Abstract: The formulation disclosed herein has beneficial properties in enhancing the solubility and permeability (flux) of at least one of vardenafil, sildenafil, and/or related phosphodiesterase inhibitors or other ionizable compounds. In particular, the formulation confers beneficial properties for compounds in crossing the mucosal membrane, leading to an effective plasma drug concentration. In some embodiments, the formulation comprises an organic-aqueous solvent, which may include at least one of an alcohol, a polyether, diethylene glycol monoethyl ether, a medium chain glyceride, one or more saturated polyglycolyzed C8-C10 glyceride, and/or organic salts, or any combination thereof. In some embodiments, the formulation has a pH of about 3.5 to about 8.0. Also disclosed herein is a use for the formulation in administering one or more compound for the treatment of erectile dysfunction or other diseases, wherein the one or more compound is administered transmucosally (intranasally or sublingually).

Abstract: Methods for preparing an herbal powder extract from a polysaccharide-peptide rich mushroom, including Coriolus versicolor (Yunzhi), are disclosed. A more effective, highly pure Yunzhi powder extract, methods of preparing and using the same in ameliorating cancerous cell proliferations and hepatitis and are also disclosed.