Abstract: Method for calibrating an irradiation device (2) for an apparatus (1) for additively manufacturing three-dimensional objects by means of successive layerwise selective irradiation and consolidation of layers of a build material which can be consolidated by means of an energy beam (6, 7), which irradiation device (2) comprises at least a first and a second irradiation unit (3, 4) adapted to guide at least a first and a second energy beam (7), wherein at least two first and two second calibration patterns (15) are generated, wherein the at least two first calibration patterns (14) are generated in at least two different first positions via the first energy beam (6) and the at least two second calibration patterns (15) are generated in at least two different second positions via the second energy beam (7) and position information are determined relating to the positions of the at least two first and second calibration patterns (14, 15) and calibration information are generated relating to a calibration status of

Abstract: Method for calibrating an irradiation device for additively manufacturing three-dimensional objects by successive layerwise selective irradiation and consolidation of layers of a build material which can be consolidated by means of an energy beam, which irradiation device comprises a first and a second irradiation unit adapted to guide a first and a second energy beam, wherein at least two first and two second calibration patterns are generated, wherein the at least two first calibration patterns are generated in at least two different first positions via the first energy beam and the at least two second calibration patterns are generated in at least two different second positions via the second energy beam and position information are determined relating to the positions of the at least two first and second calibration patterns and calibration information are generated relating to a calibration status of the irradiation device based on the determined position information.

Abstract: An adjustment to an irradiation parameter corresponding to a first irradiation unit and/or a second irradiation unit of an irradiation device of an additive manufacturing apparatus may be performed based at least in part on a simulation. The simulation may include simulating generation of a plurality of first calibration patterns by the first irradiation unit and a plurality of second calibration patterns by the second irradiation unit with a simulated change to the irradiation parameter of the irradiation device, and determining a calibration quality value based at least in part on position information relating to the plurality of first calibration patterns and the plurality of second calibration patterns. The calibration quality value may include an indication as to whether a calibration quality of the apparatus would be improved as a result of the adjustment to the irradiation parameter.

Abstract: The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1- and/or TASK-3-blocking properties.

Abstract: To treat parts printed by means of 3D printing from the powder bed, they are inserted into a trough belt conveyor which transports and circulates the parts and in which the parts are acted on by a fluid jet during the transport.

Abstract: Methods for calibrating an irradiation device for an apparatus for additively manufacturing three-dimensional objects include generating at least two first and two second calibration patterns, in at least two different first positions and at least two different second positions; determining position information relating to the positions of the calibration patterns; generating a calibration quality value relating to a calibration status of the irradiation device; simulating at least two first calibration patterns and at least two second calibration patterns based on at least one changed irradiation parameter; determining a calibration quality value for the simulated calibration patterns; and repeating the simulation and determination of the calibration quality value until a maximum or minimum calibration quality value is reached.

Abstract: The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Abstract: The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle.

Abstract: The invention relates to a process for producing pharmaceutical dosage forms containing potent and selective TASK-1 and/or TASK-3 channel inhibitors, and to the use of the dosage forms obtained by the said production process to treat and/or prevent breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring.

Abstract: The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Abstract: Powder module (1) for an apparatus (2) for additively manufacturing three-dimensional objects, which powder module (1) comprises a holding device (5) adapted to hold a build plate (3) of the powder module (1), wherein the holding device (5) comprises at least one clamping unit (6) connectable with and disconnectable from a recess (7) in the build plate (3), wherein the clamping unit (6) is moveable between a first position in which the clamping unit (6) is connected with the build plate (3) and a second position in which the clamping unit (6) is disconnected from the recess (7).

Abstract: Methods for calibrating an irradiation device for an apparatus for additively manufacturing three-dimensional objects include generating at least two first and two second calibration patterns, in at least two different first positions and at least two different second positions; determining position information relating to the positions of the calibration patterns; generating a calibration quality value relating to a calibration status of the irradiation device; simulating at least two first calibration patterns and at least two second calibration patterns based on at least one changed irradiation parameter; determining a calibration quality value for the simulated calibration patterns; and repeating the simulation and determination of the calibration quality value until a maximum or minimum calibration quality value is reached.

Abstract: The present application relates to novel (imidazo[1,2-a]pyridin-3-yl)methyl-substituted diazaheterobicyclic compounds, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of respiratory disorders including sleep-related respiratory disorders such as obstructive sleep apnoea and central sleep apnoea and snoring. The present application further relates to a method of discovering a compound having TASK-1-and/or TASK-3-blocking properties.

Abstract: Powder module (1) for an apparatus (2) for additively manufacturing three-dimensional objects, which powder module (1) comprises a holding device (5) adapted to hold a build plate (3) of the powder module (1), wherein the holding device (5) comprises at least one clamping unit (6) connectable with and disconnectable from a recess (7) in the build plate (3), wherein the clamping unit (6) is moveable between a first position in which the clamping unit (6) is connected with the build plate (3) and a second position in which the clamping unit (6) is disconnected from the recess (7).

Abstract: Method for calibrating an irradiation device for additively manufacturing three-dimensional objects by successive layerwise selective irradiation and consolidation of layers of a build material which can be consolidated by means of an energy beam, which irradiation device comprises a first and a second irradiation unit adapted to guide a first and a second energy beam, wherein at least two first and two second calibration patterns are generated, wherein the at least two first calibration patterns are generated in at least two different first positions via the first energy beam and the at least two second calibration patterns are generated in at least two different second positions via the second energy beam and position information are determined relating to the positions of the at least two first and second calibration patterns and calibration information are generated relating to a calibration status of the irradiation device based on the determined position information.

Abstract: The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring.

Abstract: The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Abstract: The invention relates to new pharmaceutical dosage forms containing potent and selective TASK-1 and/or TASK-3 channel inhibitors, and the use of same to treat and/or prevent breathing disorders including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring.

Abstract: The invention relates to new pharmaceutical dosage forms containing potent and selective TASK-1 and/or TASK-3 channel inhibitors, and the use of same to treat and/or prevent breathing disorders including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Abstract: Separating device (1) for separating at least one object (2-10) from an object carrier (11), in particular for separating an additively built three-dimensional object (2-10) from a build plate, preferably built via an apparatus for additively manufacturing three-dimensional objects (2-10) by means of successive layerwise selective irradiation and consolidation of layers of a build material which can be consolidated by means of an energy source, which separating device (1) comprises at least one separating element (12) that is adapted to remove material for separating the at least one object (2-10) from the object carrier (11), wherein a control unit (15) is provided that is adapted to control at least one operational parameter of the at least one separating device (1), in particular a feed rate and/or a cutting rate of the separating element (12), dependent on at least one object parameter of the at least one object (2-10).