Patents by Inventor Moritz Johannes Schmidt

Moritz Johannes Schmidt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Direct, programmable detection of epigenetic DNA cytosine modifications using TAL effectors
    Patent number: 9879315
    Abstract: Methods for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of the cytosine residue of interest or (ii) an unmodified cytosine residue of interest, the methods making use of the capability of transcription-activator-like effector (TALE) proteins to preferentially bind with strong affinity to nucleic acid sequences containing non-modified cytosine residues or 5-methyl modified cytosine residues, and to bind, if at all, with only strongly reduced affinity to nucleic acid sequences containing 5-hydroxymethyl modified cytosine residues. The present invention further relates to respective uses of TALE proteins for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of the cytosine residue of interest or (ii) the unmodified cytosine residue of interest.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: January 30, 2018
    Assignee: Universität Konstanz
    Inventors: Daniel Summerer, M. Grzegorz Kubik, Moritz Johannes Schmidt