Patents by Inventor Morteza M. Vaghefi

Morteza M. Vaghefi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pre-activated carbonyl linkers for the modification of oligonucleotides
    Patent number: 6320041
    Abstract: The present invention provides a variety of compositions that comprise an activated carboxylic ester moiety on one end of an alkyl tether and a nucleic acid binding moiety on the other end for use as crosslinking reagents in conjugation reactions of nucleotides with solid support matrixes, organic molecules, reporter groups or other biomolecules.
    Type: Grant
    Filed: April 13, 2001
    Date of Patent: November 20, 2001
    Assignee: Trilink Biotechnologies, Inc.
    Inventors: Richard I. Hogrefe, Morteza M. Vaghefi
  • 2'-O-methyl cytidine monomer useful in oligonucleotide synthesis
    Patent number: 5859234
    Abstract: Methods of preparing N.sup.4 -alkanoyl, aroyl and aralkanoyl 2'-O-methylcytidine derivatives are provided. Also provided are cytidine derivatives and nucleoside monomers comprising these cytidine derivatives which are useful in the synthesis of Oligomers, including oligonucleotides and methylphosphonate Oligomers.
    Type: Grant
    Filed: October 8, 1996
    Date of Patent: January 12, 1999
    Assignee: Genta, Incorporated
    Inventor: Morteza M. Vaghefi
  • Method of preparing 2'-O-methyl cytidine monomers useful in oligomer synthesis
    Patent number: 5606049
    Abstract: Methods of preparing N.sup.4 -alkanoyl, aroyl and aralkanoyl 2'-O-methylcytidine derivatives are provided. Also provided are novel cytidine derivatives and nucleoside monomers comprising these cytidine derivatives which are useful in the synthesis of Oligomers, including oligonucleotides and methylphosphonate Oligomers.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: February 25, 1997
    Assignee: Genta Incorporated
    Inventor: Morteza M. Vaghefi