Abstract: Methods of ex-vivo expansion of endodermally-derived and non-endodermally-derived progenitor and stem cells, expanded populations of renewable progenitor and stem cells and to their uses in therapeutic applications such as the production of endocrine hormones and the prevention and treatment of liver and pancreatic disease.

Abstract: Thiram (tetramethyliuram disulfide) is shown to inhibit angiogenesis and/or inflammation and to be useful in the treatment of angiogenesis-dependent disorders, including neoplasms, and in the inhibition, treatment and allevation of inflammation associated with several disorders and diseases, such as rheumatoid arthritis. Thiram is further useful for prevention of cell hyperproliferation and formation of clots along or around medical devices.

Abstract: Amyloid precursor protein and non-glycosylated peptides derived therefrom especially from the A&bgr; domain of amyloid precursor protein are useful in prevention or treatment of cancer, and for immunostimulation in individuals with compromised immune systems. A peptide comprising residues 1-42 of the amyloid precursor protein, as well as smaller fragments and analogs of this peptide, which demonstrate the anti-cancer activity, are disclosed. A peptide comprising residues 1-16 of the amyloid precursor protein is one currently preferred active fragment. Pharmaceutical compositions comprising these peptides, and methods of using them to prevent or inhibit tumor growth and metastases are disclosed. Methods of gene therapy using APP or APP-derived peptides are also disclosed for treatment of cancer and for immunostimulation.

Abstract: Disulfiram (tetraethylthiuram disulfide) is shown to inhibit angiogenesis and to be useful in the treatment of angiogenesis-dependent disorders, including neoplasms, and to prevent cell hyperproliferation and formation of clots along or around medical devices.

Abstract: The turbidity of a fluid is reduced by adding a treatment solution containing a flocculation agent to said fluid. The treatment solution has a density different from that of the fluid. It is added at selected locations in the fluid such that the difference in densities will cause the treatment solution to be uniformly distributed throughout the fluid to be treated thereby causing flocs to be uniformly distributed throughout the fluid. In this way, a fluid can be treated in situ, rather than transported to a separate location, and mechanically mixed with a flocculation agent. This technique has particular application in the preparation and maintenance of solar ponds.

Abstract: The turbidity of a fluid is reduced by adding a treatment solution containing a flocculation agent to said fluid. The treatment solution has a density different from that of the fluid. It is added at selected locations in the fluid such that the difference in densities will cause the treatment solution to be uniformly distributed throughout the fluid to be treated thereby causing flocs to be uniformly distributed throughout the fluid. In this way, a fluid can be treated in situ, rather than transported to a separate location, and mechanically mixed with a flocculation agent. This technique has particular application in the preparation and maintenance of solar ponds.

Abstract: Dusting of a solar pond having an upper wind-mixed layer is controlled by providing a vertically oriented drain on a downwind side of the pond. The drain has an upper, open, free-end spaced above the level of the surface of the pond in the absence of wind. When wind blows across the pond, surface water piles-up at the downwind side of the pond creating a hydraulic head relative to the open free end of the drain with the result that surface water and debris floating thereon are drawn toward and into the drain.