Patents by Inventor Moshe Biton

Moshe Biton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL ATLAS OF THE HEALTHY AND ULCERATIVE COLITIS HUMAN COLON
    Publication number: 20210325387
    Abstract: The present invention provides for a human cell atlas of the colon from healthy and diseased subjects. The atlas was obtained by single sequencing of about 117,000 cells. The present invention discloses novel markers for cell types. Moreover, genes associated with disease are identified in the colon and colon specific cell types. The invention provides for diagnostic assays based on gene markers and cell composition, as well as target cell types that express genes associated with disease. Finally, disclosed are novel cell types and methods of quantitating, detecting and isolating the cell types.
    Type: Application
    Filed: July 17, 2018
    Publication date: October 21, 2021
    Inventors: Alexander K. Shalek, Christopher Smillie, Rebecca H. Herbst, Moshe Biton, Aviv Regev, Jose Ordovas-Montanes, Ramnik Xavier
  • RESPIRATORY AND SWEAT GLAND IONOCYTES
    Publication number: 20210115407
    Abstract: Provided herein are methods and compositions for identifying ionocytes from respiratory epithelial cells, and uses of such cells for treatment of inflammatory lung disease. Also provided herein are methods and compositions for modulating respiratory tract epithelial cell proliferation, differentiation, maintenance, and/or function.
    Type: Application
    Filed: April 12, 2018
    Publication date: April 22, 2021
    Inventors: Jayaraj Rajagopal, Aviv Regev, Moshe Biton, Adam Haber, Daniel Montoro, Orit Rozenblatt-Rosen
  • MODULATION OF EPITHELIAL CELL DIFFERENTIATION, MAINTENANCE AND/OR FUNCTION THROUGH T CELL ACTION, AND MARKERS AND METHODS OF USE THEREOF
    Publication number: 20210040442
    Abstract: An atlas of intestinal epithelial cells, intestinal epithelial stem cells and intestinal immune cells identifies new cell populations, markers, networks, and responses to stimuli. Intestinal epithelial cell sub-types are also found in the trachea. Accordingly, disclosed are methods of modulating epithelial cell differentiation, maintenance and/or function, related methods for the treatment of disease, including IBD and asthma. Also disclosed are methods and kits for identifying cell types, their differentiation, homeostasis and activation.
    Type: Application
    Filed: April 12, 2018
    Publication date: February 11, 2021
    Inventors: Jayaraj Rajagopal, Aviv Regev, Moshe Biton, Adam Haber, Daniel Montoro, Ramnik Xavier
  • MODULATION OF INTESTINAL EPITHELIAL CELL DIFFERENTIATION, MAINTENANCE AND/OR FUNCTION THROUGH T CELL ACTION
    Publication number: 20190263912
    Abstract: An atlas of intestinal epithelial cells, intestinal epithelial stem cells and intestinal immune cells identifies new cell populations, markers, networks, and responses to stimuli. Intestinal T cells drive intestinal epithelial cell differentiation and activity. Accordingly, disclosed are methods of modulating intestinal epithelial cell differentiation, maintenance and/or function, related methods for the treatment of disease, including IBD. Also disclosed are methods and kits for identifying cell types, their differentiation, homeostasis and activation.
    Type: Application
    Filed: November 7, 2017
    Publication date: August 29, 2019
    Inventors: Adam Haber, Moshe Biton, Rebecca H. Herbst, Karthik Shekhar, Christopher Smillie, Orit Rozenblatt-Rosen, Ramnik Xavier, Aviv Regev, Jose Ordovas-Montanes, Alexander K. Shalek, Noga Rogel