the fluidic inlet and the fluidic outlet and at least one filter disposed in the portion of the fluidic flow path, wherein the at least one filter is made of a micromachined material. Liquid chromatography filtration methods are further disclosed.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: November 2, 2021
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Kevin D. Wyndham, Moon Chul Jung, Abhijit Tarafder, Wade P. Leveille, Sr.
  • Patent number: 11125729
    Abstract: In various aspects provided are purification media and containers for dispensing a purified liquid are provided herein where a high surface area-to-volume chemically interactive purification media positioned at the outlet of a container that purifies the liquid as it is dispensed and/or extracted.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: September 21, 2021
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Moon Chul Jung, Abhijit Tarafder, Wade P. Leveille
  • Patent number: 11085905
    Abstract: Various embodiments are generally directed to techniques for monitoring chromatographic fluid flows, such as the flow to and/or from one or more reservoirs used in chromatographic operations, for instance. In many embodiments, the chromatographic operations may include one or more of High Performance Liquid Chromatography (HPLC), Ultra Performance Liquid Chromatography (UPLC), Ultra Performance Convergence Chromatography (UPC2), and the like. Several embodiments are particularly directed to a chromatographic fluid flow device (CFFD) for monitoring a change in density of a chromatographic fluid in a tube, such as by detecting the presence or absence of gas in the tube with an ultrasonic bubble detector. In various embodiments, the chromatographic fluid may include a solvent, a sample, or waste associated with a chromatographic operation.
    Type: Grant
    Filed: June 12, 2019
    Date of Patent: August 10, 2021
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Abhijit Tarafder, Jonathan Belanger, Moon Chul Jung, Wade P. Leveille
  • Patent number: 11041834
    Abstract: A chromatographic device includes a primary channel having a cross-sectional area and characteristic length such that analyte travel within the primary channel is substantially convective. A plurality of secondary channels each having a cross-sectional area and characteristic length such that analyte flow into and out of a secondary channel is substantially diffusive, each of the plurality of secondary channels having an entrance in fluidic communication with the primary channel wherein the entrance intersects the primary channel.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: June 22, 2021
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Abhijit Tarafder, Moon Chul Jung, Edouard S. P. Bouvier
  • Patent number: 10953346
    Abstract: Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: March 23, 2021
    Assignee: Waters Technologies Corporation
    Inventors: Xiangjin Song, James P. Murphy, Keith Fadgen, Wade P. Leveille, Joseph D. Michienzi, Jonathan L. Belanger, Moon Chul Jung, Abhijit Tarafder
  • Patent number: 10823713
    Abstract: The present disclosure generally relates to systems, methods and devices for providing pressurized solvent flow in chromatography systems.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: November 3, 2020
    Assignee: Waters Technologies Corporation
    Inventors: Wade P. Leveille, Jonathan L. Belanger, Moon Chul Jung, Abhijit Tarafder, Joseph Michienzi, Keith Fadgen, Kevin Wyndham, Xiangjin Song
  • Publication number: 20200284802
    Abstract: The present disclosure relates to a method of analyzing a sample comprising a hydrophobic molecule. The method includes preparing an aqueous solution comprising the sample. The method also includes placing the solution in contact with a polypropylene substrate having a deactivated surface that reduces adsorption of the hydrophobic molecule relative to a polypropylene substrate that has not been deactivated. The method also includes analyzing the sample.
    Type: Application
    Filed: March 3, 2020
    Publication date: September 10, 2020
    Applicant: Waters Technologies Corporation
    Inventors: Moon Chul Jung, Mary Elizabeth Lame, Caitlin Dunning, Christopher John Hughes, Xiaoxiao Liu, Paula Orens, Yun Wang Alelyunas, Erin E. Chambers, David Dao, Robert Birdsall
  • Patent number: 10753916
    Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. The leak detection system includes a sealable compartment disposed to surround at least one component of a chromatography system. The detector is in communication, e.g., fluid communication, with an interior of the sealable compartment and configured to detect the leak by various mean including the presence of liquid or the presence of vapor, or both within the sealable compartment.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: August 25, 2020
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Moon Chul Jung, Jonathan L. Belanger, Xiangjin Song, Abhijit Tarafder, Joseph A. Jarrell, Wade P. Leveille