Patents by Inventor Moses V. Chao

Moses V. Chao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of PDE4 and Methods of Use
    Publication number: 20100216703
    Abstract: The inventors have succeeded in discovering that the p75 neurotrophin receptor (p75NTR) is directly involved in the degradation of cAMP via interaction of its intracellular domain with phosphodiesterase 4A4/5 (PDE4A4/5). Provided herein are methods and compositions for the treatment of conditions of PDE4A4/5 and p75NTR expression (such as pulmonary disease and nerve regeneration) by blocking the interaction of PDE4A4/5 and p75NTR, as well as methods for the screening of agents useful in such applications.
    Type: Application
    Filed: August 14, 2007
    Publication date: August 26, 2010
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NEW YORK UNIVERSITY, UNIVERSITY OF GLASGOW
    Inventors: Katerina Akassoglou, Miles D. Houslay, Moses V. Chao
  • Method for screening molecules that exert a neurotrophic effect through activation of neurotrophin receptors
    Patent number: 7169568
    Abstract: The present invention is directed to a method for screening and identifying molecules that transactivate a neurotrophin receptor and mediate neuronal cell survival in the absence of neurotrophins which uses one or a combination of three different assays. The assays involve detecting the phosphorylation of a neurotrophin receptor, detecting the phosphorylation of phosphotidylinositol 3?-kinase or Akt enzyme, and assessing neuronal cell survival in the absence of neurotrophins.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: January 30, 2007
    Assignee: New York University
    Inventors: Moses V. Chao, Francis S. Lee
  • Molecules of the card-related protein family and uses thereof
    Patent number: 6680167
    Abstract: The invention relates to CARD-3, a mediator of apoptosis. CARD-3 contains a CARD domain and a serine/threonine kinase domain. CARD-3 nucleic acids and polypeptides are useful in mediating apoptosis and in the identification of compounds which modulate apoptosis.
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: January 20, 2004
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: John Bertin, Moses V. Chao
  • Transmembrane protein as a downstream target of neurotrophin and ephrin receptor tyrosine kinases, DNA encoding same and monoclonal antibodies thereto
    Publication number: 20030166056
    Abstract: The present invention relates to an ankyrin repeat-rich membrane spanning (ARMS) polypeptide which is a downstream target of neurotrophin and ephrin receptor tyrosine kinases. This ARMS polypeptide contains 1715 amino acid residues including four transmembrane domains, multiple ankyrin repeats, a sterile &agr; motif domain, and a PDZ-binding motif. Immunofluorescence studies with anti-ARMS antibodies have found ARMS to be localized discreetly to the growth cone of neurons.
    Type: Application
    Filed: December 19, 2001
    Publication date: September 4, 2003
    Applicant: New York University
    Inventors: Moses V. Chao, Haeyoung Kong
  • Method for screening molecules that exert a neurotrophic effect through activation of neurotrophin receptors
    Publication number: 20020110837
    Abstract: The present invention is directed to a method for screening and identifying molecules that transactivate a neurotrophin receptor and mediate neuronal cell survival in the absence of neurotrophins which uses one or a combination of three different assays. The assays involve detecting the phosphorylation of a neurotrophin receptor, detecting the phosphorylation of phosphotidylinositol 3′-kinase or Akt enzyme, and assessing neuronal cell survival in the absence of neurotrophins.
    Type: Application
    Filed: October 19, 2001
    Publication date: August 15, 2002
    Inventors: Moses V. Chao, Francis S. Lee
  • Novel molecules of the card-related protein family and uses thereof
    Publication number: 20020061833
    Abstract: The invention relates to CARD-3, a mediator of apoptosis. CARD-3 contains a CARD domain and a serine/threonine kinase domain. CARD-3 nucleic acids and polypeptides are useful in mediating apoptosis and in the identification of compounds which modulate apoptosis.
    Type: Application
    Filed: December 26, 2000
    Publication date: May 23, 2002
    Inventors: John Bertin, Moses V. Chao