Patents by Inventor Moshe Klein
Moshe Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240043893Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets or other compartments, for instance, arising from a cell. In one set of embodiments, particles may be prepared containing oligonucleotides that can be used to determine target nucleic acids, e.g., attached to the surface of the particles. The oligonucleotides may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together or removed from the droplets. Certain embodiments of the invention are generally directed to systems and methods for attaching additional or arbitrary sequences to the nucleic acids within microfluidic droplets or other compartments, e.g.Type: ApplicationFiled: July 14, 2023Publication date: February 8, 2024Applicant: President and Fellows of Harvard CollegeInventors: David A. Weitz, Huidan Zhang, John Heyman, Allon Moshe Klein
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Patent number: 11746367Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. In one aspect, the present invention is generally directed to a method, wherein the method includes providing a plurality of droplets comprising particles, the particles comprising oligonucleotides, and attaching a nucleic acid sequence to the oligonucleotides. Certain embodiments are generally directed to systems and methods for splitting a droplet into two or more droplets. Certain embodiments are generally directed to systems and methods for sorting fluidic droplets in a liquid.Type: GrantFiled: April 15, 2016Date of Patent: September 5, 2023Assignee: President and Fellows of Harvard CollegeInventors: David A. Weitz, Huidan Zhang, John Heyman, Allon Moshe Klein
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Publication number: 20210379555Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.Type: ApplicationFiled: May 18, 2021Publication date: December 9, 2021Applicants: President and Fellows of Harvard College, Vilnius UniversityInventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
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Patent number: 11100551Abstract: Apparatus, article of manufacture and method for designing a jewelry setting that comprise displaying on a display a plurality of components. Each component corresponds to a section of a jewelry setting. A selection of at least one component that corresponds to a first section of the jewelry setting is received. An electronic template of the jewelry setting is generated. The electronic image comprises the at least one selected component. The electronic template is transmitted to a remote device.Type: GrantFiled: January 4, 2019Date of Patent: August 24, 2021Assignee: Electronic Commodities ExchangeInventors: Brian Watkins, Alex Berg, Moshe Klein, Joel Klein, Simon Tam, Christopher Thomas
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Patent number: 11052368Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.Type: GrantFiled: May 29, 2018Date of Patent: July 6, 2021Assignees: Vilnius University, President and Fellows of Harvard CollegeInventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
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Patent number: 10679282Abstract: Methods, systems and apparatus for virtual online jewelry sales in secondary markets.Type: GrantFiled: December 21, 2018Date of Patent: June 9, 2020Assignee: ELECTRONIC COMMODITIES EXCHANGE, L.P.Inventors: Howard Lutnick, Simon Tam, Brian Watkins, Moshe Klein, Joel Klein, Alex Berg
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Patent number: 10650428Abstract: Methods and systems are provided for designing a customized jewelry item via an electronic communications network. Some embodiments may include generating an interactive design tool. The interactive design tool may comprise an electronic template of a customized setting, which may comprise a plurality of sections. A user may select a section of a customized setting and a customizable feature of the selected section. A graphical representation of the customized setting with the customizable feature may be generated and displayed at a graphical user interface of an electronic display device.Type: GrantFiled: June 12, 2017Date of Patent: May 12, 2020Assignee: ELECTRONIC COMMODITIES EXCHANGE, L.P.Inventor: Moshe Klein
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Patent number: 10596541Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.Type: GrantFiled: October 3, 2017Date of Patent: March 24, 2020Assignees: President and Fellows of Harvard College, Vilnius UniversityInventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
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Publication number: 20190213655Abstract: Apparatus, article of manufacture and method for designing a jewelry setting that comprise displaying on a display a plurality of components. Each component corresponds to a section of a jewelry setting. A selection of at least one component that corresponds to a first section of the jewelry setting is received. An electronic template of the jewelry setting is generated. The electronic image comprises the at least one selected component. The electronic template is transmitted to a remote device.Type: ApplicationFiled: January 4, 2019Publication date: July 11, 2019Inventors: Brian Watkins, Alex Berg, Moshe Klein, Joel Klein, Simon Tam, Christopher Thomas
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Publication number: 20190114698Abstract: Methods, systems and apparatus for virtual online jewelry sales in secondary markets.Type: ApplicationFiled: December 21, 2018Publication date: April 18, 2019Inventors: Howard Lutnick, Simon Tam, Brian Watkins, Moshe Klein, Joel Klein, Alex Berg
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Patent number: 10204366Abstract: Apparatus, article of manufacture and method for designing a jewelry setting that comprise displaying on a display a plurality of components. Each component corresponds to a section of a jewelry setting. A selection of at least one component that corresponds to a first section of the jewelry setting is received. An electronic template of the jewelry setting is generated. The electronic image comprises the at least one selected component. The electronic template is transmitted to a remote device.Type: GrantFiled: March 15, 2013Date of Patent: February 12, 2019Assignee: ELECTRONIC COMMODITIES EXCHANGEInventors: Brian Watkins, Alex Berg, Moshe Klein, Joel Klein, Simon Tam, Christopher Thomas
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Patent number: 10176515Abstract: Methods, systems and apparatus for virtual online jewelry sales in secondary markets.Type: GrantFiled: April 1, 2015Date of Patent: January 8, 2019Assignee: ELECTRONIC COMMODITIES EXCHANGE, L.P.Inventors: Howard Lutnick, Simon Tam, Brian Watkins, Moshe Klein, Joel Klein, Alex Berg
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Publication number: 20180304222Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.Type: ApplicationFiled: May 29, 2018Publication date: October 25, 2018Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
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Publication number: 20180182007Abstract: Disclosed herein are an apparatus and method for an on-line preview of an in-store jewelry item. A request from a remote device for a live display of a particular jewelry item is received. In response to the request, live images captured by the microscope while the microscope is aimed at the particular jewelry item are transmitted to the remote device. The microscope is adjusted in response to receiving the commands from the remote device.Type: ApplicationFiled: February 6, 2018Publication date: June 28, 2018Inventors: Brian Watkins, Alex Berg, Josh Marion, Joel Klein, Moshe Klein
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Publication number: 20180087078Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. In one aspect, the present invention is generally directed to a method, wherein the method includes providing a plurality of droplets comprising particles, the particles comprising oligonucleotides, and attaching a nucleic acid sequence to the oligonucleotides. Certain embodiments are generally directed to systems and methods for splitting a droplet into two or more droplets. Certain embodiments are generally directed to systems and methods for sorting fluidic droplets in a liquid.Type: ApplicationFiled: April 15, 2016Publication date: March 29, 2018Applicant: President and Fellows of Harvard CollegeInventors: David A. Weitz, Huidan Zhang, Hohn Heyman, Allon Moshe Klein
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Publication number: 20180071705Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.Type: ApplicationFiled: October 3, 2017Publication date: March 15, 2018Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
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Publication number: 20170278165Abstract: Methods and systems are provided for designing a customized jewelry item via an electronic communications network. Some embodiments may include generating an interactive design tool. The interactive design tool may comprise an electronic template of a customized setting, which may comprise a plurality of sections. A user may select a section of a customized setting and a customizable feature of the selected section. A graphical representation of the customized setting with the customizable feature may be generated and displayed at a graphical user interface of an electronic display device.Type: ApplicationFiled: June 12, 2017Publication date: September 28, 2017Inventor: Moshe Klein
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Patent number: 9679324Abstract: Methods and systems for designing a customized jewelry item on-line. Some embodiments include generating an interactive design tool. The interactive design tool comprises an electronic template of the customized setting and the customized setting comprises a plurality of sections. User-input data is received, in which the user-input data comprises selection of a section of the customized setting; and a selection of at least one customizable feature of the selected section. A graphical representation of the customized setting is generated, in which the customized setting comprises the at least one customizable feature. The graphical representation of the customized setting is displayed on a display.Type: GrantFiled: March 14, 2013Date of Patent: June 13, 2017Assignee: ELECTRONIC COMMODITIES EXCHANGE, L.P.Inventor: Moshe Klein
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Publication number: 20160098090Abstract: A computerized kinetic control system comprising: a kinetic sensor; a display device; and a hardware processor configured to: (a) display, using said display device, a GUI (Graphic User Interface) menu comprising at least two options being disposed away from a center of said display device and at different polar angles relative to the center of said display device, (b) detect, using said kinetic sensor, motion of a limb of a user, and (c) select a first option of the at least two options, wherein the selecting is based on a correspondence between a direction of the motion detected and a polar angle of the first option relative to the center of the display device.Type: ApplicationFiled: April 17, 2014Publication date: April 7, 2016Inventors: David Moshe KLEIN, Eytan SABARI MAJAR
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Publication number: 20150298091Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.Type: ApplicationFiled: June 9, 2015Publication date: October 22, 2015Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner