Abstract: First and second structures are connected by helical fibers. The orientation between the first and second structures are changed, and by doing so, the positions of the helical fibers are correspondingly changed. The position of change of the helical fibers can be used for a pumping effect, or to change some other fluidic characteristics. One other fluidic characteristics, for example, may use the movement of the helical fibers as a valve.

Abstract: Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involves bypassing diseased trabecular meshwork with the use of a stent implant. The stent implant is inserted into an opening created in the trabecular meshwork by a piercing member that is slidably advanceable through the lumen of the stent implant for supporting the implant insertion. The stent implant is positioned through the trabecular meshwork so that an inlet end of the stent implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.

Abstract: In various embodiments of a method for filling root canal spaces, the root canal spaces are cleaned and irrigated, for example, by any suitable endodontic procedure, and the irrigating liquid is not removed from the canal spaces prior to filling. In some embodiments, a hydrophobic filler material is introduced into the root canal spaces while they are filled with liquid. As the canal spaces are filled, the hydrophobic filler material displaces the liquid and drives it out of the canal spaces, towards the crown of the tooth, where it can be removed. The hydrophobic filler material may comprise magnetically responsive particles having a hydrophobic surface coating that are compacted into the root canal spaces by application of a magnetic force field. In other embodiments, hydrophilic filler material in a flowable phase is introduced into the canal spaces where it partly displaces and partly absorbs the irrigating liquid before solidifying.

Abstract: Described is a method and apparatus for obtaining additional information from an object and a method for surface imaging and three-dimensional imaging. Single lens, single aperture, single sensor system and stereo optic systems are enhanced via selective filtering, use of defocusing information, use of an addressable pattern, image matching, and combinations thereof.

Abstract: Disclosed herein are methods, devices, and other components for synthesizing polymers. In some embodiments, numerous sites can be multiplexed together to allow for effective nucleic acid synthesis.

Abstract: The present invention relates to a system for three-dimensional (3-D) acoustic imaging of a scattering structure using information from a two-dimensional (2-D) image. The system uses a characterized sensor array to emit a signal from the sensor array into an object of interest to generate at least one 2-D representation of the object of interest. The 2-D representation comprises a plurality of x and y coordinate pairs and at least one candidate scattering structure. The candidate scattering structure comprises a shape defined by at least one pair of x and y coordinates. The candidate scattering structure shape is restricted to at least one pair of x and y coordinates. The pair of x and y coordinates of the candidate scattering structure shape are then compared with a first coordinate-dependent response function to assign an x, y, and z position of a scattering structure in 3-D space.

Abstract: A pump installed inside a graft in a body such as the human body to force fluid such as blood through that graft. The pump can be one which operates totally from the outside of the graft, forcing fluid through the graft without extending inside the graft. The pump can be an impedance pump, that operates based on the fluidic mismatches between the graft, and other fluid carrying vessels within the human body.

Abstract: The invention generally relates to a device for assessing dynamic microvascular refill (DMR), a novel measure of microvascular function. Microvascular refill is determined under dynamic conditions by monitoring changes in fingernail reflectance spectra in response to small shear forces applied to the fingernail. A hemodynamic model is described to examine the physiological significance of observed signals. The invention will provide healthcare workers with a simple, user friendly, non-invasive method of rapidly assessing microvascular function that would greatly facilitates the early detection and monitoring of the onset and treatment of vascular diseases.

Abstract: Described is a monolithic in situ forming valve system. The valve system is delivered in an unformed, collapsed configuration that lacks any functional characteristics commonly associated with a valve before. However, once expanded, the system is transformed into a competent valve for use in a wide variety of applications. The valve system includes a superior expandable structure, an inferior expandable structure, and a helical pre-valve component. The helical pre-valve component comprises a first end attached with the superior expandable structure and a second end attached with the inferior expandable structure. The helical pre-valve component is formed such that expansion of the superior expandable structure and the inferior expandable structure causes the helical pre-valve structure to transform into a functional valve held between each of the expandable structures.

Abstract: A medical device for placement of regional anesthesia catheters. The device comprises a hollow shaft needle, a plunger attached to the posterior end of the needle, a housing dimensioned so that plunger can slide inside the housing with friction, a regional anesthesia catheter preloaded inside the needle, a protective cover sheath covering the catheter, and a catheter adaptor attached to posterior end of the sheath and the catheter. The medical device allows a practitioner to quickly and effectively place a regional anesthesia catheter inside an organism without the use of an assistant, and with minimal risk of contaminating the catheter before it enters the organism's body. At the end, the needle is withdrawn inside the housing and disposed.

Abstract: The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored within the substrate, and with at least one end of the carbon nanotubes protruding from the substrate. The protruding nanotube ends may be coated with a drug for delivery of the drug into body tissue. The present invention may be incorporated into an angioplasty catheter balloon or into a patch that is worn on the skin. The carbon nanotubes can be grouped in clusters to effectively form nano-needles which can transfer fluid to or from the subdermal tissue. The nano-needles can be used in conjunction with a sensor to ascertain body fluid information such as pH, glucose level, etc.

Abstract: The present invention relates to a method and apparatus for generating pressure suitable in magnitude for powering micro-sized devices. The present invention typically comprises a gas generation chamber that is equipped with an activation element and filled with a gas-containing liquid. Powering of the activation element causes gas within the liquid to be released. Upon release a series of pressure distribution channels deliver the gas to a wide variety of peripheral microfluidic devices. A series of one-way valves and multi-chambered configurations allow for a wide variety of pressures to be generated from a single pressure generation device. By manipulating the scale of the pressure generation device, lab-on-chip, hand held, and bench top applications are possible and may readily be interfaced to allow a substantial amount of user control of the system.

Abstract: A pump installed inside a graft in a body such as the human body to force fluid such as blood through that graft. The pump can be one which operates totally from the outside of the graft, forcing fluid through the graft without extending inside the graft. The pump can be an impedance pump, that operates based on the fluidic mismatches between the graft, and other fluid carrying vessels within the human body.

Abstract: Apparatus and methods for monitoring a tooth may include sensing acoustic energy propagating from regions (such as a root canal system) in and/or near a tooth. The apparatus and methods may be used with root canal cleaning treatments to determine the efficacy of the treatment and/or to reduce risk of post-treatment complications. An acoustic source (e.g., an acoustic transducer and/or a high-speed liquid jet) may be used to transmit energy into a tooth and/or regions near a tooth. An acoustic receiver may be used to detect acoustic signatures of acoustic events (e.g., acoustic echoes and/or acoustic cavitation) occurring in the tooth. The acoustic signatures may be used, for example, to determine the progress of a root canal cleaning treatment and/or the presence or movement of material toward a periapical region of the tooth. Apparatus and methods for monitoring a tooth may include detecting impact of a first jet on a tooth and actuating a second jet in response to detection of the impact.

Abstract: The present invention relates to a system for three-dimensional (3-D) acoustic imaging of a scattering structure using information from a two-dimensional (2-D) image. The system uses a characterized sensor array to emit a signal from the sensor array into an object of interest to generate at least one 2-D representation of the object of interest. The 2-D representation comprises a plurality of x and y coordinate pairs and at least one candidate scattering structure. The candidate scattering structure comprises a shape defined by at least one pair of x and y coordinates. The candidate scattering structure shape is restricted to at least one pair of x and y coordinates. The pair of x and y coordinates of the candidate scattering structure shape are then compared with a first coordinate-dependent response function to assign an x, y, and z position of a scattering structure in 3-D space.

Abstract: The invention discloses a trabecular stent and methods for treating glaucoma. The stent may incorporate an intraocular pressure sensor comprising a compressible element that is implanted inside an anterior chamber of an eye, wherein at least one external dimension of the element correlates with intraocular pressure. In some embodiments, the sensor may be coupled to the stent. Also disclosed are methods of delivery of the stent and the sensor to the eye.

Abstract: A device, system, and method for measuring the depth of a material layer such as a blood vessel plaque layer is disclosed. A fiber optic bundle housed in a balloon catheter projects a laser dot toward a conical mirror, which reflects the dot perpendicularly onto the surface of the plaque. The laser dot is reflected back from the plaque layer with a substantially Gaussian intensity profile. The conical mirror directs the reflected image back to the fiber optic bundle, which delivers the image to a sensor. The depth of the plaque layer can be determined by comparing the diameter of the image intensity profile to a pre-obtained normalized data set.

Abstract: The invention discloses a trabecular stent and methods for treating glaucoma. The stent may incorporate an intraocular pressure sensor comprising a compressible element that is implanted inside an anterior chamber of an eye, wherein at least one external dimension of the element correlates with intraocular pressure. In some embodiments, the sensor may be coupled to the stent. Also disclosed are methods of delivery of the stent and the sensor to the eye.

Abstract: A trabecular pump is implantable in the eye to reduce intraocular pressure. The pump drains aqueous humor from the anterior chamber into outflow pathways, such as Schlemm's canal. A feedback system includes an intraocular pump and a pressure sensor in communication with the pump, for regulating intraocular pressure.

Abstract: A system and method for improving resolution of a 3-D image by pattern inversion is disclosed. An image of a marker pattern transmitted from the surface of a 3-D object is captured with a sensor and analyzed using a 3-D image analysis method. The respective light and dark areas in the image are then inverted. The inverted image is then analyzed using a 3-D image analysis method, whereby the inversion allows for analysis of a greater portion of the image, resulting in a higher resolution 3-D image than without inversion.