Abstract: The present invention addresses the issue of providing a norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration which vaccine can readily immunize the target cells, an associated product of a molecular needle serving as an active ingredient of the vaccine, and a production method for the associated product. The invention provides a norovirus component vaccine containing, as an active ingredient, an associated product including a hexamer formed through bonding of two molecules of a trimer of a molecular needle represented by the following formula (1). W-L1-Xn—Y (1) [wherein W represents an amino acid sequence of P domain of the capsid protein of norovirus as an immunogen; L1 represents a first linker sequence having 0 to 100 amino acids; X represents an amino acid sequence represented by SEQ ID NO: 1; Y represents an amino acid sequence of a cell introduction domain; n is an integer of 1 to 3].

Abstract: A radial-gap type superconducting synchronous machine 1 is prepared which includes a rotor 20 having, on its peripheral side, a convex magnetic pole 21 which includes, at its distal end part, bulk superconductors 30. When viewed in the direction of the rotational axis C1 of the rotor 20, the magnetic pole center side of the bulk superconductors 30 is disposed nearer to a stator 10 than the magnetic pole end side of the bulk superconductors 30. A ferromagnet 28 is disposed on the rotational axis C1 side of the bulk superconductors 30. A magnetizing apparatus 100 is disposed outside the bulk superconductors 30 in the radial direction of the rotor 20. Magnetization of the bulk superconductors 30 is performed by directing magnetic flux lines from the magnetizing apparatus 100 toward the bulk superconductors 30.

Abstract: An object of the present invention is to solve problems in terms of stagnation of research on norovirus by providing a cultured transgenic cell or a transgenic animal in which murine norovirus (MNV) can be grown across the barrier of host specificity in mammalian cells, and providing a screening method that uses the cultured transgenic cell or the transgenic animal. The present inventors have found that MNV infection is determined in a cultured transgenic mammalian cell or a mammal possessing the cultured transgenic mammalian cell as its own cell, the cultured transgenic mammalian cell containing one or more species selected from the entirety or a portion of the murine CD300F gene and/or a CD300 family gene having an extracellular domain nucleotide sequence similar to that of the murine CD300F gene. The present inventors have solved the aforementioned problems by providing, for example, a norovirus-related drug screening method on the basis of this finding.

Abstract: The present invention addresses the issue of providing a norovirus component vaccine for subcutaneous, intradermal, percutaneous, or intramuscular administration which vaccine can readily immunize the target cells, an associated product of a molecular needle serving as an active ingredient of the vaccine, and a production method for the associated product. The invention provides a norovirus component vaccine containing, as an active ingredient, an associated product including a hexamer formed through bonding of two molecules of a trimer of a molecular needle represented by the following formula (1). W-L1-Xn—Y (1) [wherein W represents an amino acid sequence of P domain of the capsid protein of norovirus as an immunogen; L1 represents a first linker sequence having 0 to 100 amino acids; X represents an amino acid sequence represented by SEQ ID NO: 1; Y represents an amino acid sequence of a cell introduction domain; n is an integer of 1 to 3].

Abstract: A radial-gap type superconducting synchronous machine 1 is prepared which includes a rotor 20 having, on its peripheral side, a convex magnetic pole 21 which includes, at its distal end part, bulk superconductors 30. When viewed in the direction of the rotational axis C1 of the rotor 20, the magnetic pole center side of the bulk superconductors 30 is disposed nearer to a stator 10 than the magnetic pole end side of the bulk superconductors 30. A ferromagnet 28 is disposed on the rotational axis C1 side of the bulk superconductors 30. A magnetizing apparatus 100 is disposed outside the bulk superconductors 30 in the radial direction of the rotor 20. Magnetization of the bulk superconductors 30 is performed by directing magnetic flux lines from the magnetizing apparatus 100 toward the bulk superconductors 30.

Abstract: A radial-gap type superconducting synchronous machine 1 is prepared which includes a rotor 20 having, on its peripheral side, a convex magnetic pole 21 which includes, at its distal end part, bulk superconductors 30. When viewed in the direction of the rotational axis C1 of the rotor 20, the magnetic pole center side of the bulk superconductors 30 is disposed nearer to a stator 10 than the magnetic pole end side of the bulk superconductors 30. A ferromagnet 28 is disposed on the rotational axis C1 side of the bulk superconductors 30. A magnetizing apparatus 100 is disposed outside the bulk superconductors 30 in the radial direction of the rotor 20. Magnetization of the bulk superconductors 30 is performed by directing magnetic flux lines from the magnetizing apparatus 100 toward the bulk superconductors 30.

Abstract: A rotary machine cools a cooling target inside a rotor rotatable around a rotational axis, includes a condenser section disposed outside the rotor and condenses a gas phase cooling medium into a liquid phase cooling medium; an evaporator section disposed inside the rotor, and evaporates the liquid phase cooling medium generated by condensation in the condenser section into the gas phase cooling medium, by heat exchange between the cooling target and the liquid phase cooling medium; and a coupling pipe flows the liquid phase cooling medium and the gas phase cooling medium between the evaporator section and the condenser section, wherein the coupling pipe has a pipe structure in which a liquid phase cooling medium passage flows the liquid phase cooling medium generated by the condensation in the condenser section and a gas phase cooling medium passage flows the gas phase cooling medium generated by evaporation in the evaporator section.

Abstract: Provided is a rotary machine capable of increasing cooling efficiency while preventing an increase in the weight and cost of a rotor even in a case where the diameter of the rotor is increased.

Abstract: A superconducting bulk magnet comprising a plurality of superconducting bulk materials combined, in which breakage of superconducting bulk materials is prevented and a strong magnetic field can be generated, that is, a superconducting bulk magnet comprising a plurality of superconducting bulk materials, each comprising a single-crystal formed RE1Ba2Cu3Oy (RE is one or more elements selected from Y or rare earth elements, where 6.8?y?7.

Abstract: An object of the present invention is to solve problems in terms of stagnation of research on norovirus by providing a cultured transgenic cell or a transgenic animal in which murine norovirus (MNV) can be grown across the barrier of host specificity in mammalian cells, and providing a screening method that uses the cultured transgenic cell or the transgenic animal. The present inventors have found that MNV infection is determined in a cultured transgenic mammalian cell or a mammal possessing the cultured transgenic mammalian cell as its own cell, the cultured transgenic mammalian cell containing one or more species selected from the entirety or a portion of the murine CD300F gene and/or a CD300 family gene having an extracellular domain nucleotide sequence similar to that of the murine CD300F gene. The present inventors have solved the aforementioned problems by providing, for example, a norovirus-related drug screening method on the basis of this finding.

Abstract: Provided is a rotary machine capable of increasing cooling efficiency while preventing an increase in the weight and cost of a rotor even in a case where the diameter of the rotor is increased.

Abstract: A rotary machine cools a cooling target inside a rotor rotatable around a rotational axis, includes a condenser section disposed outside the rotor and condenses a gas phase cooling medium into a liquid phase cooling medium; an evaporator section disposed inside the rotor, and evaporates the liquid phase cooling medium generated by condensation in the condenser section into the gas phase cooling medium, by heat exchange between the cooling target and the liquid phase cooling medium; and a coupling pipe flows the liquid phase cooling medium and the gas phase cooling medium between the evaporator section and the condenser section, wherein the coupling pipe has a pipe structure in which a liquid phase cooling medium passage flows the liquid phase cooling medium generated by the condensation in the condenser section and a gas phase cooling medium passage flows the gas phase cooling medium generated by evaporation in the evaporator section.

Abstract: A superconducting bulk magnet comprising a plurality of superconducting bulk materials combined, in which breakage of superconducting bulk materials is prevented and a strong magnetic field can be generated, that is, a superconducting bulk magnet comprising a plurality of superconducting bulk materials, each comprising a single-crystal formed RE1Ba2Cu3Oy (RE is one or more elements selected from Y or rare earth elements, where 6.8?y?7.

Abstract: A radial-gap type superconducting synchronous machine 1 is prepared which includes a rotor 20 having, on its peripheral side, a convex magnetic pole 21 which includes, at its distal end part, bulk superconductors 30. When viewed in the direction of the rotational axis C1 of the rotor 20, the magnetic pole center side of the bulk superconductors 30 is disposed nearer to a stator 10 than the magnetic pole end side of the bulk superconductors 30. A ferromagnet 28 is disposed on the rotational axis C1 side of the bulk superconductors 30. A magnetizing apparatus 100 is disposed outside the bulk superconductors 30 in the radial direction of the rotor 20. Magnetization of the bulk superconductors 30 is performed by directing magnetic flux lines from the magnetizing apparatus 100 toward the bulk superconductors 30.

Abstract: An anti-human-norovirus GII antibody which responds to substantially all genotypes of the human noroviruses belonging to GII and which can comprehensively detect such human noroviruses GII. The anti-human-norovirus GII antibody that binds to at least one of epitopes which are contained in amino acid regions represented by the following formulas (1) and (2): P-X1-X2-P-G-E??(1) (SEQ ID NO: 2) X3-X4-X5-F-Y-X6-L-X7-P-X8??(2) (SEQ ID NO: 3) (wherein, X1 represents L, V, N, T, S, M, or R; X2 represents F, Y, or M; X3 represents V or G; X4 represents N or S; X5 represents Q, P, or S; X6 represents S, T, or I; X7 represents A or S; and X8 represents M or V), and of an epitope formed of amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1, or an epitope formed of an amino acid corresponding to amino acid 483, the regions and the amino acids being present in the P domain of a capsid structural protein of a human norovirus GII.

Abstract: Provided is an anti-human-norovirus GII antibody which responds to substantially all genotypes of the human noroviruses belonging to GII and which can comprehensively detect such human noroviruses GII. The anti-human-norovirus GII antibody that binds to at least one of epitopes which are contained in amino acid regions represented by the following formulas (1) and (2): P-X1-X2-P-G-E??(1) X3-X4-X5-F-Y-X6-L-X7-P-X8??(2) (wherein, X1 represents L, V, N, T, S, M, or R; X2 represents F, Y, or M; X3 represents V or G; X4 represents N or S; X5 represents Q, P, or S; X6 represents S, T, or I; X7 represents A or S; and X8 represents M or V), and of an epitope formed of amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1, or an epitope formed of an amino acid corresponding to amino acid 483, the regions and the amino acids being present in the P domain of a capsid structural protein of a human norovirus GII.

Abstract: A joint includes a housing and a refrigerant tube connected to a refrigerant source and communicated with a target part in a rotating machine. A rotating member is loosely fitted inside with the refrigerant tube and fixed to a rotary part of the rotating machine. A relatively rotating member has a fixed-side member and rotating-side member. The fixed-side member is connected to the refrigerant tube via a refrigerant tube extension section. The rotating-side member is connected to the rotating member via a rotating member extension section. A refrigerant zone is formed by spaces defined between the refrigerant tube and the rotating member, and between the refrigerant tube and rotating member extension sections. A sealing member is installed between the fixed-side and rotating-side members. A vacuum chamber and pressure chamber are defined within the housing.

Abstract: Problem to be Solved To provide a small, lightweight, cryo-rotary joint. Solution A joint includes a housing 2, a refrigerant tube 3 connected to a refrigerant source and communicated with a target part in a rotating machine, a rotating member 4 loosely fitted inside with the refrigerant tube and fixed to a rotary part of the rotating machine, and a relatively rotating member 5 having a fixed-side member 5a and rotating-side member 5b, wherein the fixed-side member is connected to the refrigerant tube via a refrigerant tube extension section 3a, the rotating-side member is connected to the rotating member via a rotating member extension section 4a, a refrigerant zone is formed by spaces 7 and 8 defined by the refrigerant tube, rotating member, and refrigerant tube and rotating member extension sections, a sealing member 10 is installed between the fixed-side and rotating-side members, and a vacuum chamber and pressure chamber are defined within the housing.