Patents by Inventor Morita Iwami
Morita Iwami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11753385Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: October 6, 2021Date of Patent: September 12, 2023Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Publication number: 20220024883Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: October 6, 2021Publication date: January 27, 2022Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Patent number: 11155526Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: October 26, 2021Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 11066374Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: July 20, 2021Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 10980813Abstract: Provided is an antifungal composition containing a cyclic N-sulfonylamine compound, a cyclic N-sulfonylimine compound or a cyclic N-sulfonyloxaziridine compound, each having an antifungal activity, as an active ingredient. An antifungal composition containing a compound represented by the formula (1): wherein ring A is an optionally further substituted 5- to 7-membered heterocycle, and the 5- to 7-membered heterocycle is optionally condensed with 1 or 2 rings selected from an optionally substituted benzene ring and an optionally substituted 5- to 7-membered heterocycle, X is —N?, —NR2— or —O—; Y1 is a hydrogen atom, and Y2 is a hydroxy group or Y1 and Y2 may be joined to form a bond or —O—; R1 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and R2 is a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof as an active ingredient.Type: GrantFiled: February 27, 2018Date of Patent: April 20, 2021Assignee: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 10703732Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: July 7, 2020Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 10618876Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: September 21, 2018Date of Patent: April 14, 2020Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Publication number: 20190216820Abstract: Provided is an antifungal composition containing a cyclic N-sulfonylamine compound, a cyclic N-sulfonylimine compound or a cyclic N-sulfonyloxaziridine compound, each having an antifungal activity, as an active ingredient. An antifungal composition containing a compound represented by the formula (1): wherein ring A is an optionally further substituted 5- to 7-membered heterocycle, and the 5- to 7-membered heterocycle is optionally condensed with 1 or 2 rings selected from an optionally substituted benzene ring and an optionally substituted 5- to 7-membered heterocycle, X is —N?, —NR2— or —O—; Y1 is a hydrogen atom, and Y2 is a hydroxy group or Y1 and Y2 may be joined to form a bond or —O—; R1 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and R2 is a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof as an active ingredient.Type: ApplicationFiled: February 27, 2018Publication date: July 18, 2019Applicant: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190152929Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: May 23, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190023669Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190023667Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20190023668Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: September 21, 2018Publication date: January 24, 2019Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Patent number: 10106509Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: GrantFiled: February 26, 2016Date of Patent: October 23, 2018Assignees: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 9988396Abstract: Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a production method thereof. A compound represented by the formula 1: wherein X is a single bond, —C(H)(R6)— or —C(H)(R7)—C(H)(R8)—; and R1-R8 are each independently a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, or a salt thereof.Type: GrantFiled: January 26, 2017Date of Patent: June 5, 2018Assignee: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko Ishikawa, Morita Iwami
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Patent number: 9896457Abstract: Provided are a compound having a novel mother nucleus, which can be a promising drug discovery seed compound, use thereof as an antifungal agent, and a production method thereof and the like. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, and an antifungal agent containing same, and the like.Type: GrantFiled: August 29, 2014Date of Patent: February 20, 2018Assignees: OP Bio Factory Co., Ltd., Seed Research Institute Co., Ltd.Inventors: Morita Iwami, Sachi Kato, Yoshimi Matsumoto, Hideo Naoki
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Publication number: 20180037555Abstract: Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1): wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2): wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.Type: ApplicationFiled: February 26, 2016Publication date: February 8, 2018Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20170327513Abstract: Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a production method thereof. A compound represented by the formula 1: wherein X is a single bond, —C(H) (R6)— or —C(H) (R7)—C(H)(R8)—; and R1-R8 are each independently a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, or a salt thereof.Type: ApplicationFiled: January 26, 2017Publication date: November 16, 2017Applicant: SEED RESEARCH INSTITUTE CO., LTD.Inventors: Teruhiko ISHIKAWA, Morita IWAMI
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Publication number: 20160207937Abstract: Provided are a compound having a novel mother nucleus, which can be a promising drug discovery seed compound, use thereof as an antifungal agent, and a production method thereof and the like. A compound represented by the following formula: or a pharmaceutically acceptable salt thereof, and an antifungal agent containing same, and the like.Type: ApplicationFiled: August 29, 2014Publication date: July 21, 2016Applicants: OP BIO FACTORY CO., LTD., SEED RESEARCH INSTITUTE CO., LTD.Inventors: Morita IWAMI, Sachi KATO, Yoshimi MATSUMOTO, Hideo NAOKI
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Publication number: 20040053323Abstract: Methods of screening for iNOS activity inhibitors are provided using the binding activity of candidate compounds towards the iNOS monomer (or a mutant thereof) as an index. Dimerization of iNOS is the final step in the acquisition of iNOS enzyme activity. The screening methods according to this invention enable quick screening of iNOS inhibitory compounds that have excellent specificity and rapid action properties through simple manipulations.Type: ApplicationFiled: January 15, 2003Publication date: March 18, 2004Inventors: Yoshinori Ishii, Yoshiko Ueda, Morita Iwami, Hiroyuki Arakawa, Yoshitada Notsu
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Patent number: 5677141Abstract: The present invention provides a process for producing 7-aminocephem compounds or salts thereof.Type: GrantFiled: September 30, 1994Date of Patent: October 14, 1997Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Takao Isogai, Masao Fukagawa, Morita Iwami, Ichiro Aramori, Hitoshi Kojo