Patents by Inventor Motoi Hanada

Motoi Hanada has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Screening assays for identifying agents that regulate the expression of genes involved in cell death
    Patent number: 5908750
    Abstract: The present invention provides regulatory elements that are linked to genes involved in cell death. For example, the present invention provides a p53-RE.sup.D, which is involved in p53-mediated down-regulation of the bcl-2 gene, and the bax promotor, which contains a p53-RE.sup.U that is involved in p53-mediated up-regulation of the bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death. In addition, the invention provides methods for modulating the level of apoptosis in a cell.
    Type: Grant
    Filed: April 11, 1997
    Date of Patent: June 1, 1999
    Assignee: Le Jolla Cancer Research Foundation
    Inventors: John C. Reed, Toshiyuki Miyashita, Masayoshi Harigai, Motoi Hanada
  • Promotors that regulate the expression of genes involved in cell death
    Patent number: 5659024
    Abstract: The present invention provides regulatory elements that are linked to genes involved in cell death. For example, the present invention provides a p53-RE.sup.D, which is involved in p53-mediated down-regulation of the bcl-2 gene, and the bax promotor, which contains a p53-RE.sup.U that is involved in p53-mediated up-regulation of the bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death. In addition, the invention provides methods for modulating the level of apoptosis in a cell.
    Type: Grant
    Filed: October 27, 1994
    Date of Patent: August 19, 1997
    Assignee: The Burnham Institute
    Inventors: John C. Reed, Toshiyuki Miyashita, Masayoshi Harigai, Motoi Hanada
  • Method of down-regulating a gene linked to a P-53 responsive element
    Patent number: 5484710
    Abstract: The present invention provides regulatory elements that are linked to genes involved in cell death and are regulated by p53 tumor suppressor protein. Examples of such p53 responsive elements (p53-RE) include p53-RE.sup.D, which is involved in p53-mediated down-regulation of the Bcl-2 gene, and p53-RE.sup.U, which is involved in p53-mediated up-regulation of the Bax gene. The invention also provides screening assays for identifying agents such as drugs that effectively modulate expression of a gene that is involved in cell death and contains a p53-RE.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: January 16, 1996
    Assignee: La Jolla Cancer Research Foundation
    Inventors: John C. Reed, Toshiyuki Miyashita, Masayoshi Harigai, Motoi Hanada