Patents by Inventor Motasim Sirhan
Motasim Sirhan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240033475Abstract: An aspiration catheter includes a catheter body having a proximal end, a distal end, and an aspiration lumen therebetween. A distal segment comprising an expandable distal tip of the aspiration catheter comprises a membrane and an expandable supporting structure, such as a scaffold, configured to radially expand the expandable distal tip. The expandable supporting structure may include supporting elements and other features which increase resistance to collapse of the expandable membrane under vacuum or negative pressure applied to aspirate clot through the aspiration lumen in the expanded configuration.Type: ApplicationFiled: October 6, 2023Publication date: February 1, 2024Applicant: Elixir Medical CorporationInventors: Motasim Sirhan, Benjamyn Serna, Kim Nguyen, John Yan, Matthew Tyler Surber
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Publication number: 20230293540Abstract: Devices, formulations, compositions, and methods are provided for inhibiting an inflammatory ophthalmic disease or eye condition in a patient. A therapeutic composition comprising a direct factor Xa inhibitor and/or a direct factor II inhibitor is provided. A therapeutically effective dose of the therapeutic composition is delivered to a site of the inflammatory ophthalmic disease or condition in the patient’s eye(s). The therapeutic composition may be formulated for delivery to the patient by via injection, an implant, an eye drop, an emulsion, a suspension, an ointment, a nanomicelle, a nanoparticle, a nanosuspension, a liposome, an in-situ gel, a contact lens, or a microneedle or the like. The therapeutic composition may include one or more additional therapeutically active substances and/or one or more additional pharmaceutical agents.Type: ApplicationFiled: March 6, 2023Publication date: September 21, 2023Applicant: Elixir Medical CorporationInventors: John Yan, Xiaoxia Zheng, Vinayak D. Bhat, Motasim Sirhan, Margaret Wong, Blaine Bueche
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Publication number: 20230240868Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.Type: ApplicationFiled: March 21, 2023Publication date: August 3, 2023Inventors: Motasim Sirhan, John Yan, Vinayak Bhat, Joseph Paraschac, Brett Cryer, Benjamyn Serna
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Publication number: 20230201014Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.Type: ApplicationFiled: March 3, 2023Publication date: June 29, 2023Applicant: Elixir Medical CorporationInventors: Motasim Sirhan, John Yan, Vinayak Bhat, Joseph Paraschac, Brett Cryer, Benjamyn Serna
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Publication number: 20230190499Abstract: Devices, systems, and methods are provided including a structure having one or more surfaces configured for internal use within a patient's body and one or more therapeutic compositions comprising one or more active substances including a direct factor Xa inhibitor, and a direct factor IIa inhibitor disposed in or on the structure. The structure is configured to be positioned adjacent an injury site in the patient's body. The one or more active substances optionally include an anti-proliferative agent. The therapeutic composition is formulated to release the one or more active substances to the injury site to provide one or more of inhibit clot formation, promote clot dissolution, inhibit or dissolute inflammation, inhibit vessel injury, increase time before clotting, and/or inhibit cell proliferation.Type: ApplicationFiled: February 6, 2023Publication date: June 22, 2023Applicant: Elixir Medical CorporationInventors: Motasim Sirhan, Xiaoxia Zheng, Vinayak D. Bhat, John Yan
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Publication number: 20230165874Abstract: Devices, compositions, and methods are provided for inhibiting an inflammatory, fibrotic, and/or clot formation for pulmonary disease or condition in a patient. A therapeutic composition comprising a direct factor Xa inhibitor and/or a direct factor IIa inhibitor is provided. A therapeutically effective dose of the therapeutic composition is delivered to a site of the inflammatory, fibrotic, and/or clot formation pulmonary disease or condition in the patient's lung(s). The therapeutic composition may be formulated for delivery to the patient by inhalation, ventilation, instillation, ultrasound, vibration, injection, or the like. The therapeutic composition may include one or more additional therapeutically active substances and/or one or more additional pharmaceutical agents.Type: ApplicationFiled: January 27, 2023Publication date: June 1, 2023Applicant: Elixir Medical CorporationInventors: John Yan, Xiaoxia Zheng, Vinayak D. Bhat, Motasim Sirhan, Blaine Bueche
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Patent number: 11654036Abstract: Devices, systems, and methods are provided including a structure having one or more surfaces configured for internal use within a patient's body and one or more therapeutic compositions comprising one or more active substances including a direct factor Xa inhibitor, and a direct factor IIa inhibitor disposed in or on the structure. The structure is configured to be positioned adjacent an injury site in the patient's body. The one or more active substances optionally include an anti-proliferative agent. The therapeutic composition is formulated to release the one or more active substances to the injury site to provide one or more of inhibit clot formation, promote clot dissolution, inhibit or dissolute inflammation, inhibit vessel injury, increase time before clotting, and/or inhibit cell proliferation.Type: GrantFiled: August 13, 2021Date of Patent: May 23, 2023Assignee: Elixir Medical CorporationInventors: Motasim Sirhan, Xiaoxia Zheng, Vinayak D. Bhat, John Yan
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Publication number: 20230149035Abstract: Clot aspiration systems intended for removing clot from a blood vessel include an aspiration assembly which will have two or more of the following components: an aspiration catheter, an inner catheter, an intermediate catheter, and an outer catheter, the latter typically being a guiding or other sheath. A transition structure is coupled to a distal end of the aspiration assembly to cover or fill an open distal end of one or more of the components of the aspiration assembly. The transition structure may be configured to facilitate introduction of the aspiration catheter into the patient's vasculature and/or advancement of the aspiration catheter through the vasculature to a target site, such as a cerebral target site which may be occluded with clot, thrombus, or other occlusive material.Type: ApplicationFiled: January 19, 2023Publication date: May 18, 2023Applicant: Elixir Medical CorporationInventors: Motasim Sirhan, Vinayak Bhat, Benjamyn Serna, Brett Cryer, Kim Nguyen, John Yan
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Patent number: 11622872Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.Type: GrantFiled: February 10, 2020Date of Patent: April 11, 2023Assignee: Elixir Medical CorporationInventors: Motasim Sirhan, John Yan, Vinayak Bhat, Joseph Paraschac, Brett Cryer, Benjamyn Serna
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Publication number: 20220370097Abstract: A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaptation of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.Type: ApplicationFiled: January 4, 2022Publication date: November 24, 2022Applicant: Elixir Medical CorporationInventors: MOTASIM SIRHAN, JOHN YAN, VINAYAK BHAT, JOSEPH PARASCHAC, BENJAMYN SERNA
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Publication number: 20220338889Abstract: Balloon catheters, sleeves, cages, and endoluminal prostheses are provided with stress-applying and spacing features coupled to expandable surfaces thereof. The stress-applying features may have blunt and/or rounded contact regions which contact tissue or calcified regions in the vasculature. The contact regions dent or fracture occlusive material on the wall of a vascular lumen and/or patient valve leaflets when expanded. The spacing features permit blood, drug, and contrast perfusion past structures expanded in the vasculature, particularly balloon catheters.Type: ApplicationFiled: July 12, 2022Publication date: October 27, 2022Applicant: Elixir Medical CorporationInventors: Motasim Sirhan, Benjamyn Serna, Bozena Treadwell, John Yan
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Publication number: 20220280318Abstract: A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.Type: ApplicationFiled: September 16, 2021Publication date: September 8, 2022Applicant: Elixir Medical CorporationInventors: Motasim Sirhan, Vinayak Bhat, Joseph Paraschac, Benjamyn Serna, John Yan
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Publication number: 20220183843Abstract: A catheter system for delivering an anchor to a valve annulus in a heart valve includes a locating catheter and an anchor delivery catheter. The locating catheter has a distal end which can be advanced beneath the valve annulus near a target site on an upper surface of the valve annulus. The anchor delivery catheter has a distal end which can be advanced over the valve annulus to deliver an anchor along a delivery path to the target site. The distal end of the locating catheter has at least one magnetic element, and the distal end of the anchor delivery catheter has at least one magnetic element which attracts the at least one magnetic element on the locating catheter to pivotally couple the distal end of the anchor delivery catheter to the distal end of the locating catheter. In this way, the deliver catheter can be pivoted relative to the locating catheter to orient the delivery path away from the locating catheter.Type: ApplicationFiled: March 2, 2022Publication date: June 16, 2022Applicant: Elixir Medical CorporationInventors: Motasim SIRHAN, John YAN, Vinayak BHAT, Joseph PARASCHAC, Benjamyn SERNA
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Publication number: 20220125450Abstract: An aspiration catheter for removing clot from a blood vessel includes a catheter body having a scaffold extending distally from a distal end of the body. An aspiration lumen runs from the distal end to a proximal end of the body, and a central clot-receiving passage in the scaffold is contiguous with the aspiration lumen of the catheter body. A vacuum-resistant membrane covers the scaffold and establishes a clot aspiration path from a distal end of the scaffold to a proximal end of the aspiration lumen, in the catheter body so that applying a vacuum to the proximal end of the aspiration lumen can draw clot into the central clot-receiving passage. The scaffold may have a comical configuration, a cylindrical configuration, or a combination thereof, and at least a distal portion of the scaffold is radially expandable from a delivery configuration to an extraction configuration.Type: ApplicationFiled: January 4, 2022Publication date: April 28, 2022Applicant: Elixir Medical CorporationInventors: MOTASIM SIRHAN, VINAYAK BHAT, BENJAMYN SERNA, SAMIT MUSTAFA, BRETT CRYER, KIM NGUYEN, JOHN YAN
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Publication number: 20220039976Abstract: Devices, systems, and methods are provided including a structure having one or more surfaces configured for internal use within a patient's body and one or more therapeutic compositions comprising one or more active substances including a direct factor Xa inhibitor, and a direct factor IIa inhibitor disposed in or on the structure. The structure is configured to be positioned adjacent an injury site in the patient's body. The one or more active substances optionally include an anti-proliferative agent. The therapeutic composition is formulated to release the one or more active substances to the injury site to provide one or more of inhibit clot formation, promote clot dissolution, inhibit or dissolute inflammation, inhibit vessel injury, increase time before clotting, and/or inhibit cell proliferation.Type: ApplicationFiled: August 13, 2021Publication date: February 10, 2022Applicant: Elixir Medical CorporationInventors: John Yan, Xiaoxia Zheng, Vinayak D. Bhat, Motasim Sirhan
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Patent number: 11191656Abstract: A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.Type: GrantFiled: March 8, 2021Date of Patent: December 7, 2021Assignee: Elixir Medical CorporationInventors: Motasim Sirhan, Vinayak Bhat, Joseph Paraschac, Benjamyn Serna, John Yan
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Publication number: 20210186722Abstract: A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.Type: ApplicationFiled: March 8, 2021Publication date: June 24, 2021Applicant: Elixir Medical CorporationInventors: Motasim Sirhan, Vinayak Bhat, Joseph Paraschac, Benjamyn Serna, John Yan
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Patent number: 10973662Abstract: A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.Type: GrantFiled: October 16, 2020Date of Patent: April 13, 2021Assignee: Elixir Medical CorporationInventors: Motasim Sirhan, Vinayak Bhat, Joseph Paraschac, Benjamyn Serna, John Yan
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Patent number: 10918505Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.Type: GrantFiled: September 10, 2020Date of Patent: February 16, 2021Assignee: Elixir Medical CorporationInventors: Motasim Sirhan, John Yan, Vinayak Bhat, Joseph Paraschac, Brett Cryer, Benjamyn Serna
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Publication number: 20210038411Abstract: A system for reshaping a valve annulus includes an elongate template having a length along a longitudinal axis and at least one concavity in a generally lateral direction along said length. The pre-shaped template is positioned against at least a region of an inner peripheral wall of the valve annulus, and at least one anchor on the template is advanced into a lateral wall of the valve annulus to reposition at least one segment of the region of the inner peripheral wall of the valve annulus into said concavity. In this way, a peripheral length of the valve annulus can be foreshortened and/or reshaped to improve coaption of the valve leaflets and/or to eliminate or decrease regurgitation of a valve.Type: ApplicationFiled: October 16, 2020Publication date: February 11, 2021Applicant: Elixir Medical CorporationInventors: Motasim Sirhan, Vinayak Bhat, Joseph Paraschac, Benjamyn Serna, John Yan