Patents by Inventor Morayma TEMOCHE-DIAZ

Morayma TEMOCHE-DIAZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20250059568
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: August 27, 2024
    Publication date: February 20, 2025
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • ENGINEERED AND CHIMERIC NUCLEASES
    Publication number: 20250002886
    Abstract: Disclosed herein are engineered nucleases and nuclease systems, including chimeric nucleases and chimeric nuclease systems. Engineered and chimeric nucleases disclosed herein include nucleic acid guided nuclease. Additionally disclosed herein are methods of generating engineered nucleases and methods of using the same.
    Type: Application
    Filed: September 13, 2024
    Publication date: January 2, 2025
    Inventors: Brian C. Thomas, Alan Brooks, Christopher Brown, Cristina Noel Butterfield, Daniela S.A. Goltsman, Jyun-Liang Lin, Isabel Nocedal, Morayma Temoche-Diaz
  • SYSTEMS AND METHODS FOR TRANSPOSING CARGO NUCLEOTIDE SEQUENCES
    Publication number: 20240360477
    Abstract: The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods may comprise a first double-stranded nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a retrotransposase, and the retrotransposase, wherein said retrotransposase is configured to transpose the cargo nucleotide sequence to the target nucleic acid site.
    Type: Application
    Filed: March 7, 2024
    Publication date: October 31, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Daniela S.A. GOLTSMAN, Sarah LAPERRIERE, Cindy CASTELLE, Lisa ALEXANDER, Mary Kaitlyn Chiu, Morayma TEMOCHE-DIAZ, Anu THOMAS
  • ENZYMES WITH HEPN DOMAINS
    Publication number: 20240352433
    Abstract: The present disclosure provides for endonuclease enzymes having HEPN domains, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: April 25, 2024
    Publication date: October 24, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Cindy CASTELLE, Lisa ALEXANDER, Liliana GONZALEZ-OSORIO, Morayma TEMOCHE-DIAZ
  • Class II, type V CRISPR systems
    Patent number: 12123014
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Grant
    Filed: April 18, 2023
    Date of Patent: October 22, 2024
    Assignee: Metagenomi, Inc.
    Inventors: Brian Thomas, Christopher Brown, Audra Devoto, Cristina Butterfield, Lisa Alexander, Daniela S. A. Goltsman, Justine Albers, Alan Brooks, Greg Cost, Morayma Temoche-Diaz, Cindy Castelle, Rebecca Lamothe
  • BASE EDITING ENZYMES
    Publication number: 20240309404
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: May 2, 2024
    Publication date: September 19, 2024
    Inventors: Brian C. THOMAS, Jyun-Liang LIN, Alan BROOKS, Cristina BUTTERFIELD, Christopher BROWN, Cindy CASTELLE, Morayma TEMOCHE-DIAZ, Benjamin FREEMAN, Christine ROMANO, Rebecca LAMOTHE
  • SYSTEMS, COMPOSITIONS, AND METHODS INVOLVING RETROTRANSPOSONS AND FUNCTIONAL FRAGMENTS THEREOF
    Publication number: 20240287484
    Abstract: The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods can comprise a nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a retrotransposase, and the retrotransposase, wherein said retrotransposase is configured to transpose the cargo nucleotide sequence to the target nucleic acid site. The systems and methods can also involve use of functional fragments of retrotransposases.
    Type: Application
    Filed: March 7, 2024
    Publication date: August 29, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Daniela S.A. GOLTSMAN, Sarah LAPERRIERE, Cindy CASTELLE, Lisa ALEXANDER, Mary Kaitlyn Chiu, Morayma TEMOCHE-DIAZ, Anu THOMAS
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20240093239
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: April 18, 2023
    Publication date: March 21, 2024
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • Class II, type V CRISPR systems
    Patent number: 11713471
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: August 1, 2023
    Assignee: METAGENOMI, INC.
    Inventors: Brian Thomas, Christopher Brown, Audra Devoto, Cristina Butterfield, Lisa Alexander, Daniela S. A. Goltsman, Justine Albers, Alan Brooks, Greg Cost, Morayma Temoche-Diaz, Cindy Castelle, Rebecca Lamothe
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20230227857
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: September 6, 2022
    Publication date: July 20, 2023
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine B. ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • CLASS II, TYPE V CRISPR SYSTEMS
    Publication number: 20220290187
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: March 28, 2022
    Publication date: September 15, 2022
    Inventors: Brian C. THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine B. ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE