Patents by Inventor Motohide Takahashi

Motohide Takahashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for quantification of neurotoxin
    Patent number: 8949033
    Abstract: The present invention relates to a method for quantitatively measuring the muscular relaxing activity of a neurotoxin.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: February 3, 2015
    Assignees: The Chemo-Sero-Therapeutic Research Institute, Japan as represented by Director General of National Institute of Infectious Diseases
    Inventors: Tetsuhiro Harakawa, Hirotoshi Nakano, Yasushi Torii, Sachio Okuda, Ryuji Kaji, Takashi Sakamoto, Motohide Takahashi, Setsuji Ishida
  • Method for quantification of neurotoxin
    Patent number: 8577618
    Abstract: The present invention relates to a method for quantitatively measuring the muscular relaxing activity of a neurotoxin.
    Type: Grant
    Filed: April 28, 2006
    Date of Patent: November 5, 2013
    Assignees: The Chemo-Sero-Therapeutic Research Institute, Japan as represented by Director Genereal of National Institute of Infectious Diseases
    Inventors: Tetsuhiro Harakawa, Hirotoshi Nakano, Yasushi Torii, Sachio Okuda, Ryuji Kaji, Takashi Sakamoto, Motohide Takahashi, Setsuji Ishida
  • Composition for neutralizing botulinus toxin type-A, and human anti-botulinus toxin type-A antibody
    Patent number: 8540987
    Abstract: Provided herein is a means which is effective for botulism diseases and the prevention of the botulism diseases. Specifically provided is a plurality of human anti-botulinum toxin type-A antibodies having different epitopes from one another. Also specifically provided is a composition for neutralizing botulinum toxin type-A, which comprises a combination of two or more of the antibodies and which has a high neutralizing activity.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: September 24, 2013
    Assignees: Institute for Antibodies Co., Ltd., Japan as Represented by Director-General of National Institute of Infectious Diseases, Osaka Prefecture University Public Corporation
    Inventors: Masachika Azuma, Motohide Takahashi, Shunji Kozaki, Masafumi Mukamoto, Tomoko Kohda, Gene Kurosawa, Yoshikazu Kurosawa
  • Antibody library
    Patent number: 8101553
    Abstract: An antibody library is prepared by selecting a light chain variable region capable of binding to the variable region of heavy chain to reproduce an active conformation and using the same. Because of being capable of maintaining the diversity of the heavy chain variable region at a high ratio in vitro, the antibody library of the present invention is expected as enabling the acquisition of antibodies with various binding activities.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: January 24, 2012
    Assignee: Medical & Biological Laboratories Co., Ltd.
    Inventors: Yoshikazu Kurosawa, Yasushi Akahori, Yoshitaka Iba, Kazuhiko Morino, Midori Shinohara, Motohide Takahashi, Yoshinobu Okuno, Kimiyasu Shiraki
  • METHOD FOR QUANTIFICATION OF TITER OF NEUTRALIZING ANTIBODY TO NEUROTOXIN
    Publication number: 20110105940
    Abstract: A method for quantification of a titer of a neutralizing antibody to a neurotoxin is disclosed. The method comprises the steps: (a) mixing a standard sample containing a fixed amount of a neurotoxin and a test sample containing a neutralizing antibody to said neurotoxin; (b) administering the mixture obtained in step (a) into the muscle of a non-human mammal; (c) applying electric stimulus to said non-human mammal; (d) measuring a compound muscle action potential (CMAP) due to contraction of the muscle of said mammal by application of electric stimulus with an electromyograph; and (e) analyzing CMAP amplitude data obtained in step (d) for an extent of decrease in amplitude by a non-neutralized neurotoxin to thereby quantify a titer of the neutralizing antibody contained in the test sample.
    Type: Application
    Filed: August 20, 2008
    Publication date: May 5, 2011
    Applicants: JURIDICAL FDN THE CHEMO-SERO-THERAPEUTIC RES. INS., JP AS REP BY DIR-GEN NATL INST OF INFECTIOUS DIS
    Inventors: Yasushi Torii, Tetsuhiro Harakawa, Yoshitaka Goto, Akihiro Ginnaga, Ryuji Kaji, Shunji Kozaki, Motohide Takahashi
  • COMPOSITION FOR NEUTRALIZING BOTULINUS TOXIN TYPE-A, AND HUMAN ANTI-BOTULINUS TOXIN TYPE-A ANTIBODY
    Publication number: 20110014211
    Abstract: Provided herein is a means which is effective for botulism diseases and the prevention of the botulism diseases. Specifically provided is a plurality of human anti-botulinum toxin type-A antibodies having different epitopes from one another. Also specifically provided is a composition for neutralizing botulinum toxin type-A, which comprises a combination of two or more of the antibodies and which has a high neutralizing activity.
    Type: Application
    Filed: January 23, 2009
    Publication date: January 20, 2011
    Applicants: Institute for Antibodies Co., Ltd., Japan as Represented by Director-General of National Institute of Infectious Disesases, Osaka Prefecture University Public Corporation
    Inventors: Masachika Azuma, Motohide Takahashi, Shunji Kozaki, Masafumi Mukamoto, Tomoko Kohda, Gene Kurosawa, Yoshikazu Kurosawa
  • Device for discriminating between two values of a signal with DC offset compensation
    Patent number: 4363977
    Abstract: A device for discriminating between two values of a signal using DC offset compensation including an automatic gain control circuit, a peak detector circuit and a feedback path from the peak detector circuit to the input circuit of the automatic gain control circuit. The value of the feedback current is regulated so that the maximum value of one of the same polarity signals and the opposite polarity signal coincides with the minimum value of the other of the two signals.
    Type: Grant
    Filed: February 20, 1981
    Date of Patent: December 14, 1982
    Assignee: Fujitsu Limited
    Inventors: Toshitaka Tsuda, Kazuo Murano, Kazuo Yamaguchi, Takafumi Chujo, Norio Murakami, Motohide Takahashi