Patents by Inventor Mostafa A. HAMED
Mostafa A. HAMED has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11883387Abstract: The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.Type: GrantFiled: July 3, 2019Date of Patent: January 30, 2024Assignee: Helmholtz-Zentrum Für Infektionsforschung GmbHInventors: Ahmed S. A. Ahmed, Martin Empting, Mostafa Hamed, Rolf W. Hartmann, Jörg Haupenthal, Thomas Hesterkamp, Ahmed A. M. Kamal, Christine K. Maurer, Teresa Röhrig, Christian Schütz, Samir Yahiaoui, Michael Zender
-
Publication number: 20230286942Abstract: The present invention relates to a compounds according to general formula (I), which acts as an inverse agonist of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS), sometimes also referred to as MvfR); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonasaeruginosa or Burkholderia infection.Type: ApplicationFiled: December 30, 2020Publication date: September 14, 2023Inventors: Christian Schütz, Martin Empting, Ahmed S. Ahmed, Mostafa Hamed, Rolf W. Hartmann, Teresa Röhrig, Andreas M. Kany, Anna K. Hirsch
-
Publication number: 20230106506Abstract: The present invention relates to a compound according to general formula (I), which acts as an inverse agonist of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS), sometimes also referred to as MvfR); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.Type: ApplicationFiled: December 30, 2020Publication date: April 6, 2023Inventors: Mostafa Hamed, Ahmed S. Ahmed, Martin Empting, Christian Schütz, Rolf W. Hartmann, Teresa Röhrig, Andreas M. Kany, Anna K. Hirsch
-
Publication number: 20220257569Abstract: The present application pertains to methods of using indole-oxadiazole compounds of Formula I to modulate cannabinoid receptor activity: I In particular diseases, disorders or conditions that benefit from modulating cannabinoid receptor activity, such as non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), schizophrenia, bipolar disorder, psychosis, metabolic syndrome, type-2 diabetes, dyslipidaemia, obesity, eating disorders, cardiovascular diseases and disorders, and other conditions as described herein, may be treated. Also included in the present application are certain novel compounds of Formula Ia and pharmaceutical compositions comprising these compounds.Type: ApplicationFiled: September 12, 2019Publication date: August 18, 2022Applicants: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEENInventors: Iain Robert GREIG, Ruth ROSS, Amy RAMSEY, Catherine MIELNIK, Laurent Alain Claude TREMBLEAU, Mostafa Hamed ABDELRAHMAN
-
Patent number: 11225503Abstract: The present invention provides cystobactamides of formula (I): R1—Ar1-L1-Ar2-L2-Ar3-L3-Ar4-L4-Ar5—R2 and the use thereof for the treatment or prophylaxis of bacterial infections.Type: GrantFiled: June 10, 2020Date of Patent: January 18, 2022Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBHInventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Huettel
-
Publication number: 20210353606Abstract: The present invention relates to a compound according to general formula (I), which acts as an inhibitor of PqsR (the currently only known receptor for the Pseudomonas Quinolone Signal (PQS)); to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to uses of said compound(s), including the use as a medicament, e.g. the use in the treatment or prophylaxis of a bacterial infection, especially a Pseudomonas aeruginosa or Burkholderia infection.Type: ApplicationFiled: July 3, 2019Publication date: November 18, 2021Inventors: Ahmed S.A. Ahmed, Martin Empting, Mostafa Hamed, Rolf W. Hartmann, Jörg Haupenthal, Thomas Hesterkamp, Ahmed A.M. Kamal, Christine K. Maurer, Teresa Röhrig, Christian Schütz, Samir Yahiaoui, Michael Zender
-
Publication number: 20200331964Abstract: The present invention provides cystobactamides of formula (I): R1—Ar1-L1-Ar2-L2-Ar3-L3-Ar4-L4-Ar5—R2 and the use thereof for the treatment or prophylaxis of bacterial infections.Type: ApplicationFiled: June 10, 2020Publication date: October 22, 2020Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Huettel
-
Patent number: 10793600Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.Type: GrantFiled: July 23, 2018Date of Patent: October 6, 2020Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBHInventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel
-
Patent number: 10519099Abstract: The present invention provides a method for the treatment or prophylaxis of bacterial infections by administering to a subject in need thereof an effective amount of a compound of formula.Type: GrantFiled: November 26, 2015Date of Patent: December 31, 2019Assignee: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBHInventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel
-
Patent number: 10427378Abstract: A stacked composite material and a method of preparation, wherein the stacked composite materials comprises of glass fiber layers sandwiched between nanocomposite layers. The nanocomposite layers comprise a nanofiller dispersed in a cured epoxy matrix, wherein the nanofiller is at least one of silicon carbide nanoparticles or aluminum oxide nanoparticles. Adjacent and noncontiguous glass fiber layers are oriented in a unidirectional orientation or a quasi-isotropic orientation.Type: GrantFiled: May 5, 2016Date of Patent: October 1, 2019Assignee: King Abdulaziz UniversityInventors: Saad M. Aldousari, Hassan S. Hedia, Usama A. Khashaba, Mostafa A. Hamed
-
Patent number: 10427382Abstract: A stacked composite material having at least one glass fiber layer, at least two nanocomposite layers comprising multi walled carbon nanotubes dispersed in an epoxy matrix. Each glass fiber layer is sandwiched between two nanocomposite layers and the glass fiber layers are oriented in a unidirectional or a quasi-isotropic orientation with respect to adjacent and non-contiguous glass fiber layers in the stacked composite material. A method of preparing a stacked composite material comprising applying a nanocomposite layer onto a mold, overlaying a glass fiber layer on top of the nanocomposite layer, rolling an aluminum roller over the glass fiber layer, repeating the applying, overlaying, and rolling to form a stacked composite material.Type: GrantFiled: June 29, 2016Date of Patent: October 1, 2019Assignee: King Abdulaziz UniversityInventors: Saad M. Aldousari, Usama A. Khashaba, Mostafa A. Hamed, Hassan S. Hedia
-
Publication number: 20190185514Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections: R1—Ar1-L1-Ar2-L2-Ar3-L3-Ar4-L4-Ar5—R2??(I):Type: ApplicationFiled: July 23, 2018Publication date: June 20, 2019Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf W. Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel
-
Publication number: 20170327458Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections.Type: ApplicationFiled: November 26, 2015Publication date: November 16, 2017Applicant: HELMHOLTZ-ZENTRUM FÜR INFEKTIONSFORSCHUNG GMBHInventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf Hartmann, Mostafa Hamed, Walid A. M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning, Stephan Hüttel
-
Publication number: 20170120566Abstract: A stacked composite material and a method of preparation, wherein the stacked composite materials comprises of glass fiber layers sandwiched between nanocomposite layers. The nanocomposite layers comprise a nanofiller dispersed in a cured epoxy matrix, wherein the nanofiller is at least one of silicon carbide nanoparticles or aluminum oxide nanoparticles. Adjacent and noncontiguous glass fiber layers are oriented in a unidirectional orientation or a quasi-isotropic orientation.Type: ApplicationFiled: May 5, 2016Publication date: May 4, 2017Applicant: King Abdulaziz UniversityInventors: Saad M. ALDOUSARI, Hassan S. HEDIA, Usama A. KHASHABA, Mostafa A. HAMED
-
Publication number: 20170120563Abstract: A stacked composite material having at least one glass fiber layer, at least two nanocomposite layers comprising multi walled carbon nanotubes dispersed in an epoxy matrix. Each glass fiber layer is sandwiched between two nanocomposite layers and the glass fiber layers are oriented in a unidirectional or a quasi-isotropic orientation with respect to adjacent and non-contiguous glass fiber layers in the stacked composite material. A method of preparing a stacked composite material comprising applying a nanocomposite layer onto a mold, overlaying a glass fiber layer on top of the nanocomposite layer, rolling an aluminum roller over the glass fiber layer, repeating the applying, overlaying, and rolling to form a stacked composite material.Type: ApplicationFiled: June 29, 2016Publication date: May 4, 2017Applicant: King Abdulaziz UniversityInventors: Saad M. ALDOUSARI, Usama A. KHASHABA, Mostafa A. HAMED, Hassan S. HEDIA
-
Publication number: 20160145304Abstract: The present invention provides cystobactamides of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections:Type: ApplicationFiled: July 14, 2014Publication date: May 26, 2016Inventors: Sascha Baumann, Jennifer Herrmann, Kathrin Mohr, Heinrich Steinmetz, Klaus Gerth, Ritesh Raju, Rolf Müller, Rolf Hartmann, Mostafa Hamed, Walid A.M. Elgaher, Maria Moreno, Franziska Gille, Liang Liang Wang, Andreas Kirschning
-
Publication number: 20140197022Abstract: The solar-powered humidification-dehumidification desalination system includes a supply of saline/brackish water passing through a dehumidifier/condenser. The saline/brackish water is preheated in the dehumidifier/condenser due to the condensation process. A plurality of humidifying stages includes respective humidifiers and respective solar collectors. The solar collectors heat air, and the heated air passes through respective humidifiers to evaporate the preheated saline/brackish water, separating pure water from the brine. The humid air is reheated and recirculated through the humidifying stages and the dehumidifier, and the desalinated water from the dehumidifier via condensation is collected to and processed. The system recirculates the brine successively from each humidifier to the next for more efficient evaporation and less energy consumption.Type: ApplicationFiled: January 15, 2013Publication date: July 17, 2014Applicants: KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY, KING FAHD UNIVERSITY OF PETROLEUM AND MINERALSInventors: MOHAMED ABDELKARIM ANTAR, MOSTAFA HAMED ELSHARQAWY
-
Patent number: 8778065Abstract: In a bubble-column vapor mixture condenser, a fluid source supplies a carrier-gas stream including a condensable fluid in vapor phase. The condensable fluid in liquid form is contained as a bath in a chamber in each stage of the condenser, and the carrier gas is bubbled through the bath to condense the condensable fluid into the bath. Energy from condensation is recovered to a coolant in a conduit that passes through the liquid in the stages of the condenser. The bubble-column vapor mixture condenser can be used, e.g., in a humidification-dehumidification system for purifying a liquid, such as water.Type: GrantFiled: August 26, 2013Date of Patent: July 15, 2014Assignees: Massachusetts Institute of Technology, King Fahd University of Petroleum & MineralsInventors: Prakash Narayan Govindan, Gregory P. Thiel, Ronan K. McGovern, John H. Lienhard, Mostafa Hamed Elsharqawy
-
Publication number: 20130341810Abstract: In a bubble-column vapor mixture condenser, a fluid source supplies a carrier-gas stream including a condensable fluid in vapor phase. The condensable fluid in liquid form is contained as a bath in a chamber in each stage of the condenser, and the carrier gas is bubbled through the bath to condense the condensable fluid into the bath. Energy from condensation is recovered to a coolant in a conduit that passes through the liquid in the stages of the condenser. The bubble-column vapor mixture condenser can be used, e.g., in a humidification-dehumidification system for purifying a liquid, such as water.Type: ApplicationFiled: August 26, 2013Publication date: December 26, 2013Applicants: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Prakash Narayan Govindan, Gregory P. Thiel, Ronan K. McGovern, John H. Lienhard, Mostafa Hamed Elsharqawy
-
Patent number: 7853045Abstract: A novel database and method of classifying and searchably retrieving measurement data derived from a plurality of rock core and plug sample images that are analyzed to define their principal geostatistical attributes and characteristics, with the resulting analytical data being retrievably stored in a database, the method including calculating spatial variability of images, such as CT scan images, porosity images and other types of available images, quantifying the main image characteristics utilizing multi-azimuth variograms and simplified pattern recognition based on the histogram and variography analysis to thereby provide a means to correlate data from various geographical regions or fields by analyzing data which has the same variographic parameters.Type: GrantFiled: October 31, 2007Date of Patent: December 14, 2010Assignee: Saudi Arabian Oil CompanyInventors: Mustafa Touati, Shameem Siddiqui, Taha Mostafa Hamed Okasha