Abstract: The present disclosure relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The disclosure further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

Abstract: The present invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

Abstract: The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is —CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or —ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.

Abstract: The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is —CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or —ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.

Abstract: The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is —CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or —ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.

Abstract: The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is —CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or —ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.

Abstract: The invention relates to a method of cutting off laminate layers for use in a fiber-reinforced laminate object comprising a number of combined laminate layers, wherein, along a section of the at least one rim of the laminate layer, a tapering cut is performed through the thickness of the laminate layer, whereby the thickness of the laminate layer is reduced. Since not only the number of laminate layers, but also the thickness of the individual laminate layers are reduced, a laminate layer is accomplished that can be used in a laminate object, by which both the issues of areas rich in resin, air pockets and the risk of delamination are reduced. The invention also relates to a laminate layer for use in a fiber-reinforced laminate object comprising a number of combined laminate layers and a fiber-reinforced laminate object in the form of the blade of a wind turbine, wherein the blade of the wind turbine comprises a number of combined laminate layers.

Abstract: The invention relates novel NK1 receptor antagonists represented in formula A, wherein R1 and R2 independently are selected from the group consisting of (C1-4)alkyl, (C1-4)haloalkyl, (C1-4)alkoxy, CD3 or halogen; R3 is selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4)haloalkyl and (C1-4)hydroxyalkyl; R4 is selected from the group consisting of phenyl, 5-membered heteroaryl and 6-membered heteroaryl; R5 and R6 are independently selected from the group consisting of hydrogen, (C1-4)alkyl, (C1-4) hydroxyalkyl and (C1-4)haloalkyl and X and Y are independently selected from the group consisting of CH and N. The invention furthermore relates to intermediates for the preparation of said compounds, to their use in therapy, and to pharmaceutical compositions comprising said compounds.

Abstract: The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(?O)OR7 or C1-4 alkyl optionally substituted with hydroxy or NR8R9; R4 is hydrogen or oxo; R5 and R6 are independently hydrogen, hydroxy, NR8R9, C(?O)R7, C(?O)OR7, C(?O)NR8R9, C1-4 alkyl, wherein said C1-4 alkyl is optionally substituted with hydroxy, NR8R9 or a 5- or 6-membered heterocyclic ring, wherein said 5- or 6-membered heterocyclic ring is optionally substituted with C1-4 alkyl or C(?O)R7; or R5 and R6, together with the carbon atom to which they are attached, form ?CH2 or a 5- or 6-membered heterocycloalkyl, wherein said heterocycloalkyl is optionally substituted with C1-4 alkyl; R7 is hydrogen or C1-4 alkyl; R8 and R9 are independently hydrogen or C1-4 alkyl, or R8 and R9, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic ring, or a pharmaceutically accep

Abstract: The present invention relates to a compound according to formula (A) wherein n is 1 or 2; R1 and R2 are independently hydrogen, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, CD3 or halogen; R3 is hydrogen, C(?O)OR7 or C1-4 alkyl optionally substituted with hydroxy or NR8R9; R4 is hydrogen or oxo; R5 and R6 are independently hydrogen, hydroxy, NR8R9, C(?O)R7, C(?O)OR7, C(?O)NR8R9, C1-4 alkyl, wherein said C1-4 alkyl is optionally substituted with hydroxy, NR8R9 or a 5- or 6-membered heterocyclic ring, wherein said 5- or 6-membered heterocyclic ring is optionally substituted with C1-4 alkyl or C(?O)R7; or R5 and R6, together with the carbon atom to which they are attached, form ?CH2 or a 5- or 6-membered heterocycloalkyl, wherein said heterocycloalkyl is optionally substituted with C1-4 alkyl; R7 is hydrogen or C1-4 alkyl; R8 and R9 are independently hydrogen or C1-4 alkyl, or R8 and R9, together with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic ring, or a pharmaceutically accep

Abstract: The invention relates to a method of cutting off laminate layers for use in a fibre-reinforced laminate object comprising a number of combined laminate layers, wherein, along a section of the at least one rim of the laminate layer, a tapering cut is performed through the thickness of the laminate layer, whereby the thickness of the laminate layer is reduced. Since not only the number of laminate layers, but also the thickness of the individual laminate layers are reduced, a laminate layer is accomplished that can be used in a laminate object, by which both the issues of areas rich in resin, air pockets and the risk of delamination are reduced. The invention also relates to a laminate layer for use in a fibre-reinforced laminate object comprising a number of combined laminate layers and a fibre-reinforced laminate object in the form of the blade of a wind turbine, wherein the blade of the wind turbine comprises a number of combined laminate layers.

Abstract: The present invention relates to a compound according to formula (I), wherein X and Y are either C and N or N and C; Z is CH2, CH2—CH2, CH2—NH, or NH; R1 is halogen, or R1 is alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, cycloalkyl, alkoxycarbonyl, aryl, all of which are optionally substituted; R2 is hydrogen, or R2 is alkyl, cycloalkyl, alkoxy, heterocycloalkyl, aryl, heteroaryl, alkoxycarbonyl, aminocarbonyl, amino, all of which are optionally substituted; A is aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl or heterocycloalkenyl, all of which are optionally substituted; and pharmaceutically acceptable salts, hydrates, or solvates hereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments, in particular for the treatment of dermal diseases.

Abstract: The invention relates to a method of cutting off laminate layers for use in a fiber-reinforced laminate object comprising a number of combined laminate layers, wherein, along a section of the at least one rim of the laminate layer, a tapering cut is performed through the thickness of the laminate layer, whereby the thickness of the laminate layer is reduced. Since not only the number of laminate layers, but also the thickness of the individual laminate layers are reduced, a laminate layer is accomplished that can be used in a laminate object, by which both the issues of areas rich in resin, air pockets and the risk of delamination are reduced. The invention also relates to a laminate layer for use in a fiber-reinforced laminate object comprising a number of combined laminate layers and a fiber-reinforced laminate object in the form of the blade of a wind turbine, wherein the blade of the wind turbine comprises a number of combined laminate layers.

Abstract: The present invention concerns a method of producing a lightning diverter for conducting a lightning-induced electrical current, which is to be placed on structures such as wings on wind turbines, aircraft components, radomes and the like with the purpose of lightning protection. The method comprises the steps of making a plurality of holes in a plate of an electrically conductive material, filling said holes at least partly with one or more electrically non-conductive materials, and then finally dividing the plate—preferably into strips. The lightning diverter obtained hereby consists of a layer of electrically non-conductive material with a plurality of isolated segments of electrically conductive material. The invention further relates to a diverter strip with isolated segments of concave shapes being advantageous because of the good connection between the segments and the non-conductive material.

Abstract: The present invention concerns a method of producing a lightning diverter for conducting a lightning-induced electrical current, which is to be placed on structures such as wings on wind turbines, aircraft components, radomes and the like with the purpose of lightning protection. The method comprises the steps of making a plurality of holes in a plate of an electrically conductive material, filling said holes at least partly with one or more electrically non-conductive materials, and then finally dividing the plate—preferably into strips. The lightning diverter obtained hereby consists of a layer of electrically non-conductive material with a plurality of isolated segments of electrically conductive material. The invention further relates to a diverter strip with isolated segments of concave shapes being advantageous because of the good connection between the segments and the non-conductive material.

Abstract: A method of manufacturing a fiber-reinforced blade for a wind energy plant is presented, which blade is configured with at least a blade shell and means for conducting to a lightning current to an earth connection. Novel aspects of the method comprise that the blade is provided with segmented conductor means that are configured for conducting a lightning current outside the blade to the means for conducting to earth; and wherein the conductor means are distributed and secured at the external surface of the blade shell in such a manner that the conductor means are essentially flush with the external surface of the blade shell. When the segmented conductor means are distributed and attached at the external surface of the blade shell, the lightning current will not have to be conducted through the conductor means, but rather they are conducted in a ionised passage in the air above the conductor means.

Abstract: The present invention concerns a method of producing a lightning diverter for conducting a lightning-induced electrical current, which is to be placed on structures such as wings on wind turbines, aircraft components, radomes and the like with the purpose of lightning protection. The method comprises the steps of making a plurality of holes in a plate of an electrically conductive material, filling said holes at least partly with one or more electrically non-conductive materials, and then finally dividing the plate—preferably into strips. The lightning diverter obtained hereby consists of a layer of electrically non-conductive material with a plurality of isolated segments of electrically conductive material. The invention further relates to a diverter strip with isolated segments of concave shapes being advantageous because of the good connection between the segments and the non-conductive material.

Abstract: The present invention relates to a compound according to formula (I), wherein X and Y are either C and N or N and C; Z is CH2, CH2—CH2, CH2—NH, or NH; R1 is halogen, or R1 is alkyl, alkenyl, alkynyl, haloalkyl, alkoxy, cycloalkyl, alkoxycarbonyl, aryl, all of which are optionally substituted; R2 is hydrogen, or R2 is alkyl, cycloalkyl, alkoxy, heterocycloalkyl, aryl, heteroaryl, alkoxycarbonyl, aminocarbonyl, amino, all of which are optionally substituted; A is aryl, cycloalkyl, cycloalkenyl, heteroaryl, heterocycloalkyl or heterocycloalkenyl, all of which are optionally substituted; and pharmaceutically acceptable salts, hydrates, or solvates hereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments, in particular for the treatment of dermal diseases.

Abstract: The present invention concerns a method of producing a lightning diverter for conducting a lightning-induced electrical current, which is to be placed on structures such as wings on wind turbines, aircraft components, radomes and the like with the purpose of lightning protection. The method comprises the steps of making a plurality of holes in a plate of an electrically conductive material, filling said holes at least partly with one or more electrically non-conductive materials, and then finally dividing the plate—preferably into strips. The lightning diverter obtained hereby consists of a layer of electrically non-conductive material with a plurality of isolated segments of electrically conductive material. The invention further relates to a diverter strip with isolated segments of concave shapes being advantageous because of the good connection between the segments and the non-conductive material.

Abstract: The invention relates to a method of cutting off laminate layers for use in a fibre-reinforced laminate object (701) comprising a number of combined laminate layers (703) wherein, along a section of the at least one rim of the laminate layer, a tapering cut is performed through the thickness of the laminate layer, whereby the thickness of the laminate layer is reduced. Since not only the number of laminate layers, but also the thickness of the individual laminate layers are reduced, a laminate layer is accomplished that can be used in a laminate object, by which both the issues of areas rich in resin, air pockets and the risk of delamination are reduced. The invention also relates to a laminate layer for use in a fibre-reinforced laminate object comprising a number of combined laminate layers and a fiber-reinforced laminate object in the form of the blade of a wind turbine, wherein the blade of the wind turbine comprises a number of combined laminate layers.