Abstract: A star-blocked polymeric material based on polyethylene glycol and having a uniform distribution of both hydroxy and amine functional groups throughout the polymeric material is described. The polymeric material, known as HYDRA (hydroxy and amine functionalized resin), is prepared by forming a polyimine compound by reacting an aldehyde and an amine. The polyimine is then reacted with a reducing agent to form a star-blocked polymeric material. HYDRA resins can be used, for example, as solid supports for organic synthesis, for enzymatic assays, for immobilization of biomolecules, for controlled release of drugs, and for chromatographic separations.

Abstract: Described herein is a pentaalkyldisiloxane containing polymeric surfactant prepared by the copolymerization of an alkoxypolyoxyalkylenyl acrylate and an acrylate containing a pentaalkyldisiloxane group. A method for preparing beaded polyethylene glycol-based resins in silicone oil in the presence of a polymeric surfactant containing a pentaalkyldisiloxane group is also described. The average bead size can be controlled by varying the stirring rate, the polymerization temperature, the amount of surfactant, the type of solvent, and the amount of solvent. The surfactant does not interfere with the polymerization and can be removed together with residual silicone oil by a simple washing procedure. The resins can be used, for example, as a support for solid phase organic synthesis, as a chromatographic resin, as a resin for solid phase MAS-NMR spectroscopy, and as a carrier for drug molecules, various reagents, or scavengers.

Abstract: A star-blocked polymeric material based on polyethylene glycol and having a uniform distribution of both hydroxy and amine functional groups throughout the polymeric material is described. The polymeric material, known as HYDRA (hydroxy and amine functionalised resin), is prepared by forming a polyimine compound by reacting an aldehyde and an amine. The polyimine is then reacted with a reducing agent to form a star-blocked polymeric material. HYDRA resins can be used, for example, as solid supports for organic synthesis, for enzymatic assays, for immobilization of biomolecules, for controlled release of drugs, and for chromatographic separations.

Abstract: Described herein is a pentaalkyldisiloxane containing polymeric surfactant prepared by the copolymerization of an alkoxypolyoxyalkylenyl acrylate and an acrylate containing a pentaalkyldisiloxane group. A method for preparing beaded polyethylene glycol-based resins in silicone oil in the presence of a polymeric surfactant containing a pentaalkyldisiloxane group is also described. The average bead size can be controlled by varying the stirring rate, the polymerization temperature, the amount of surfactant, the type of solvent, and the amount of solvent. The surfactant does not interfere with the polymerization and can be removed together with residual silicone oil by a simple washing procedure. The resins can be used, for example, as a support for solid phase organic synthesis, as a chromatographic resin, as a resin for solid phase MAS-NMR spectroscopy, and as a carrier for drug molecules, various reagents, or scavengers.

Abstract: A protected template molecule and a new one-dimensional UniChemo Protection (UCP) organic synthetic method for preparing polyfunctional organic molecules is described. The synthetic method can be used with many kinds of chemical reactions and provides selective access to many functional groups in a template molecule. The method utilizes protection groups that are each composed of building block units that can be removed one by one affording a new protection group one unit shorter or exposing a functional group on the template molecule. The exposed functional group on the template molecule can react with a target group. Different target groups can be introduced into the template molecule by using protection groups containing different numbers of building block units.