Patents by Inventor Moreno Zamai

Moreno Zamai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polymeric conjugates of antitumor agents
    Publication number: 20030195152
    Abstract: Water soluble polymeric conjugates of antitumor agents of formula (A) P-[W2]p-S0-[W1]r-[D] wherein: P is a water soluble polymer; [W1] is a residue of formula —HN-Z1-CO— in which Z1 represents a linear or branched C2-C12 alkylene chain or the residue of formula —C6HC—CH2—O—; [W2] is a residue of formula —HN-Z2-CO— in which Z2 represents a C2-C12 linear or branched alkylene chain; p and r are 0 or 1; S0 is a peptide that selectively is cleaved at the tumor site mainly by the action of the matrix metalloproteinases gelatinase; [D] is the residue of an antitumor agent. The conjugates possess enhanced antitumor activity and decreased toxicity with respect to the free drug. A process for their preparation, useful intermediates and pharmaceutical compositions containing them are also described.
    Type: Application
    Filed: April 10, 2003
    Publication date: October 16, 2003
    Inventors: Antonio Suarato, Francesco Angelucci, Michele Caruso, Alessandro Scolaro, Daniele Volpi, Moreno Zamai
  • Polymeric derivatives of camptothecins
    Patent number: 6328953
    Abstract: The invention relates to polymeric conjugates of 20-O-[glycyl-aminoacyl-glycyl]-camptothecins and a process for producing the same.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: December 11, 2001
    Assignee: Pharmacia & Upjohn S.p.A.
    Inventors: Francesco Angelucci, Fabrizio Orzi, Gabriele Fachin, Valeria Caiolfa, Moreno Zamai, Antonino Suarato