Patents by Inventor Motoaki Tanaka
Motoaki Tanaka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8058261Abstract: To provide a compound which exhibits excellent anti-tumor activity and excellent oral absorption and which is a useful anti-tumor drug. The invention provides a 3?-ethynylcytidine derivative represented by formula (1): (wherein X represents a (substituted) alkylcarbonyl group, a (substituted) alkoxycarbonyl group, or a hydrogen atom; one of Y and Z represents a hydrogen atom or a group represented by (R1)(R2)(R3)Si— and the other represents a group represented by (R4)(R5)(R6)Si—; and R1, R2, R3, R4, R5, and R6 each represent a (substituted) alkyl group, a (substituted) cyclic alkyl group, or a (substituted) aryl group) or a salt thereof.Type: GrantFiled: July 23, 2007Date of Patent: November 15, 2011Assignees: Taiho Pharmaceutical Co., Ltd.Inventors: Motoaki Tanaka, Masakazu Fukushima
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Publication number: 20090306008Abstract: To provide a compound which exhibits excellent anti-tumor activity and excellent oral absorption and which is a useful anti-tumor drug. The invention provides a 3?-ethynylcytidine derivative represented by formula (1): (wherein X represents a (substituted) alkylcarbonyl group, a (substituted) alkoxycarbonyl group, or a hydrogen atom; one of Y and Z represents a hydrogen atom or a group represented by (R1)(R2)(R3)Si— and the other represents a group represented by (R4)(R5)(R6)Si—; and R1, R2, R3, R4, R5, and R6 each represent a (substituted) alkyl group, a (substituted) cyclic alkyl group, or a (substituted) aryl group) or a salt thereof.Type: ApplicationFiled: July 23, 2007Publication date: December 10, 2009Applicants: TAIHO PHARMACEUTICAL CO., LTDInventors: Motoaki Tanaka, Masakazu Fukushima
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Patent number: 5880294Abstract: The present invention relates to D-pentofuranose derivatives represented by the following formulas (1) through (4): ##STR1## (wherein A represents a chlorobenzoyl group; R.sup.1 represents a hydrogen atom, an aliphatic lower acyl group, a substituted or unsubstituted benzoyl group; each of X and Y represents a lower alkyl group; Z represents an ethynyl group or tri-lower alkyl silylethynyl group; the sugar moiety in formula (1) represents xylose; and the sugar moiety of each of formulas (3) and (4) represents ribose). The present invention also relates to a process for preparing the compound (2) characterized by oxidizing the compound of formula (1) with a hypochlorite in the presence of a catalytic amount of 2,2,6,6-tetramethylpiperidinoxy compound, and these compounds are useful as intermediates in the synthesis of 3'-C-substituted ribonucleoside derivatives having excellent antitumor activities.Type: GrantFiled: January 6, 1998Date of Patent: March 9, 1999Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Makoto Nomura, Hideki Kazuno, Tsutomu Sato, Masato Washinosu, Motoaki Tanaka, Akira Matsuda, Tetsuji Asao
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Patent number: 5728841Abstract: This invention is to provide a process for preparing 1-amino-1,2,3-triazole represented by formula (III): ##STR1## comprising cyclizing glyoxal bishydrazone represented by formula (I): ##STR2## by reaction with an aqueous hydrogen peroxide solution in the presence of a catalytic amount of a transition metal oxide represented by formula (II):M.sub.m O.sub.nwherein M represents a transition metal atom; and m and n, which may be the same or different, each represent an integer of 1 to 5.Type: GrantFiled: April 30, 1996Date of Patent: March 17, 1998Assignee: Taiho Pharmaceutical Co., Ltd.Inventors: Kazuhiko Shigeno, Tomoyasu Ono, Motoaki Tanaka, Shozo Yamada, Tetsuji Asao
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Patent number: 5310926Abstract: The present invention provides a process for producing isoxazole derivatives represented by the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are each a hydrogen atom or lower alkoxyl, and R.sup.3 is cyano or alkoxycarbonyl, the process being characterized by oxidizing an .alpha., .beta.-unsaturated ketoxime derivative represented by the formula ##STR2## wherein R.sup.1 , R.sup.2 and R.sup.3 are as defined above. The isoxazole derivatives (II) to be produced by the process of the present invention are useful as intermediates for preparing (3,4-diarylisoxazol-5-yl) acetic acid derivatives which are useful as anti-inflammatory agents, analgesics and antipyretics.Type: GrantFiled: September 16, 1993Date of Patent: May 10, 1994Assignee: Taiho Pharmaceutical Co., LimitedInventors: Yu-ichi Hagiwara, Motoaki Tanaka, Makoto Kajitani, Mitsugi Yasumoto
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Patent number: 5142091Abstract: The present invention provides an .alpha., .beta.-unsaturated ketone and ketoxime derivative represented by the formula ##STR1## wherein Y is oxygen atom or hydroxyimino group, Z is cyano or alkoxycarbonyl group, R.sup.1 and R.sup.2 are the same or different and are each hydrogen atom or lower alkoxyl group.The .alpha., .beta.-unsaturated ketones and ketoxime derivatives of the invention are useful as an intermediate for preparing a (3,4-diarylisoxazol-5-yl)acetic acid derivatives which is useful as an anti-inflammatory agent, analgesic and antipyretic.Type: GrantFiled: July 10, 1991Date of Patent: August 25, 1992Assignee: Taiho Pharmaceutical Company LimitedInventors: Motoaki Tanaka, Yu-ichi Hagiwara, Makoto Kajitani, Mitsugi Yasumoto
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Patent number: 4990600Abstract: Cyclic azoamidine compounds having the formula and salts thereof are disclosed. ##STR1## wherein R denotes a methyl group or an ethyl group, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently denote a lower alkyl group having one to four carbon atoms or a hydrogen atoms, provided that a case where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are all hydrogen atoms is excluded. The cyclic azoamidine compounds and their salts are useful as polymerization initiators in the production of polymer compounds.Type: GrantFiled: February 27, 1990Date of Patent: February 5, 1991Assignee: Wako Pure Chemical Industries Ltd.Inventors: Motoaki Tanaka, Tsutomu Miyagawa, Kazuo Shiraki
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Patent number: 4950742Abstract: An azoimino ether, which is an intermediate for preparing polymerization initiators, is prepared by reacting a hydrazonitrile having a hydrazo group and at least one cyano group in the molecule with chlorine in the presence of an alcohol, in a non-aqueous organic solvent.Type: GrantFiled: March 6, 1989Date of Patent: August 21, 1990Assignee: Wako Pure Chemical Industries, Ltd.Inventors: Kazuo Ichiriki, Motoaki Tanaka, Toru Okugawa, Hiroyoshi Nawa
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Patent number: 4933444Abstract: Disclosed is a process for preparing 2.beta.-substituted-methylpenicillin derivative of the formula ##STR1## wherein R is H or carboxyl protecting group, R.sub.1 is H or halo, R.sub.2 is H, lower alkyl, lower alkoxy, halogen, azido, lower alkylthio, phthalimide or a group --NHR.sub.3 (wherein R.sub.3 is H or acyl), and --N Y is an optionally substituted monocyclic or bicyclic heterocyclic group having 1 to 4 nitrogen atoms in the ring structure, the process comprising reacting a compound of the formula ##STR2## wherein X is Cl or Br, and R, R.sub.1 and R.sub.2 are as defined above with a heterocyclic compound of the formula ##STR3## wherein --N Y is as defined above.Type: GrantFiled: June 26, 1989Date of Patent: June 12, 1990Assignees: Taiho Pharmaceutical Co., Ltd., Otsuka Kagaku Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Motoaki Tanaka, Shozo Yamada, Akira Nakai, Hisashi Ohbayashi
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Patent number: 4916216Abstract: Granules of azobisamidine salt can be produced by granulating a powder of azobisamidine salt using a limited amount of water or a mixture of water and a water-soluble organic solvent such as methanol are convenient in handling without deteriorating the quality and can be used as a water-soluble polymerization initiator.Type: GrantFiled: May 11, 1987Date of Patent: April 10, 1990Assignee: Wako Pure Chemical Industries, Ltd.Inventors: Motoaki Tanaka, Takanori Toyama, Hiroki Sugioka
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Patent number: 4912213Abstract: The present invention provides a process for preparing a penicillanic acid derivative of the formula ##STR1## which comprises reacting lead with a halogenated penicillanic acid derivative of the formula ##STR2## wherein X, Y, Z and R.sup.1 are as defined in the specification. The reaction is advantageously conducted in the presence of a metal having higher ionization tendency than lead such as aluminum, iron, magnesium or a mixture thereof.Type: GrantFiled: September 7, 1988Date of Patent: March 27, 1990Assignees: Otsuka Kagaku Kabushiki Kaisha, Taiho Pharmaceutical Company, LimitedInventors: Masatoshi Taniguchi, Michio Sasaoka, Kiyotoshi Matsumura, Ichiro Kawahara, Kenji Kase, Daisuke Suzuki, Shigeru Torii, Hideo Tanaka, Motoaki Tanaka, Akira Nakai
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Patent number: 4898939Abstract: A process for preparing a 2.beta.-substituted-methylpenicillin compound of the formula ##STR1## wherein --N Y is an optionally substituted heterocyclic group containing 2 to 4 nitrogen atoms as the hetero atom in the ring structure, and R.sub.1 is a penicillin carboxyl protecting group, the process comprising reacting an azetidinonedisulfide compound of the formula ##STR2## wherein R.sub.1 is as defined above and R is a substituted or unsubstituted heterocyclic group with a nitrogen-containing heterocyclic compound of the formula ##STR3## wherein ##STR4## is as defined above in the presence of a metal compound.Type: GrantFiled: February 28, 1989Date of Patent: February 6, 1990Assignees: Taiho Pharmaceutical Co., Ltd., Otsuka Kagaku Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Motoaki Tanaka, Shozo Yamada, Akira Nakai
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Patent number: 4895941Abstract: 2.alpha.-Methyl-2.beta.-(1,2,3-triazol-1-yl)methylpenam-3.alpha.-carboxylic acid derivatives are prepared by reacting a penicillanic acid sulfoxide derivative of the formula ##STR1## wherein R is a penicillin carboxyl protecting group, and R.sub.1 is hydrogen or halogen, R.sub.2 is hydrogen, lower alkyl or the like with a triazole derivative of the formula ##STR2## wherein R.sub.3 and R.sub.4 are hydrogen, trialkylsilyl, lower alkyl, lower alkoxy or the like and R.sub.5 is hydrogen or silyl substituted with 3 groups selected from the class consisting of lower alkyl, benzyl and phenyl in a solvent.Type: GrantFiled: February 28, 1989Date of Patent: January 23, 1990Assignees: Taiho Pharmaceutical Co., Ltd., Otsuka Kagaku Kabushiki KaishaInventors: Sigeru Torii, Hideo Tanaka, Motoaki Tanaka, Shozo Yamada, Akira Nakai
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Patent number: 4891369Abstract: Disclosed are 2.beta.-substituted-methylpenicillanic acid compounds of the formula ##STR1## wherein n is 0, 1 or 2; and ##STR2## is monocyclic or bicyclic heterocyclic ring group which has 2 to 4 nitrogen atoms as hetero atom in its ring structure and which may be optionally substituted with alkyl, alkoxycarbonyl, phenyl, formyl or benzyloxycarbonyl optionally having alkyl, nitro or a halogen atom on the benzene ring, with the proviso that said heterocyclic ring group is not 1,2,3-triazol-1-yl; or salts or esters thereof.These compounds are useful as .beta.-lactamase inhibitor.Type: GrantFiled: November 23, 1987Date of Patent: January 2, 1990Assignee: Taiho Pharmaceutical Company, LimitedInventors: Sigeru Torii, Hideo Tanaka, Motoaki Tanaka, Shozo Yamada, Akira Nakai, Hisashi Ohbayashi, Tomoyasu Ohno
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Patent number: 4861768Abstract: Disclosed is a penicillin derivative of the formula: ##STR1## wherein n is an integer of 0, 1 or 2; Y is a cyano group, a lower acyl group, a mono- or di-lower alkylthiocarbamoyl group, ##STR2## wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a phenyl group, a group --(CH.sub.2).sub.m --OR.sub.2 or --(CH.sub.2).sub.m COOR.sub.2 (m is an integer of 1 to 6 and R.sub.2 is a hydrogen atom or a penicillin carboxyl ester-forming group which is commonly used for penicillin derivatives) or a phenyl group substituted by at least one member selected from the class consisting of lower alkyl group, halogen atom and lower alkoxy group; and R is a hydrogen atom or a penicillin carboxyl ester-forming group, or a salt thereof. They are useful as .beta.-lactamase inhibitors.Type: GrantFiled: February 18, 1987Date of Patent: August 29, 1989Assignee: Taiho Pharmaceutical Company, LimitedInventors: Sigeru Torii, Hideo Tanaka, Motoaki Tanaka, Shozo Yamada, Akira Nakai, Hisashi Ohbayashi
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Patent number: 4840881Abstract: A process for the preparation of a light-sensitive silver halide photographic material comprising a support, a silver halide emulsion layer, and a non-light-sensitive hydrophilic colloid layer which consists essentially of a plurality of layer elements; a process comprises incorporating oil particles into at least one of the elements, so that the oil particle density of the outermost layer element is not the highest of the oil particle densities of all of the elements.Type: GrantFiled: July 21, 1988Date of Patent: June 20, 1989Assignee: Konishiroku Photo Industry Co., Ltd.Inventors: Yoshikazu Watanabe, Motoaki Tanaka
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Patent number: 4826959Abstract: A mixture of an isomer of 2,2'-azobis(2,4-dimethylvaleronitrile) having a low melting point in an amount of about 70% by weight or more and an isomer of 2,2'-azobis(2,4-dimethylvaleronitrile) having a high melting point in an amount of about 30% by weight or less shows excellent solvent solubility, which is higher than that of the isomer having a low melting point. The mixture is useful as a polymerization initiator, and also as a blowing agent.Type: GrantFiled: January 29, 1988Date of Patent: May 2, 1989Assignee: Wako Pure Chemical Industries, Ltd.Inventors: Motoaki Tanaka, Tsutomu Miyagawa, Hideo Takeuchi
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Patent number: 4777251Abstract: An improved process for preparing oxytitanium phthalocyanine is provided wherein the condensation reaction of o-phthalodinitrile with titanium tetrachloride is effected in an organic solvent at 170.degree. to 300.degree. C. followed by hydrolysis, the improvement wherein said organic solvent is preliminarily heated at a temperature of 160.degree. to 300.degree. C. prior to initiation of the condensation reaction. The A form of oxytitanium phthalocyanine crystal can selectively be produced in the pure state.Type: GrantFiled: April 27, 1987Date of Patent: October 11, 1988Assignees: Mitsubishi Kasei Corporation, Waco Pure Chemical Industries, Ltd.Inventors: Motoaki Tanaka, Tutomu Miyagawa, Iwao Takagishi
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Patent number: 4694053Abstract: The invention provides an improvement in the suspension polymerization of vinyl chloride in an aqueous medium in the presence of a monomer-soluble polymerization initiator, according to which the amount of polymer scale deposition on the reactor walls can be greatly decreased. The improvement comprises admixing the aqueous polymerization medium with (a) a water-soluble crosslinked copolymer of an unsaturated carboxylic acid monomer, e.g. acrylic acid, and a crosslinking monomer such as di(methyl)allyl ether of diethyleneglycol and (b) a non-ionic surface active agent in combination.Type: GrantFiled: June 25, 1985Date of Patent: September 15, 1987Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Kenichi Itoh, Genji Noguki, Motoaki Tanaka, Hitoshi Ohba
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Patent number: RE33284Abstract: The invention provides an improvement in the suspension polymerization of vinyl chloride in an aqueous medium in the presence of a monomer-soluble polymerization initiator, according to which the amount of polymer scale deposition on the reactor walls can be greatly decreased. The improvement comprises admixing the aqueous polymerization medium with (a) a water-soluble crosslinked copolymer of an unsaturated carboxylic acid monomer, e.g. acrylic acid, and a crosslinking monomer such as di(methyl)allyl ether of diethyleneglycol and (b) a non-ionic surface active agent in combination.Type: GrantFiled: November 30, 1987Date of Patent: July 31, 1990Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Kenichi Itoh, Genji Noguki, Motoaki Tanaka, Hitoshi Ohba, Masahiko Watase