Abstract: Disclosed herein are compounds that inhibit cullin-RING E3 ubiquitin ligase 4, a method of inhibiting the catalytic activity of a Cullin-RING E3 Ubiquitin (Ub) Ligase (CRL) in a cell, compositions comprising the inhibitor compounds, a method of treating a tumor, and a method of treating a subject for cancer.

Abstract: The various embodiments of the present invention disclose an apparatus, modular tracking unit and a method for conveyor belt alignment. The apparatus provides alignment sustenance and wide-angle coverage. The apparatus includes a plurality of modular tracking units, a linking mechanism including a connecting rope passing through a link of each of the modular tracking units and a pair of guide rollers. The invention triggers the pair of guided rollers on misalignment of the conveyor belt from original path. The guided roller activates the linking mechanism to move the modular tracking units in tandem for re-aligning the conveyor belt.

Abstract: The various embodiments of the present invention disclose an apparatus, modular tracking unit and a method for conveyor belt alignment. The apparatus provides alignment sustenance and wide-angle coverage. The apparatus includes a plurality of modular tracking units, a linking mechanism including a connecting rope passing through a link of each of the modular tracking units and a pair of guide rollers. The invention triggers the pair of guided rollers on misalignment of the conveyor belt from original path. The guided roller activates the linking mechanism to move the modular tracking units in tandem for re-aligning the conveyor belt.

Abstract: The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.

Abstract: The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.

Abstract: A detachable arm rest for a passenger seat includes a vertical member supported at one end thereof from the floor of a motor vehicle, and is adapted for attachment to the inboard side of the seat near the front edge thereof; a horizontal member extending from the other end of said vertical member, said horizontal member being adapted for connection to the back support portion of said seat, and an extension member attached to the top side of said horizontal member thereby providing a supporting surface for the interior arm.