Abstract: The present disclosure relates to anti-glyco-cMET antibodies and antigen binding fragments thereof that specifically bind to a cancer-specific glycosylation variant of cMET and related fusion proteins and antibody-drug conjugates, as well as nucleic acids encoding such biomolecules. The present disclosure further relates to use of the antibodies, antigen-binding fragments, fusion proteins, antibody-drug conjugates and nucleic acids for cancer therapy.

Abstract: A system includes a source of sheet material and a conversion machine. The conversion machine is configured to receive the sheet material and to form the sheet material into a fill material. The conversion machine further includes a cutting system configured to selectively cut the fill material either partially or completely to form two pieces of the fill material. When the cutting system partially cuts the fill material, uncut portions of the fill material remain between the two pieces of the fill material. When the cutting system completely cuts the fill material, no uncut portions remain between the two pieces of the fill material.

Abstract: An example method includes presenting a user interface facilitating a creation of a video from an image associated with a first media item of a plurality of media items, wherein the first media item comprises the image and a video clip that are captured concurrently, receiving user input via the user interface, wherein the user input comprises a selection of a selectable control element presented in the user interface, and upon receiving the user input, presenting the video clip of the first media item in the user interface, wherein the video clip of the first media item is played in the user interface and comprises video content from before and after the image is captured.

Abstract: A sports line kit includes a plurality of tape lines, including longer lines that provide sidelines, medium length lines that provide baselines and kitchen lines, and shorter lines that provide service lines. Indicia are included on the tape lines for quick and convenient assembly of the sports court. Each tape line has one adhesive side and one slip-resistant side. In at least some embodiments, the kit further includes balls, paddles, rackets and/or a sports net. In at least some additional embodiments, the kit further includes a line gauge configured to measure the diagonal of a court assembled with the sports line kit.

Abstract: The dental care device comprises a drive mechanism and a customized mouthpiece. The drive mechanism comprises a first motor connection point, a second motor connection point, and one or more motors. The customized mouthpiece is configured to couple with the drive mechanism, and comprises: a first region including a first mouthpiece connection point configured to engage with the first motor connection point; a second region including a second mouthpiece connection point configured to engage with the second motor connection point; and a third region connection the first region and the second region, such that the first region can be moved independently of the second region.

Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

Abstract: Systems and methods for performing operations based on LIDAR communications are described. An example device may include one or more processors and a memory coupled to the one or more processors. The memory includes instructions that, when executed by the one or more processors, cause the device to receive data associated with a modulated optical signal emitted by a transmitter of a first LIDAR device and received by a receiver of a second LIDAR device coupled to a vehicle and the device, generate a rendering of an environment of the vehicle based on information from one or more LIDAR devices coupled to the vehicle, and update the rendering based on the received data. Updating the rendering includes updating an object rendering of an object in the environment of the vehicle. The instructions further cause the device to provide the updated rendering for display on a display coupled to the vehicle.

Abstract: A method and satellite for capture-less management of orbital debris objects, include controlling a satellite having opposing thrusters to be maintained at a predetermined distance from an orbital debris object to be managed, i.e., paired with the orbital debris object. Management may include fine tracking of the orbital debris object and/or operating the opposing thrusters to apply force to the orbital debris object to generate a model of the orbital debris object, to change the attitude of the orbital debris object, to deorbit the orbital debris object, and/or breakup the orbital debris object.

Abstract: Aspects of the present disclosure are directed to systems, methods, and computer readable media for regulating digital therapeutic content for provision. A computing system may identify a digital therapeutic content to be provided via a network. The computing system may apply the digital therapeutic content to a machine learning (ML) model having a set of weights. The computing system may determine, from applying the digital therapeutic content to the ML model, an indication as of one of compliance or non-compliance. The computing system may store, using one or more data structures, an association between the digital therapeutic content and the indication used to control provision of the digital therapeutic content via the network, by (i) restricting the digital therapeutic content from provision responsive to determining the indication of non-compliance and (ii) permitting the digital therapeutic content to be provided responsive to determining the indication of compliance.

Abstract: The present disclosure provides for a wrist arthroplasty system and method that enable an expedient surgical procedure, maintain wrist motion, and reduce the likelihood of implant loosening. The system includes a capitate implant, a radial implant, and a resection instrument. The capitate implant includes a convex head formed to interface with a concave socket of the radial implant. The capitate implant includes a single stem formed to be secured within a patient's capitate bone. The radial implant includes lips formed to increase wrist joint motion and to help prevent dislocation of the capitate implant from the radial implant. The resection instrument may be used in combination as a measurement tool for determining the proper implant size, a guide for properly positioning the implants, and a trial tool for testing trial implant components before securing the final radial and capitate implants.

Abstract: Aspects of the present disclosure are directed to systems, methods, and computer readable media for configuring generation of digital therapeutic content for provision. The system can receive a text input including one or more parameters identifying an audience and at least one domain. The system can identify content items generated by corresponding generative transformer models each using a prompt created based on the text input. The system can select, from a set of risk models for the domains, at least one risk model corresponding to the at least one domain. The system can apply the at least one risk model to each content item of the set of content items to determine a risk score. The system can select a content item based on the risk score of the content item. The system can present the content item including the respective digital therapeutic content.

Abstract: Aspects of the present disclosure are directed to systems, methods, and computer readable media for regulating digital therapeutic content for provision. A computing system may identify a digital therapeutic content to be provided via a network. The computing system may apply the digital therapeutic content to a machine learning (ML) model having a set of weights. The computing system may determine, from applying the digital therapeutic content to the ML model, an indication as of one of compliance or non-compliance. The computing system may store, using one or more data structures, an association between the digital therapeutic content and the indication used to control provision of the digital therapeutic content via the network, by (i) restricting the digital therapeutic content from provision responsive to determining the indication of non-compliance and (ii) permitting the digital therapeutic content to be provided responsive to determining the indication of compliance.

Abstract: Aspects of the present disclosure are directed to systems, methods, and computer readable media for regulating digital therapeutic content for provision. A computing system may identify a digital therapeutic content to be provided via a network. The computing system may apply the digital therapeutic content to a machine learning (ML) model having a set of weights. The computing system may determine, from applying the digital therapeutic content to the ML model, an indication as of one of compliance or non-compliance. The computing system may store, using one or more data structures, an association between the digital therapeutic content and the indication used to control provision of the digital therapeutic content via the network, by (i) restricting the digital therapeutic content from provision responsive to determining the indication of non-compliance and (ii) permitting the digital therapeutic content to be provided responsive to determining the indication of compliance.

Abstract: Print materials described herein include a first polymerization initiator comprising an initiator material having a thermal decomposition rate and a peak photo-initiated decomposition rate, wherein the thermal dissociation rate is higher than the peak photo-initiated decomposition rate; a vinylic monomer; a polyfunctional monomer; scattering particles; and quantum dots. Methods of making a quantum dot material using such print materials, and of incorporating into light emitting devices, are also described.

Abstract: Aspects of the present disclosure are directed to systems, methods, and computer readable media for executing actions for events associated with use of applications. A computing system can identify free text associated with an application to be evaluated for at least one of a plurality of events associated with a use of the application. The computing system can apply the free text to a machine learning (ML) architecture. The computing system can determine, based on applying the free text to the ML architecture, a value indicating a likelihood of occurrence of an event associated with the use of the application. The computing system can provide to a generative ML model, a model input based on the free text and the value, to obtain data for an electronic document characterizing the event. The computing system can execute an action using the data for the electronic document.

Abstract: An ablation catheter comprises: an elongated catheter body extending longitudinally between a proximal end and a distal end along a longitudinal axis; a distal member disposed adjacent the distal end, the distal member including an ablation element to ablate a biological member; one or more acoustic transducers disposed in the distal member and each configured to direct an acoustic signal toward a respective target ablation region and receive reflection echoes therefrom; and an acoustic redirection member disposed in the distal member to at least partially redirect the acoustic signal from at least one of the acoustic transducers toward a tissue target. The distal member includes a most-distal portion, a proximal portion, and a deflectable portion between the most-distal portion and proximal portion to permit deflection between the most-distal portion and proximal portion of the distal member. The transducers and redirection member are mounted on opposite sides of the deflectable portion.

Abstract: Provided are polynucleotides encoding inactivated cell surface receptors. Also provided are genetically engineered induced pluripotent stem cells (iPSCs) and derivative cells thereof expressing a chimeric antigen receptor (CAR) and methods of using the same. Also provided are compositions, polypeptides, vectors, and methods of manufacturing.

Abstract: Electric fields that can cause corrosion of contacts can be compensated for by embodiments of the present invention. For example, voltage waveforms at the contacts can be made to have a zero volt average, and therefore have a zero net electric field. Galvanic voltages generated by dissimilar metals used by a contact and a housing can generate an electric field, and currents motivated by the galvanic electric field can be blocked by capacitively coupling the contacts to their corresponding circuits.

Abstract: Aspects of the present disclosure are directed to systems, methods, and computer readable media for generating messages targeted to address conditions in users. A computing system may identify (i) a condition of a user to be addressed and (ii) one or more parameters defining messages to be presented via an application towards achieving an endpoint associated with the condition for the user. The computing system may generate a prompt using the condition and the one or more parameters in accordance with a template. The computing system may apply the prompt to a generative model to output a message identifying at least one activity toward achieving the endpoint. The generative model may be trained using a corpus. The computing system may provide, the message for presentation to prompt the user to perform the activity via the application towards achieving the endpoint to address the condition.