Patents by Inventor Mora C. Melican

Mora C. Melican has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8366787
    Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a three-dimensional synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the three-dimensional synthetic portion comprises a foam or a three-dimensional mesh, textile, or felt.
    Type: Grant
    Filed: June 14, 2002
    Date of Patent: February 5, 2013
    Assignee: DePuy Products, Inc.
    Inventors: Laura Jean Brown, Iksoo Chun, Sridevi Dhanaraj, Prasanna Malaviya, Mora C. Melican, Alireza Rezania, Li Zhang
  • Patent number: 7914808
    Abstract: Methods of making a hybrid biologic/synthetic scaffold for repairing damaged or diseased tissue are provided. The methods include the step of suspending pieces of an extracellular matrix material in a liquid to form a slurry, and coating a synthetic mat with the slurry, or mixing or layering the slurry with a synthetic polymer solution. The liquid is subsequently driven off so as to form a foam. Porous implantable scaffolds fabricated by such a method are also disclosed.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: March 29, 2011
    Assignee: DePuy Products, Inc.
    Inventors: Prasanna Malaviya, Mora C. Melican, Alireza Rezania, Iksoo Chun
  • Patent number: 7674408
    Abstract: The present invention provides a biomedical, biocompatible, polymeric foam scaffold suitable for use in the repair and regeneration of tissue and which contains located therein a network of, branched channels that are effective to encourage and facilitate vascularization and tissue growth within the scaffold and to methods for making such biomedical scaffolds.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: March 9, 2010
    Assignee: Ethicon, Inc.
    Inventors: Kelly R. Brown, Mora C. Melican, Iksoo Chun
  • Patent number: 7192604
    Abstract: An implantable biodegradable device is disclosed containing a fibrous matrix, the fibrous matrix being constructed from fibers A and fibers B, wherein fibers A biodegrade faster than fibers B, fibers A and fibers B are present in relative amounts and are organized such that the fibrous matrix is provided with properties useful in repair and/or regeneration of mammalian tissue.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: March 20, 2007
    Assignee: Ethicon, Inc.
    Inventors: Kelly R. Brown, Iksoo Chun, Joseph J. Hammer, Victor F. Janas, Jennifer Mandanas, Mora C Melican, Alireza Rezania, Mark C. Zimmerman
  • Patent number: 7160333
    Abstract: Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: January 9, 2007
    Assignee: DePuy Orthopaedics, Inc.
    Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
  • Patent number: 7112417
    Abstract: The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: September 26, 2006
    Assignee: Ethicon, Inc.
    Inventors: Murty N. Vyakarnam, Mark C. Zimmerman, Angelo George Scopelianos, Iksoo Chun, Mora C. Melican, Clairene A. Bazilio, Mark B. Roller, David V. Gorky
  • Patent number: 7005136
    Abstract: The present invention is directed to bone replacement devices and compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: February 28, 2006
    Assignee: Ethicon, Inc.
    Inventors: Aruna Nathan, Mora C. Melican, Kelly R. Brown, Mark C. Zimmerman
  • Patent number: 6787179
    Abstract: The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: September 7, 2004
    Assignee: Ethicon, Inc.
    Inventors: Debra A. Timm, Henry K. Hui, Mark B. Roller, Mora C. Melican, Syed Hossainy
  • Publication number: 20040059431
    Abstract: Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 25, 2004
    Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
  • Patent number: 6638312
    Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the synthetic portion comprises one or more rows of fibers or mesh positioned between layers of the small intestine submucosa.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: October 28, 2003
    Assignee: DePuy Orthopaedics, Inc.
    Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
  • Publication number: 20030185871
    Abstract: The present invention is directed to bone replacement devices and compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.
    Type: Application
    Filed: March 29, 2002
    Publication date: October 2, 2003
    Inventors: Aruna Nathan, Mora C. Melican, Kelly R. Brown, Mark C. Zimmerman
  • Publication number: 20030181978
    Abstract: The present invention provides a biomedical, biocompatible, polymeric foam scaffold suitable for use in the repair and regeneration of tissue and which contains located therein a network of, branched channels that are effective to encourage and facilitate vascularization and tissue growth within the scaffold and to methods for making such biomedical scaffolds.
    Type: Application
    Filed: March 25, 2002
    Publication date: September 25, 2003
    Inventors: Kelly R. Brown, Mora C. Melican, Iksoo Chun
  • Publication number: 20030175408
    Abstract: The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.
    Type: Application
    Filed: June 29, 2001
    Publication date: September 18, 2003
    Inventors: Debra A. Timm, Henry K. Hui, Mark B. Roller, Mora C. Melican, Syed Hossainy
  • Publication number: 20030077311
    Abstract: The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
    Type: Application
    Filed: August 24, 2001
    Publication date: April 24, 2003
    Inventors: Murty N. Vyakarnam, Mark C. Zimmerman, Angelo George Scopelianos, Iksoo Chun, Mora C. Melican, Clairene A. Bazilio, Mark B. Roller, David V. Gorky
  • Publication number: 20030023316
    Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a three-dimensional synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the three-dimensional synthetic portion comprises a foam or a three-dimensional mesh, textile, or felt.
    Type: Application
    Filed: June 14, 2002
    Publication date: January 30, 2003
    Inventors: Laura Jean Brown, Iksoo Chun, Sridevi Dhanaraj, Prasanna Malaviya, Mora C. Melican, Alireza Rezania, Li Zhang
  • Publication number: 20030021827
    Abstract: Methods of making a hybrid biologic/synthetic scaffold for repairing damaged or diseased tissue are provided. The methods include the step of suspending pieces of an extracellular matrix material in a liquid to form a slurry, and coating a synthetic mat with the slurry, or mixing or layering the slurry with a synthetic polymer solution. The liquid is subsequently driven off so as to form a foam. Porous implantable scaffolds fabricated by such a method are also disclosed.
    Type: Application
    Filed: July 15, 2002
    Publication date: January 30, 2003
    Inventors: Prasanna Malaviya, Mora C. Melican, Alireza Rezania, Iksoo Chun
  • Publication number: 20020131989
    Abstract: An implantable biodegradable device is disclosed containing a fibrous matrix, the fibrous matrix being constructed from fibers A and fibers B, wherein fibers A biodegrade faster than fibers B, fibers A and fibers B are present in relative amounts and are organized such that the fibrous matrix is provided with properties useful in repair and/or regeneration of mammalian tissue.
    Type: Application
    Filed: December 7, 2001
    Publication date: September 19, 2002
    Inventors: Kelly R. Brown, Iksoo Chun, Joseph J. Hammer, Victor F. Janas, Jennifer Mandanas, Mora C. Melican, Alireza Rezania, Mark C. Zimmerman
  • Patent number: 6423252
    Abstract: The present invention is directed to a method of making a foam, the method including contacting a polymer solution with a surface of a mold, the solution containing dissolved therein a biocompatible polymer, the mold containing disposed on at least one surface thereof a three-dimensional negative configuration of a predetermined micropattern to be disposed on and integral with at least one surface of the foam, lyophilizing the solution while in contact with the surface of the mold and removing the lyophilized micropatterned foam from the mold.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: July 23, 2002
    Assignee: Ethicon, Inc.
    Inventors: Iksoo Chun, Yufu Li, Mora C. Melican
  • Publication number: 20020038151
    Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the synthetic portion comprises one or more rows of fibers or mesh positioned between layers of the small intestine submucosa.
    Type: Application
    Filed: July 30, 2001
    Publication date: March 28, 2002
    Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
  • Patent number: 6306424
    Abstract: The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: October 23, 2001
    Assignee: Ethicon, Inc.
    Inventors: Murty N. Vyakarnam, Mark C. Zimmerman, Angelo George Scopelianos, Iksoo Chun, Mora C. Melican, Clairene A. Bazilio, Mark B. Roller, David V. Gorky