Patents by Inventor Mora C. Melican
Mora C. Melican has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8366787Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a three-dimensional synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the three-dimensional synthetic portion comprises a foam or a three-dimensional mesh, textile, or felt.Type: GrantFiled: June 14, 2002Date of Patent: February 5, 2013Assignee: DePuy Products, Inc.Inventors: Laura Jean Brown, Iksoo Chun, Sridevi Dhanaraj, Prasanna Malaviya, Mora C. Melican, Alireza Rezania, Li Zhang
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Patent number: 7914808Abstract: Methods of making a hybrid biologic/synthetic scaffold for repairing damaged or diseased tissue are provided. The methods include the step of suspending pieces of an extracellular matrix material in a liquid to form a slurry, and coating a synthetic mat with the slurry, or mixing or layering the slurry with a synthetic polymer solution. The liquid is subsequently driven off so as to form a foam. Porous implantable scaffolds fabricated by such a method are also disclosed.Type: GrantFiled: July 15, 2002Date of Patent: March 29, 2011Assignee: DePuy Products, Inc.Inventors: Prasanna Malaviya, Mora C. Melican, Alireza Rezania, Iksoo Chun
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Patent number: 7674408Abstract: The present invention provides a biomedical, biocompatible, polymeric foam scaffold suitable for use in the repair and regeneration of tissue and which contains located therein a network of, branched channels that are effective to encourage and facilitate vascularization and tissue growth within the scaffold and to methods for making such biomedical scaffolds.Type: GrantFiled: September 19, 2005Date of Patent: March 9, 2010Assignee: Ethicon, Inc.Inventors: Kelly R. Brown, Mora C. Melican, Iksoo Chun
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Patent number: 7192604Abstract: An implantable biodegradable device is disclosed containing a fibrous matrix, the fibrous matrix being constructed from fibers A and fibers B, wherein fibers A biodegrade faster than fibers B, fibers A and fibers B are present in relative amounts and are organized such that the fibrous matrix is provided with properties useful in repair and/or regeneration of mammalian tissue.Type: GrantFiled: December 7, 2001Date of Patent: March 20, 2007Assignee: Ethicon, Inc.Inventors: Kelly R. Brown, Iksoo Chun, Joseph J. Hammer, Victor F. Janas, Jennifer Mandanas, Mora C Melican, Alireza Rezania, Mark C. Zimmerman
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Patent number: 7160333Abstract: Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion.Type: GrantFiled: September 5, 2003Date of Patent: January 9, 2007Assignee: DePuy Orthopaedics, Inc.Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
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Patent number: 7112417Abstract: The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.Type: GrantFiled: August 24, 2001Date of Patent: September 26, 2006Assignee: Ethicon, Inc.Inventors: Murty N. Vyakarnam, Mark C. Zimmerman, Angelo George Scopelianos, Iksoo Chun, Mora C. Melican, Clairene A. Bazilio, Mark B. Roller, David V. Gorky
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Patent number: 7005136Abstract: The present invention is directed to bone replacement devices and compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.Type: GrantFiled: March 29, 2002Date of Patent: February 28, 2006Assignee: Ethicon, Inc.Inventors: Aruna Nathan, Mora C. Melican, Kelly R. Brown, Mark C. Zimmerman
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Patent number: 6787179Abstract: The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.Type: GrantFiled: June 29, 2001Date of Patent: September 7, 2004Assignee: Ethicon, Inc.Inventors: Debra A. Timm, Henry K. Hui, Mark B. Roller, Mora C. Melican, Syed Hossainy
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Publication number: 20040059431Abstract: Bioprosthetic devices for soft tissue attachment, reinforcement, or construction are provided. The devices comprise a sheet of naturally occurring extracellular matrix and a sheet of synthetic mesh coupled to the naturally occurring extracellular matrix portion.Type: ApplicationFiled: September 5, 2003Publication date: March 25, 2004Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
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Patent number: 6638312Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the synthetic portion comprises one or more rows of fibers or mesh positioned between layers of the small intestine submucosa.Type: GrantFiled: July 30, 2001Date of Patent: October 28, 2003Assignee: DePuy Orthopaedics, Inc.Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
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Publication number: 20030185871Abstract: The present invention is directed to bone replacement devices and compositions containing a synthetic, bioabsorbable, biocompatible liquid polymer that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the liquid polymer having a melting point less than about 40° C., as determined by differential scanning calorimetry.Type: ApplicationFiled: March 29, 2002Publication date: October 2, 2003Inventors: Aruna Nathan, Mora C. Melican, Kelly R. Brown, Mark C. Zimmerman
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Publication number: 20030181978Abstract: The present invention provides a biomedical, biocompatible, polymeric foam scaffold suitable for use in the repair and regeneration of tissue and which contains located therein a network of, branched channels that are effective to encourage and facilitate vascularization and tissue growth within the scaffold and to methods for making such biomedical scaffolds.Type: ApplicationFiled: March 25, 2002Publication date: September 25, 2003Inventors: Kelly R. Brown, Mora C. Melican, Iksoo Chun
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Publication number: 20030175408Abstract: The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.Type: ApplicationFiled: June 29, 2001Publication date: September 18, 2003Inventors: Debra A. Timm, Henry K. Hui, Mark B. Roller, Mora C. Melican, Syed Hossainy
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Publication number: 20030077311Abstract: The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.Type: ApplicationFiled: August 24, 2001Publication date: April 24, 2003Inventors: Murty N. Vyakarnam, Mark C. Zimmerman, Angelo George Scopelianos, Iksoo Chun, Mora C. Melican, Clairene A. Bazilio, Mark B. Roller, David V. Gorky
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Publication number: 20030021827Abstract: Methods of making a hybrid biologic/synthetic scaffold for repairing damaged or diseased tissue are provided. The methods include the step of suspending pieces of an extracellular matrix material in a liquid to form a slurry, and coating a synthetic mat with the slurry, or mixing or layering the slurry with a synthetic polymer solution. The liquid is subsequently driven off so as to form a foam. Porous implantable scaffolds fabricated by such a method are also disclosed.Type: ApplicationFiled: July 15, 2002Publication date: January 30, 2003Inventors: Prasanna Malaviya, Mora C. Melican, Alireza Rezania, Iksoo Chun
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Publication number: 20030023316Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a three-dimensional synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the three-dimensional synthetic portion comprises a foam or a three-dimensional mesh, textile, or felt.Type: ApplicationFiled: June 14, 2002Publication date: January 30, 2003Inventors: Laura Jean Brown, Iksoo Chun, Sridevi Dhanaraj, Prasanna Malaviya, Mora C. Melican, Alireza Rezania, Li Zhang
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Publication number: 20020131989Abstract: An implantable biodegradable device is disclosed containing a fibrous matrix, the fibrous matrix being constructed from fibers A and fibers B, wherein fibers A biodegrade faster than fibers B, fibers A and fibers B are present in relative amounts and are organized such that the fibrous matrix is provided with properties useful in repair and/or regeneration of mammalian tissue.Type: ApplicationFiled: December 7, 2001Publication date: September 19, 2002Inventors: Kelly R. Brown, Iksoo Chun, Joseph J. Hammer, Victor F. Janas, Jennifer Mandanas, Mora C. Melican, Alireza Rezania, Mark C. Zimmerman
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Patent number: 6423252Abstract: The present invention is directed to a method of making a foam, the method including contacting a polymer solution with a surface of a mold, the solution containing dissolved therein a biocompatible polymer, the mold containing disposed on at least one surface thereof a three-dimensional negative configuration of a predetermined micropattern to be disposed on and integral with at least one surface of the foam, lyophilizing the solution while in contact with the surface of the mold and removing the lyophilized micropatterned foam from the mold.Type: GrantFiled: June 23, 2000Date of Patent: July 23, 2002Assignee: Ethicon, Inc.Inventors: Iksoo Chun, Yufu Li, Mora C. Melican
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Publication number: 20020038151Abstract: A bioprosthetic device is provided for soft tissue attachment, reinforcement, and or reconstruction. The device comprises a naturally occurring extracellular matrix portion and a synthetic portion. In illustrated embodiments, the naturally occurring extracellular matrix portion comprises layers of small intestine submucosa, and the synthetic portion comprises one or more rows of fibers or mesh positioned between layers of the small intestine submucosa.Type: ApplicationFiled: July 30, 2001Publication date: March 28, 2002Inventors: Pamela L. Plouhar, Prasanna Malaviya, Joe W. Ferguson, Mora C. Melican
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Patent number: 6306424Abstract: The present patent describes a biocompatible composite made of a first fibrous layer attached to a three-dimensional inter-connected open cell porous foams that have a gradient in composition and/or microstructure through one or more directions. These composites can be made from blends of absorbable and biocompatible polymers. These biocompatible composites are particularly well suited to tissue engineering applications and can be designed to mimic tissue transition or interface zones.Type: GrantFiled: December 21, 1999Date of Patent: October 23, 2001Assignee: Ethicon, Inc.Inventors: Murty N. Vyakarnam, Mark C. Zimmerman, Angelo George Scopelianos, Iksoo Chun, Mora C. Melican, Clairene A. Bazilio, Mark B. Roller, David V. Gorky