Patents by Inventor Moshe Klein

Moshe Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240043893
    Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets or other compartments, for instance, arising from a cell. In one set of embodiments, particles may be prepared containing oligonucleotides that can be used to determine target nucleic acids, e.g., attached to the surface of the particles. The oligonucleotides may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together or removed from the droplets. Certain embodiments of the invention are generally directed to systems and methods for attaching additional or arbitrary sequences to the nucleic acids within microfluidic droplets or other compartments, e.g.
    Type: Application
    Filed: July 14, 2023
    Publication date: February 8, 2024
    Applicant: President and Fellows of Harvard College
    Inventors: David A. Weitz, Huidan Zhang, John Heyman, Allon Moshe Klein
  • Patent number: 11746367
    Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. In one aspect, the present invention is generally directed to a method, wherein the method includes providing a plurality of droplets comprising particles, the particles comprising oligonucleotides, and attaching a nucleic acid sequence to the oligonucleotides. Certain embodiments are generally directed to systems and methods for splitting a droplet into two or more droplets. Certain embodiments are generally directed to systems and methods for sorting fluidic droplets in a liquid.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: September 5, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Weitz, Huidan Zhang, John Heyman, Allon Moshe Klein
  • Publication number: 20210379555
    Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.
    Type: Application
    Filed: May 18, 2021
    Publication date: December 9, 2021
    Applicants: President and Fellows of Harvard College, Vilnius University
    Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
  • Patent number: 11100551
    Abstract: Apparatus, article of manufacture and method for designing a jewelry setting that comprise displaying on a display a plurality of components. Each component corresponds to a section of a jewelry setting. A selection of at least one component that corresponds to a first section of the jewelry setting is received. An electronic template of the jewelry setting is generated. The electronic image comprises the at least one selected component. The electronic template is transmitted to a remote device.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: August 24, 2021
    Assignee: Electronic Commodities Exchange
    Inventors: Brian Watkins, Alex Berg, Moshe Klein, Joel Klein, Simon Tam, Christopher Thomas
  • Patent number: 11052368
    Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: July 6, 2021
    Assignees: Vilnius University, President and Fellows of Harvard College
    Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
  • Patent number: 10679282
    Abstract: Methods, systems and apparatus for virtual online jewelry sales in secondary markets.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: June 9, 2020
    Assignee: ELECTRONIC COMMODITIES EXCHANGE, L.P.
    Inventors: Howard Lutnick, Simon Tam, Brian Watkins, Moshe Klein, Joel Klein, Alex Berg
  • Patent number: 10650428
    Abstract: Methods and systems are provided for designing a customized jewelry item via an electronic communications network. Some embodiments may include generating an interactive design tool. The interactive design tool may comprise an electronic template of a customized setting, which may comprise a plurality of sections. A user may select a section of a customized setting and a customizable feature of the selected section. A graphical representation of the customized setting with the customizable feature may be generated and displayed at a graphical user interface of an electronic display device.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: May 12, 2020
    Assignee: ELECTRONIC COMMODITIES EXCHANGE, L.P.
    Inventor: Moshe Klein
  • Patent number: 10596541
    Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: March 24, 2020
    Assignees: President and Fellows of Harvard College, Vilnius University
    Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
  • Publication number: 20190213655
    Abstract: Apparatus, article of manufacture and method for designing a jewelry setting that comprise displaying on a display a plurality of components. Each component corresponds to a section of a jewelry setting. A selection of at least one component that corresponds to a first section of the jewelry setting is received. An electronic template of the jewelry setting is generated. The electronic image comprises the at least one selected component. The electronic template is transmitted to a remote device.
    Type: Application
    Filed: January 4, 2019
    Publication date: July 11, 2019
    Inventors: Brian Watkins, Alex Berg, Moshe Klein, Joel Klein, Simon Tam, Christopher Thomas
  • Publication number: 20190114698
    Abstract: Methods, systems and apparatus for virtual online jewelry sales in secondary markets.
    Type: Application
    Filed: December 21, 2018
    Publication date: April 18, 2019
    Inventors: Howard Lutnick, Simon Tam, Brian Watkins, Moshe Klein, Joel Klein, Alex Berg
  • Patent number: 10204366
    Abstract: Apparatus, article of manufacture and method for designing a jewelry setting that comprise displaying on a display a plurality of components. Each component corresponds to a section of a jewelry setting. A selection of at least one component that corresponds to a first section of the jewelry setting is received. An electronic template of the jewelry setting is generated. The electronic image comprises the at least one selected component. The electronic template is transmitted to a remote device.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 12, 2019
    Assignee: ELECTRONIC COMMODITIES EXCHANGE
    Inventors: Brian Watkins, Alex Berg, Moshe Klein, Joel Klein, Simon Tam, Christopher Thomas
  • Patent number: 10176515
    Abstract: Methods, systems and apparatus for virtual online jewelry sales in secondary markets.
    Type: Grant
    Filed: April 1, 2015
    Date of Patent: January 8, 2019
    Assignee: ELECTRONIC COMMODITIES EXCHANGE, L.P.
    Inventors: Howard Lutnick, Simon Tam, Brian Watkins, Moshe Klein, Joel Klein, Alex Berg
  • Publication number: 20180304222
    Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.
    Type: Application
    Filed: May 29, 2018
    Publication date: October 25, 2018
    Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
  • Publication number: 20180182007
    Abstract: Disclosed herein are an apparatus and method for an on-line preview of an in-store jewelry item. A request from a remote device for a live display of a particular jewelry item is received. In response to the request, live images captured by the microscope while the microscope is aimed at the particular jewelry item are transmitted to the remote device. The microscope is adjusted in response to receiving the commands from the remote device.
    Type: Application
    Filed: February 6, 2018
    Publication date: June 28, 2018
    Inventors: Brian Watkins, Alex Berg, Josh Marion, Joel Klein, Moshe Klein
  • Publication number: 20180087078
    Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. In one aspect, the present invention is generally directed to a method, wherein the method includes providing a plurality of droplets comprising particles, the particles comprising oligonucleotides, and attaching a nucleic acid sequence to the oligonucleotides. Certain embodiments are generally directed to systems and methods for splitting a droplet into two or more droplets. Certain embodiments are generally directed to systems and methods for sorting fluidic droplets in a liquid.
    Type: Application
    Filed: April 15, 2016
    Publication date: March 29, 2018
    Applicant: President and Fellows of Harvard College
    Inventors: David A. Weitz, Huidan Zhang, Hohn Heyman, Allon Moshe Klein
  • Publication number: 20180071705
    Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.
    Type: Application
    Filed: October 3, 2017
    Publication date: March 15, 2018
    Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
  • Publication number: 20170278165
    Abstract: Methods and systems are provided for designing a customized jewelry item via an electronic communications network. Some embodiments may include generating an interactive design tool. The interactive design tool may comprise an electronic template of a customized setting, which may comprise a plurality of sections. A user may select a section of a customized setting and a customizable feature of the selected section. A graphical representation of the customized setting with the customizable feature may be generated and displayed at a graphical user interface of an electronic display device.
    Type: Application
    Filed: June 12, 2017
    Publication date: September 28, 2017
    Inventor: Moshe Klein
  • Patent number: 9679324
    Abstract: Methods and systems for designing a customized jewelry item on-line. Some embodiments include generating an interactive design tool. The interactive design tool comprises an electronic template of the customized setting and the customized setting comprises a plurality of sections. User-input data is received, in which the user-input data comprises selection of a section of the customized setting; and a selection of at least one customizable feature of the selected section. A graphical representation of the customized setting is generated, in which the customized setting comprises the at least one customizable feature. The graphical representation of the customized setting is displayed on a display.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: June 13, 2017
    Assignee: ELECTRONIC COMMODITIES EXCHANGE, L.P.
    Inventor: Moshe Klein
  • Publication number: 20160098090
    Abstract: A computerized kinetic control system comprising: a kinetic sensor; a display device; and a hardware processor configured to: (a) display, using said display device, a GUI (Graphic User Interface) menu comprising at least two options being disposed away from a center of said display device and at different polar angles relative to the center of said display device, (b) detect, using said kinetic sensor, motion of a limb of a user, and (c) select a first option of the at least two options, wherein the selecting is based on a correspondence between a direction of the motion detected and a polar angle of the first option relative to the center of the display device.
    Type: Application
    Filed: April 17, 2014
    Publication date: April 7, 2016
    Inventors: David Moshe KLEIN, Eytan SABARI MAJAR
  • Publication number: 20150298091
    Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.
    Type: Application
    Filed: June 9, 2015
    Publication date: October 22, 2015
    Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner