Abstract: The disclosure provides various embodiments of systems to facilitate the cutting of tissue structures and other tissue structures percutaneously.

Abstract: The disclosure provides various embodiments of catheters having articulable ends that can be used for various procedures. Embodiments of methods are also provided that can be performed with catheters in accordance with the present disclosure.

Abstract: The disclosure provides various embodiments of systems to facilitate the cutting of tissue structures and other tissue structures percutaneously.

Abstract: The disclosure provides various embodiments of systems to facilitate the cutting of tissue structures and other tissue structures percutaneously.

Abstract: Apparatus, for use at a valve of a heart of a subject, includes a first catheter, a second catheter, and a translation element. The translation element is connected to, and operatively joins, the distal ends of the first catheter and the second catheter. The translation element is operable to translate the distal ends laterally with respect to each other to transition the apparatus between (i) a first state in which the distal ends are held next to each other for transluminal advancement to the heart, and (ii) a second state in which the distal ends are spaced apart from each other for positioning at a first location on the annulus and a second location on the annulus, respectively. The apparatus is configured to, while in the second state, from the distal ends, anchor a first tissue anchor at the first location, and a second tissue anchor at the second location.

Abstract: A catheter assembly comprises a catheter, a handle, disposed at a proximal part of the catheter, a pull wire, extending from a distal part of the catheter, proximally through the catheter to the handle, and a control handle assembly, disposed at the handle, and configured to be operated: (i) in a gross-tensioning manner that grossly adjusts tension on the pull wire, and (ii) in a fine-tensioning manner that finely adjusts the tension on the pull wire. Other embodiments are also described.

Abstract: The disclosure provides various embodiments of catheters that can be used for various procedures. Embodiments of methods are also provided that can be performed with catheters in accordance with the present disclosure.

Abstract: A catheter system including a wire, a translatable catheter, and first and second tethers is introduced into a body of a subject. The translatable catheter has a curved portion proximate a distal end of the translatable catheter. The first tether is coupled to the wire, and passes proximally through the translatable catheter. The second tether is attached to the curved portion. The catheter system is positioned such that the wire is disposed at a first location in the body. While the wire remains at the first location, the translatable catheter is translated away from the wire by manipulating the first tether and the second tether. Other embodiments are also described.

Abstract: A handle shaft is disposed at a proximal end of a catheter. A wire extends from a distal part of the catheter, proximally through the catheter to the handle shaft. A knob is disposed outside of the handle shaft. A threaded mechanism provides operative coupling between the knob and the handle shaft such that (i) rotation of the knob with respect to the handle shaft alters tension in the wire via the threaded mechanism functioning as a linear actuator; and (ii) non-rotational axial movement of the knob with respect to the handle shaft alters tension in the wire without the threaded mechanism functioning as a linear actuator. Other embodiments are also described.

Abstract: The present teachings provide systems, devices, and methods for treating the heart and reducing valve regurgitation. A delivery catheter is used to advance a balloon to a treatment site outside the heart. The balloon includes a flexible outer layer encasing a primary cavity and a secondary cavity outside of the primary cavity. The secondary cavity contains a tissue-binding adhesive. While the balloon is at the treatment site, an injection medium is introduced into the primary cavity in a manner that inflates the balloon from a collapsed delivery profile into an inflated deployment profile, and squeezes the tissue-binding adhesive out of the secondary cavity. Other embodiments are also described.

Abstract: The present disclosure provides embodiments of devices that are useful in the structural remodeling of various parts of the cardiovascular system, most notably the heart. Certain of the disclosed devices relate to RAMIN procedures (“remodeling and ablation using myocardial interstitial navigation”). RAMIN procedures, as described herein, represent a new family of non-surgical catheter-based procedures in order to accomplish ablation, drug delivery, re-shaping, pacing, and related structural heart interventional procedures, as desired.

Abstract: The present teachings provide systems, devices, and methods for reshaping the heart and reducing valve regurgitation. A device can be positioned proximate the heart and have a delivery profile and an inflated profile. The device can have a primary cavity and a secondary cavity, and an adhesive inside the secondary cavity. An injectable medium can be injected to the primary cavity of the device. As the primary cavity is filled, the adhesive is forced out of the secondary cavity to adhere the device. The inflated device can exert pressure on the heart, change the shape of a valve annulus, and allow a better coaptation of the valve leaflets.

Abstract: The disclosure provides various embodiments of systems to facilitate the cutting of luminal tissue structures percutaneously.

Abstract: The disclosure provides various embodiments of systems to facilitate the cutting of luminal tissue structures percutaneously.

Abstract: The disclosure provides various embodiments of catheters having articulable ends that can be used for various procedures. Embodiments of methods are also provided that can be performed with catheters in accordance with the present disclosure.

Abstract: The disclosure provides various embodiments of catheters having articulable ends that can be used for various procedures. Embodiments of methods are also provided that can be performed with catheters in accordance with the present disclosure.

Abstract: The disclosure provides various embodiments of systems to facilitate the cutting of luminal tissue structures percutaneously.

Abstract: A handle shaft is disposed at a proximal end of a catheter. A wire extends from a distal part of the catheter, proximally through the catheter to the handle shaft. A knob is disposed outside of the handle shaft. A threaded mechanism provides operative coupling between the knob and the handle shaft such that (i) rotation of the knob with respect to the handle shaft alters tension in the wire via the threaded mechanism functioning as a linear actuator; and (ii) non-rotational axial movement of the knob with respect to the handle shaft alters tension in the wire without the threaded mechanism functioning as a linear actuator. Other embodiments are also described.

Abstract: The present teachings provide a delivery catheter with a deflectable tip and the deflection angle of the deflectable tip can be accurately controlled. Specifically, the delivery catheter includes a deflectable distal tip operably coupled to a pull wire, an elongated catheter portion, and a control mechanism. The control mechanism is configured to activate a rapid transformation of the deflectable tip from its linear profile to its curved profile. The control mechanism further includes a linear actuation mechanism. Such linear actuation mechanism converts a rotation motion of the control mechanism to a precise linear motion, which in turn accurately controls the bend angle of the deflectable tip of the delivery catheter. Such control mechanism can be used in applications that require the control of the distal deflection of the catheter, such as EP catheter, trans-septal device, and other devices.

Abstract: The present disclosure provides for novel ways of delivering tensioning elements, such as tethers, and deployable anchors, to a desired location within the anatomy of a patient. More specifically, the present disclosure provides a system and method for delivering deployable anchors to a desire location within the anatomy and tethering the anchors together through tissue. The deployable anchors may include anchors that have a pre-deployment elongate configuration and a post-deployment planar configuration.