Patents by Inventor Moritz THRAN

Moritz THRAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF REDUCING THE IMMUNOSTIMULATORY PROPERTIES OF IN VITRO TRANSCRIBED RNA
    Publication number: 20240102065
    Abstract: The present invention provides a method of reducing the immunostimulatory properties of an in vitro transcribed RNA by producing the in vitro transcribed RNA comprising a 3? terminal A nucleotide. Hereby, the circular DNA template used to generate the in vitro transcribed RNA has been linearized using a type IIS endonuclease. The invention further provides pharmaceutical compositions comprising the vitro transcribed RNA comprising a 3? terminal A nucleotide according to the invention for use in therapy.
    Type: Application
    Filed: January 26, 2022
    Publication date: March 28, 2024
    Applicant: CureVac SE
    Inventors: Moritz THRAN, Andreas THESS, Fabian EBER, Dipankar BHANDARI
  • NOVEL ARTIFICIAL NUCLEIC ACID MOLECULES
    Publication number: 20220233568
    Abstract: The present invention provides artificial nucleic acid molecules comprising novel combinations of 5? and 3? untranslated region (UTR) elements. The inventive nucleic acid molecules are preferably characterized by increased expression efficacies of coding regions operably linked to said UTR elements. The artificial nucleic acids can be used for treatment or prophylaxis of various diseases. The invention further provides (pharmaceutical) compositions, vaccines and kits comprising said artificial nucleic acid molecules. Further, in vitro methods for preparing artificial nucleic acid molecules according to the invention are provided.
    Type: Application
    Filed: October 17, 2018
    Publication date: July 28, 2022
    Inventors: Thomas SCHLAKE, Andreas THESS, Moritz THRAN, Frédéric CHEVESSIER-TÜNNESEN, Marion PÖNISCH