Abstract: The present disclosure relates to anti-glyco-cMET antibodies and antigen binding fragments thereof that specifically bind to a cancer-specific glycosylation variant of cMET and related fusion proteins and antibody-drug conjugates, as well as nucleic acids encoding such biomolecules. The present disclosure further relates to use of the antibodies, antigen-binding fragments, fusion proteins, antibody-drug conjugates and nucleic acids for cancer therapy.

Abstract: The subject invention pertains to a modified MC1R peptide ligand comprising a peptide that is a melanocortin 1 receptor (MC1R) ligand and a functionality or linker, such as a click functionality, for conjugation to a surface or agent. The modified MC1R peptide ligand can be coupled, e.g., via a click reaction with a complementary click functionality attached, to a moiety to form an MC1R-targeted agent. Drugs, contrast agents, polymers, particles, micelles, surfaces of larger structures, or other moieties can be targeted to the MC1R. The subject invention also pertains to a MC1R peptide ligand-micelle complex comprising a peptide that is a melanocortin 1 receptor ligand connected via a click reaction product to a micelle. The micelle is stable in vivo and can target melanoma tumor cells by association of the peptide ligand with the MC1R or the tumor and selectively provide a detectable and/or therapeutic agent (such as an imageable contrast agent and/or anti-cancer agent) selectively to the tumor cell.

Abstract: The dental care device comprises a drive mechanism and a customized mouthpiece. The drive mechanism comprises a first motor connection point, a second motor connection point, and one or more motors. The customized mouthpiece is configured to couple with the drive mechanism, and comprises: a first region including a first mouthpiece connection point configured to engage with the first motor connection point; a second region including a second mouthpiece connection point configured to engage with the second motor connection point; and a third region connection the first region and the second region, such that the first region can be moved independently of the second region.

Abstract: Aspects of the present disclosure are directed to systems, methods, and computer readable media for generating messages targeted to address conditions in users. A computing system may identify (i) a condition of a user to be addressed and (ii) one or more parameters defining messages to be presented via an application towards achieving an endpoint associated with the condition for the user. The computing system may generate a prompt using the condition and the one or more parameters in accordance with a template. The computing system may apply the prompt to a generative model to output a message identifying at least one activity toward achieving the endpoint. The generative model may be trained using a corpus. The computing system may provide, the message for presentation to prompt the user to perform the activity via the application towards achieving the endpoint to address the condition.

Abstract: The present disclosure relates to anti-glyco-MUC4 antibodies and antigen binding fragments thereof that specifically bind to a cancer-specific glycosylation variant of MUC4 and related fusion proteins and antibody-drug conjugates, as well as nucleic acids encoding such biomolecules. The present disclosure further relates to use of the antibodies, antigen-binding fragments, fusion proteins, antibody-drug conjugates and nucleic acids for cancer therapy.

Abstract: Certain aspects of the present disclosure provide techniques and apparatus for executing a workload on a computing device based on an approximation of a target function. An example method generally includes generating a plurality of sample points from a multi-dimensional space representing domain of a target function. A plurality of sparse matrices is generated from the plurality of sample points, each respective sparse matrix being generated based on known non-zero coefficients of the target function. A plurality of transformed sparse matrices representing a relationship between Chebyshev coefficients of the target function and the plurality of sample points after applying lower dimensional cosine transformations are generated. An approximation of the target function is generated based on the plurality of transformed sparse matrices. An output of at least a portion of a neural network may be generated based on the approximation of the target function.

Abstract: A rim for a bicycle wheel includes a radially inner portion disposed along an inner circumference of the rim, a first sidewall, a second sidewall spaced apart from the first sidewall, a radially outer tire engaging portion disposed along an outer circumference of the rim, and an opening. The first sidewall, the second sidewall, the radially outer tire engaging portion, the radially inner portion, or any combination thereof includes a composite laminate. The composite laminate includes one or more compressed layers of a first composite material, which includes a matrix of a polymer-based material and natural fibers for a reinforcing material, and one or more compressed layers of a second composite material that is different than the first composite material. The opening extends through at least one layer of the one or more compressed layers of the second composite material, such that the second composite material surrounds the opening.

Abstract: The present disclosure relates to anti-glyco-LAMP1 antibodies and antigen binding fragments thereof that specifically bind to a cancer-specific glycosylation variant of LAMP1 and related fusion proteins and antibody-drug conjugates, as well as nucleic acids encoding such biomolecules. The present disclosure further relates to use of the antibodies, antigen-binding fragments, fusion proteins, antibody-drug conjugates and nucleic acids for cancer therapy.

Abstract: The invention features a method of producing aggregates of a plurality of cell populations (e.g., a first population of cells and a second population of cells). The method includes agitating a liquid medium that contains the cells in a bioreactor. These aggregates may be used for subsequent downstream applications, such as encapsulation in a biocompatible scaffold to form an engineered tissue construct.

Abstract: A patient turning apparatus is disclosed. The apparatus comprises a reconfigurable support platform comprising a plurality of laterally extending support slats configured for pivotal movement about a longitudinally extending central region of the platform. At least one support slat is configured to follow a pivotal movement of a longitudinally adjacent support slat about the central region, through at least a portion of a pivotal range of movement of the longitudinally adjacent support slat. The apparatus further comprises means operable to control pivotal movement of at least one support slat of the platform about the central region.

Abstract: A rim for a bicycle wheel includes a radially inner portion disposed along an inner circumference of the rim, a first sidewall, and a second sidewall spaced apart from the first sidewall. The first sidewall and the second sidewall extend radially outward from the radially inner portion. The rim also includes a radially outer tire engaging portion disposed along an outer circumference of the rim. The radially outer tire engaging portion extends from the first sidewall and the second sidewall, respectively. The rim also includes an opening through the radially inner portion at a first circumferential position along the inner circumference. An air valve of the bicycle wheel is positionable through the opening. The rim also includes a receptacle for a sensor device within the radially inner portion at a second circumferential position along the inner circumference. The second circumferential position is different than the first circumferential position.

Abstract: Safe lifting devices configured for lifting of a fallen patient from a surface and for a transport of the patient are disclosed herein. The devices comprise a class 1 lever including two larger wheels disposed about parallel at a fulcrum of the lever with each of the two larger wheels having shorter load leverage arms and longer effort leverage arms extending radially outward and defining a lever angle of greater than 90°. Each of the larger wheels disposed at the fulcrum includes a smaller rolling wheel attached to each larger wheel by an axle and a medium rolling wheel attached to each larger wheel by a different axle. When an operator pulls down the longer effort leverage arms the patient is safely lifted.

Abstract: An apparatus for preparing a liquid preparation uses a two-part system. A first part includes a first reagent and a second part includes a second reagent. The first reagent and the second reagent react when mixed to form an active ingredient of the liquid preparation. The liquid preparation is a diluent. The apparatus includes a primary chamber for receiving a quantity of the first part, a quantity of the second part and a quantity of the diluent, a reagent inlet for admitting the first part and the second part to the primary chamber, a diluent inlet connectable to a diluent supply for admitting the diluent to the primary chamber, an outlet for releasing the liquid preparation from the primary chamber, and a flow controller to admit a pre-determined volume of diluent to the primary chamber in a pre-determined time period when the diluent inlet is connected to a diluent supply.

Abstract: A system and method for assessing digital interactions with a digital third party accounts can include receiving user account credentials for authentication with an external computing system, storing the user account credentials in association with a authentication token and communicating the authentication token to a computing device of an external application service; receiving, through a programmatic communication interface, a request that references the authentication token and digital interaction details; programmatically authenticating, using the stored user account credentials, as a user account with the external computing system and retrieving account data; processing the account data in combination with the digital interaction details and thereby generating a digital interact assessment; and initiating execution of a digital interaction based in part on the digital interaction assessment.

Abstract: An apparatus is disclosed for preparing a liquid preparation using a two-part system comprising a first part including a first reagent and a second part including a second reagent, wherein the first reagent and the second reagent react when mixed to form an active ingredient of the liquid preparation. The apparatus comprising a mixing funnel having a reaction chamber, an inlet region for admitting a quantity of the first part and a quantity of the second part into the reaction chamber, for example from a dispensing capsule, to form a reagent mixture in the reaction chamber in use, and an outlet comprising at least one restriction orifice for releasing the reagent mixture from the reaction chamber at a controlled rate, and a primary chamber arranged to receive the reagent mixture from the reaction chamber through the restriction orifice.

Abstract: Various embodiments of the present invention provide microchannel and electrode configurations by which uniform electric current density within a microchannel is achieved. The invention provides this and other advantages.

Abstract: The various embodiments described herein include methods, devices, and systems for customizing dental care. In one aspect, a 3-D dental scan of the interior of a user's mouth is received, which includes upper teeth and gums and lower teeth and gums in a closed mouth position. An updated 3-D representation of the interior of the user's mouth is generated, including the upper teeth and gums and the lower teeth and gums in an open mouth position. A customized mouthpiece is generated, based on the updated 3-D representation of the user's mouth, and the customized mouthpiece is configured to be received in the user's mouth in the open mouth position.

Abstract: The various embodiments described herein include methods, devices, and systems for customizing dental care. In one aspect, personalized toothbrush devices are 3-D printed for a plurality of users. A 3-D dental model of a respective user's mouth is obtained, and a configuration for a mouthpiece of a respective personalized toothbrush device is determined. The respective personalized toothbrush device is 3-D printed, and includes a top cleaning tray, a bottom cleaning tray, and a set of cleaning elements, each customized based at least in part on the 3-D dental model of the respective user's mouth. Each personalized toothbrush device is 3-D printed for each respective user of the plurality of users, and is different from every other user's personalized toothbrush device.

Abstract: Approaches for the foil-based metallization of solar cells and the resulting solar cells are described. In an example, a solar cell includes a substrate. A plurality of alternating N-type and P-type semiconductor regions is disposed in or above the substrate. A conductive contact structure is disposed above the plurality of alternating N-type and P-type semiconductor regions. The conductive contact structure includes a plurality of metal seed material regions providing a metal seed material region disposed on each of the alternating N-type and P-type semiconductor regions. A metal foil is disposed on the plurality of metal seed material regions, the metal foil having anodized portions isolating metal regions of the metal foil corresponding to the alternating N-type and P-type semiconductor regions.

Abstract: Disclosed are TATE derivatives having a linker between the TATE moiety and a macrocyclic radionuclide chelating moiety. Methods of synthesis and use are also disclosed. The compounds preferably exhibit a ratio of kidney: liver uptake by a subject within 24 hours of 5 or less, 3 or less, 1 or less, 0.5 or less, preferably from 2:1 to 1:2.