Patents by Inventor Morgan Maeder

Morgan Maeder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Increasing Specificity for RNA-Guided Genome Editing
    Publication number: 20180208921
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
    Type: Application
    Filed: January 12, 2018
    Publication date: July 26, 2018
    Inventors: J. Keith Joung, James Angstman, Jeffry D. Sander, Morgan Maeder, Shengdar Tsai
  • TAL-Tet1 Fusion Proteins and Methods of Use Thereof
    Publication number: 20180187168
    Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
    Type: Application
    Filed: February 12, 2018
    Publication date: July 5, 2018
    Inventors: J. Keith Joung, Morgan Maeder, James Angstman
  • TAL-Tet1 fusion proteins and methods of use thereof
    Patent number: 9890364
    Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 13, 2018
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Morgan Maeder, James Angstman
  • Increasing specificity for RNA-guided genome editing
    Patent number: 9885033
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 6, 2018
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, James Angstman, Jeffry D. Sander, Morgan Maeder, Shengdar Tsai
  • Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing
    Publication number: 20170152508
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
    Type: Application
    Filed: February 10, 2017
    Publication date: June 1, 2017
    Inventors: J. Keith Joung, Jeffry D. Sander, Morgan Maeder, Yanfang Fu
  • TALE TRANSCRIPTIONAL ACTIVATORS
    Publication number: 20170114347
    Abstract: Computer programs, algorithms, and methods for identifying TALE-activator binding sites, and methods for generation and use of TALE-activators that bind to said sites.
    Type: Application
    Filed: January 10, 2017
    Publication date: April 27, 2017
    Inventors: J. Keith Joung, Morgan Maeder
  • Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
    Patent number: 9567604
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 14, 2017
    Assignee: The General Hospital Corporation
    Inventors: J. Keith Joung, Jeffry D. Sander, Morgan Maeder, Yanfang Fu
  • Increasing Specificity for RNA-Guided Genome Editing
    Publication number: 20160024524
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: J. Keith Joung, James Angstman, Jeffry D. Sander, Morgan Maeder, Shengdar Tsai
  • Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing
    Publication number: 20160024523
    Abstract: CRISPR-Cas genome editing uses a guide RNA, which includes both a complementarity region, which binds the target DNA by base-pairing, and a Cas9-binding region, to direct a Cas9 nuclease to a target DNA. Further disclosed are methods for increasing specificity of RNA-guided genome editing using CRISPR/Cas9 systems by using truncated guide RNAs (tru-gRNAs).
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: J. Keith Joung, Jeffry D. Sander, Yan-fang Fu, Morgan Maeder
  • RNA-Guided Targeting of Genetic and Epigenomic Regulatory Proteins to Specific Genomic Loci
    Publication number: 20160010076
    Abstract: Methods and constructs for RNA-guided targeting of heterologous functional domains such as transcriptional activators to specific genomic loci.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 14, 2016
    Inventors: J. Keith Joung, Morgan Maeder
  • TALE TRANSCRIPTIONAL ACTIVATORS
    Publication number: 20150376626
    Abstract: Computer programs, algorithms, and methods for identifying TALE-activator binding sites, and methods for generation and use of TALE-activators that bind to said sites.
    Type: Application
    Filed: February 7, 2014
    Publication date: December 31, 2015
    Inventors: J. Keith Joung, Morgan Maeder
  • ZINC FINGER NUCLEASE FOR THE CFTR GENE AND METHODS OF USE THEREOF
    Publication number: 20150093802
    Abstract: The present invention provides new zinc finger proteins and zinc finger nuclease (ZFNs) that find particular using in repairing the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
    Type: Application
    Filed: September 30, 2014
    Publication date: April 2, 2015
    Applicants: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL
    Inventors: Paul MCCRAY, Morgan MAEDER, Jae Keith JOUNG
  • RNA-GUIDED TARGETING OF GENETIC AND EPIGENOMIC REGULATORY PROTEINS TO SPECIFIC GENOMIC LOCI
    Publication number: 20140377868
    Abstract: Methods and constructs for RNA-guided targeting of transcriptional activators to specific genomic loci.
    Type: Application
    Filed: March 14, 2014
    Publication date: December 25, 2014
    Inventors: J. Keith Joung, Morgan Maeder
  • Using Truncated Guide RNAs (tru-gRNAs) to Increase Specificity for RNA-Guided Genome Editing
    Publication number: 20140295557
    Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).
    Type: Application
    Filed: March 14, 2014
    Publication date: October 2, 2014
    Applicant: The General Hospital Corporation
    Inventors: J. Keith Joung, Jeffry D. Sander, Morgan Maeder, Yanfang Fu
  • Zinc finger nuclease for the CFTR gene and methods of use thereof
    Patent number: 8846578
    Abstract: The present invention provides new zinc finger proteins and zinc finger nuclease (ZFNs) that find particular using in repairing the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: September 30, 2014
    Assignees: The General Hospital Corporation, University of Iowa Research Foundation
    Inventors: Paul McCray, Morgan Maeder, Jae Keith Joung
  • TAL-Tet1 Fusion Proteins and Methods of Use Thereof
    Publication number: 20130323220
    Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
    Type: Application
    Filed: March 15, 2013
    Publication date: December 5, 2013
    Applicant: The General Hospital Corporation
    Inventors: J. Keith Joung, Morgan Maeder, James Angstman
  • ZINC FINGER NUCLEASE FOR THE CFTR GENE AND METHODS OF USE THEREOF
    Publication number: 20110086015
    Abstract: The present invention provides new zinc finger proteins and zinc finger nuclease (ZFNs) that find particular using in repairing the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
    Type: Application
    Filed: October 15, 2010
    Publication date: April 14, 2011
    Inventors: Paul McCray, Morgan Maeder, Jae Keith Joung