Abstract: A system and method for optimized industrial production using machine learning. The method includes creating a model defining dependencies among a plurality of parameters for an industrial production process, the plurality of parameters including a plurality of controlled parameters and a plurality of monitored parameters; training an agent via reinforcement learning based on iterative application of the model, wherein the agent is trained to determine new values for the plurality of controlled parameters based on current values of the plurality of monitored parameters in order to optimize the industrial production process with respect to at least one predetermined objective; and iteratively modifying, by the trained agent, current values of the plurality of controlled parameters in real-time during operation of the industrial production process.

Abstract: An apparatus configured to perform in-situ, real-time, noninvasive monitoring of fermentation processes at a location remote from the fermenter/bioreactor in a laboratory or an industrial environment is described. The apparatus enables monitoring and detection of CO2 in fermentation-based processes with high precision, continuously and in real time from the exhaust pipe or exhaust bypass of any size or type of fermenter/bioreactor or pipe diameter.

Abstract: Presented herein is a method for in-situ real-time non-invasive estimation of the level of living cells proliferation and/or growth in a biological material present in a container sealed to prevent biological contamination. The method comprises measuring the concentration of at least one metabolic gas that is emitted by the living cells. The method can be adapted inter alia to detect a microorganism contamination in a storage container for platelets sealed to biological contamination, to monitor a fermentation process in a fermenter enclosing microorganisms and sealed to biological contamination, and to monitor the concentration of living cells in a bioreactor sealed to biological contamination.

Abstract: A method and system for measuring metabolic gas concentration. The method includes: applying, via a tunable coherent infrared light source, an infrared light beam to a region of interest, wherein the region of interest is positioned between the tunable coherent infrared light source and a detection module, wherein the region of interest is in fluid communication with a biological material including living cells emitting a metabolic gas; measuring, via the detection module, a plurality of signals based on the application of the infrared light beam to the region of interest, wherein measuring each of the plurality of signals further comprises tuning the tunable coherent infrared light source; and determining the concentration of the metabolic gas based on the plurality of signals.

Abstract: An optical system for determining the concentration of a metabolic gas in a container sealed to biological contamination and enclosing a biological material. The optical system has a broadly tunable coherent infrared light source, a detection module, and a control system connected to the light source and detection module and operates the light source, to receive and analyze the data provided by said detection module, and to process the data indicative of the concentration of said metabolic gas in said sealed container.

Abstract: A biological material such as platelets is sealed inside a container with a dead space to accommodate a metabolic gas. The concentration of the gas in the dead space is monitored while the container remains sealed. In some embodiments, the container is permeable to the gas. In other embodiments, the biological material is the only growth medium in the container. The disposal of the biological material is in accordance with the monitored gas concentration. Preferably, the gas concentration is measured spectroscopically. A container for a biological material includes a main body that retains the biological material but that is permeable to a gas and a reservoir in fluid communication with the main body that is transparent to an optical wavelength that is absorbed by the gas.

Abstract: An optical system for determining the concentration of a metabolic gas in a container sealed to biological contamination and enclosing a biological material. The optical system has a broadly tunable coherent infrared light source, a detection module, and a control system connected to the light source and detection module and operates the light source, to receive and analyze the data provided by said detection module, and to process the data indicative of the concentration of said metabolic gas in said sealed container.

Abstract: A biological material such as platelets is sealed inside a container with a dead space to accommodate a metabolic gas. The concentration of the gas in the dead space is monitored while the container remains sealed. In some embodiments, the container is permeable to the gas. In other embodiments, the biological material is the only growth medium in the container. The disposal of the biological material is in accordance with the monitored gas concentration. Preferably, the gas concentration is measured spectroscopically. A container for a biological material includes a main body that retains the biological material but that is permeable to a gas and a reservoir in fluid communication with the main body that is transparent to an optical wavelength that is absorbed by the gas.