Patents by Inventor Morikazu Kito

Morikazu Kito has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dihydropyridine derivatives
    Patent number: 6610717
    Abstract: Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: August 26, 2003
    Assignee: Ajinomoto Co., Inc.
    Inventors: Akira Nakajo, Munetaka Tokumasu, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei
  • Protein having antithrombotic activity and method for producing the same
    Publication number: 20020198363
    Abstract: A method for producing a protein having an antithrombotic activity, which comprises replacing, in a protein that has an amino acid sequence having a homology of not less than 30% to the amino acid sequence of SEQ ID NO: 1 and forms a higher order structure composed of a first &bgr; strand (&bgr;1), a first &agr; helix (&agr;1), a second &agr; helix (&agr;2), a second &bgr; strand (&bgr;2), a loop, a third &bgr; strand (&bgr;3), a fourth &bgr; strand (&bgr;4) and a fifth &bgr; strand (&bgr;5) in this order from the amino terminus, at least one amino acid residue in a region from &agr;2 to &bgr;2 and/or a region from &bgr;3 to &bgr;4 so that electric charge of the amino acid residue is changed towards positive direction.
    Type: Application
    Filed: October 4, 2001
    Publication date: December 26, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Naoyuki Fukuchi, Morikazu Kito, Takashi Kayahara, Fumie Futaki, Kohki Ishikawa, Eiichiro Suzuki, Keiko Gondoh, Nobuhisa Shimba, Naoyuki Yamada
  • New dihydropyridine derivatives
    Publication number: 20020193605
    Abstract: Dihydropyridine derivatives represented by the following formula: 1
    Type: Application
    Filed: December 21, 2001
    Publication date: December 19, 2002
    Applicant: AJINOMOTO CO. INC
    Inventors: Akira Nakajo, Munetaka Tokumasu, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei
  • Dihydropyridine derivatives
    Publication number: 20020147222
    Abstract: Compounds having a selective N-type calcium channel antagonistic activity are provided.
    Type: Application
    Filed: December 20, 2001
    Publication date: October 10, 2002
    Applicant: AJINOMOTO CO. INC
    Inventors: Chika Nakanishi, Yoko Masuzawa, Masako Hagihara, Takashi Yamamoto, Hiroyuki Matsueda, Seiji Ohno, Seiji Niwa, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Tomoko Takeda, Yuki Kajigaya, Hajime Koganei
  • Dihydropyrimidine compounds and compositions containing the same
    Publication number: 20020143023
    Abstract: Dihydropyrimidine derivatives of the following formula or analogs thereof have selective N-type calcium channel antagonistic activity, and they are used as therapeutic agents for various diseases participating in the N-type calcium channels.
    Type: Application
    Filed: December 26, 2001
    Publication date: October 3, 2002
    Applicant: AJINOMOTO CO. INC
    Inventors: Seiji Ohno, Akiko Okajima, Seiji Niwa, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Yuki Kajigaya, Tomoko Takeda, Hajime Koganei
  • Antithrombotic agent and anti-von willebrand factor monoclonal antibody
    Publication number: 20020028204
    Abstract: A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which does not express bleeding action in an medicinally effective dose to exhibit antithrombotic action, is used as an active ingredient of an antithrombotic agent.
    Type: Application
    Filed: August 8, 2001
    Publication date: March 7, 2002
    Applicant: Ajinomoto Co., Inc.
    Inventors: Mitsuyo Nagano, Hiroshi Yamamoto, Morikazu Kito, Ryota Yoshimoto, Tsuyoshi Kobayashi
  • Dihydropyridine derivative
    Patent number: 6350762
    Abstract: Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type calcium channel.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: February 26, 2002
    Assignee: Ajinomoto Co., Inc.
    Inventors: Seiji Niwa, Seiji Ohno, Tomoyuki Onishi, Morikazu Kito, Akira Takahara, Yukitsugu Ono, Hisayuki Uneyama
  • Dihydropyridine compounds and composition containing the same
    Publication number: 20020002167
    Abstract: A dihydropyridine compound of the formula: 1
    Type: Application
    Filed: April 23, 2001
    Publication date: January 3, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Seiji Niwa, Seiji Ohno, Akira Takahara, Morikazu Kito
  • Antithrombotic agent and anti-von willebrand factor monoclonal antibody
    Patent number: 6280731
    Abstract: A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which does not express bleeding action in an medicinally effective dose to exhibit antithrombotic action, is used as an active ingredient of an antithrombotic agent.
    Type: Grant
    Filed: April 26, 1999
    Date of Patent: August 28, 2001
    Assignee: Ajinomoto Co., Inc.
    Inventors: Mitsuyo Nagano, Hiroshi Yamamoto, Morikazu Kito, Ryota Yoshimoto, Tsuyoshi Kobayashi
  • Antithrombotic agent and anti-von Willebrand factor monoclonal antibody
    Patent number: 5916805
    Abstract: A monoclonal antibody, which has reactivity with human von Willebrand factor, which has action to inhibit RIPA (ristocetin-induced platelet aggregation), BIPA (botrocetin-induced platelet aggregation), and SIPA (shear stress-induced platelet aggregation) of human platelet, and which does not express bleeding action in an medicinally effective dose to exhibit antithrombotic action, is used as an active ingredient of an antithrombotic agent.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: June 29, 1999
    Assignee: Ajinomoto Co., Inc.
    Inventors: Mitsuyo Nagano, Hiroshi Yamamoto, Morikazu Kito, Ryota Yoshimoto, Tsuyoshi Kobayashi
  • Peptide having anti-thrombus activity and method of producing the same
    Patent number: 5856126
    Abstract: A multimer peptide from a snake venom has an activity to inhibit binding between von Willebrand factor and platelets. The multimer peptide is used to obtain a single strand peptide which does not substantially cause decrease in platelets at a minimum dose for exhibiting the activity in vivo. The single strand peptide is obtained by allowing the multimer peptide to exist together with a protein-denaturing agent, and glutathione and/or cysteine, and thereby disconnecting disulfide bonds between peptide chains for constituting the multimer peptide while substantially preserving disulfide bonds within the peptide chains. Alternatively, the single strand peptide, a mutant thereof, or a part thereof is produced by genetic engineering techniques by using genes coding for them.
    Type: Grant
    Filed: March 20, 1996
    Date of Patent: January 5, 1999
    Assignee: Ajinomoto Co., Inc.
    Inventors: Naoyuki Fukuchi, Hiroshi Yamamoto, Mitsuyo Nagano, Morikazu Kito, Akiko Tanaka, Koichi Ishii, Tsuyoshi Kobayashi, Ryota Yoshimoto