Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: A system for tracking a medical device, the system comprising a support having a channel extending therethrough, the channel being defined circumferentially by a surface, at least one encoder configured to track movement of a medical device through the channel, and one or more processors configured to receive input from the at least one encoder, receive an instruction from a user to store a zero position of the medical device relative to the channel, determine relative movement of the medical device from the zero position, and communicate the relative movement of the medical device from the zero position.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to single-use endoscopic medical devices with integrated and purpose-built functionality.

Abstract: A stent system may include a stent including a first leg having a first end fixedly attached to the distal end of a main body portion and extending distally from the distal end of the main body portion in a deployed configuration, and a second leg having a first end fixedly attached to the distal end of the main body portion and extending distally from the distal end of the main body portion in the deployed configuration. The second leg may extend proximally from the distal end of the main body portion in a delivery configuration. A stent system may include a bifurcated delivery sheath and two guidewires for delivery of two stents at the same time. A method of treating a body lumen may include delivering a contrast fluid including an anti-gas agent while implanting a stent in the body lumen.

Abstract: Exemplary embodiments of the present disclosure relate to devices, systems, and methods for tissue resection in a body lumen of a patient, and may include an elongate body having a cavity at a distal end and a tissue retractor extendable distally from the distal end of the elongate body. The tissue retractor may include an expansion mechanism. The expansion mechanism may include a plurality of arms each having a first end coupled around a distal cap and expandable radially outward from the distal cap such that an anchoring mechanism on a second end of the arms is engageable with selected tissue for resection of the body lumen. The tissue resection device may further include a tissue resecting device.

Abstract: Exemplary embodiments of the present disclosure relate to devices, systems, and methods for tissue resection in a body lumen of a patient, and may include a body extending along an axis and a distal cap positioned distally of the body and coupled to a shaft extending along the axis. The body and the distal cap may be movable relative to each other. An anchoring mechanism may be capable of engaging the body and the distal cap proximate a selected tissue for resection in the body lumen. A tissue capture device may be deployable from the tissue resection device such that a selected tissue for resection is securable by the tissue capture device. The tissue resection device may further include a tissue resecting device for resecting the selected tissue for resection.

Abstract: The present disclosure relates generally to systems, devices, and methods for endoscopic suture termination. In some embodiments, a suture device may include an elongate member having a working channel and a suture channel, the elongate member having a proximal end and a distal end. The suture device may further include a suture extending through the suture channel, and a plurality of anchor components coupled to the suture, wherein the suture and the plurality of anchor components are deployable from the elongate member for engagement with a target tissue.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to single-use endoscopic medical devices with integrated and purpose-built functionality.

Abstract: Exemplary embodiments of the present disclosure relate to devices, systems, and methods for tissue resection in a body lumen of a patient, and may include a body extending along an axis and a distal cap positioned distally of the body and coupled to a shaft extending along the axis. The body and the distal cap may be movable relative to each other. An anchoring mechanism may be capable of engaging the body and the distal cap proximate a selected tissue for resection in the body lumen. A tissue capture device may be deployable from the tissue resection device such that a selected tissue for resection is securable by the tissue capture device. The tissue resection device may further include a tissue resecting device for resecting the selected tissue for resection.