Abstract: Antibodies that bind Her2, EGFR, Trop2, CDH3 or other TAAs containing a triple mutation at L234A, L235A, and L328C and methods of making such triple mutated antibodies are disclosed herein. Consequently, the triple mutated antibodies contain a modified effector function through Fc silencing and are capable of site-specific conjugation at L328C to form an antibody-drug-conjugate (ADC) which can be administered to patients and provide a method of treating cancer, immunological and neurological disorders.

Abstract: Antibodies that bind Her2, EGFR, Trop2, CDH3 or other TAAs containing a triple mutation at L234A, L235A, and L328C and methods of making such triple mutated antibodies are disclosed herein. Consequently, the triple mutated antibodies contain a modified effector function through Fc silencing and are capable of site-specific conjugation at L328C to form an antibody-drug-conjugate (ADC) which can be administered to patients and provide a method of treating cancer, immunological and neurological disorders.

Abstract: An element backup including a first ring defining an axis; a first parting line through the first ring, the first parting line having a first plurality of generally axially extending segments and a first generally non-axially extending segment extending between the first plurality of axially extending segments; a second ring defining an axis; a second parting line through the second ring, the second parting line having a second plurality of generally axially extending segments and a second generally non-axially extending segment extending between the second plurality of axially extending segments; and an interconnection releasably securing the first and second rings to one another.

Abstract: An element backup including a first ring defining an axis; a first parting line through the first ring, the first parting line having a first plurality of generally axially extending segments and a first generally non-axially extending segment extending between the first plurality of axially extending segments; a second ring defining an axis; a second parting line through the second ring, the second parting line having a second plurality of generally axially extending segments and a second generally non-axially extending segment extending between the second plurality of axially extending segments; and an interconnection releasably securing the first and second rings to one another.

Abstract: Antibodies that bind Her2, EGFR, Trop2, CDH3 or other TAAs containing a triple mutation at L234A, L235A, and L328C and methods of making such triple mutated antibodies are disclosed herein. Consequently, the triple mutated antibodies contain a modified effector function through Fc silencing and are capable of site-specific conjugation at L328C to form an antibody-drug-conjugate (ADC) which can be administered to patients and provide a method of treating cancer, immunological and neurological disorders.

Abstract: An element backup including a first ring defining an axis; a first parting line through the first ring, the first parting line having a first plurality of generally axially extending segments and a first generally non-axially extending segment extending between the first plurality of axially extending segments; a second ring defining an axis; a second parting line through the second ring, the second parting line having a second plurality of generally axially extending segments and a second generally non-axially extending segment extending between the second plurality of axially extending segments; and an interconnection releasably securing the first and second rings to one another.

Abstract: A packer system includes a gauge ring, an expanding ring arranged adjacent to the gauge ring, a back-up ring, a packer element arranged adjacent to the back-up ring, and a support ring arranged between the back-up ring and the expanding ring. The support ring promotes radial outward expansion of the expanding ring.

Abstract: A packer system includes a gauge ring, an expanding ring arranged adjacent to the gauge ring, a back-up ring, a packer element arranged adjacent to the back-up ring, and a support ring arranged between the back-up ring and the expanding ring. The support ring promotes radial outward expansion of the expanding ring.