Patents by Inventor Motoichi Kurisawa
Motoichi Kurisawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220047720Abstract: Disclosed herein is a nanoparticle composition comprising nanoparticles formed from one of: a conjugate of dimeric epigallocatechin-3-O-gallate and hyaluronic acid; a conjugate of epigallocatechin-3-O-gallate and hyaluronic acid; or a epigallocate-chin-3-O-gallate-terminated hyaluronic acid conjugate; and an active agent or a pharmaceutically acceptable salt, solvate or prodrug 0thereof suitable to treat acute myeloid leukaemia, wherein the active agent is encapsulated in the nanoparticles.Type: ApplicationFiled: December 11, 2019Publication date: February 17, 2022Applicant: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Kun Liang, Motomi Osato, Ki Hyun Bae, Nunnarpas Yongvongsoontorn, Joo Eun Chung, Qingfeng Chen, Fritz Lai, Zhisheng Her
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Patent number: 10993917Abstract: There is provided a nanocomplex having a core-shell structure. The shell of the nanocomplex comprises a functionalized hyaluronic acid while the core of the nanocomplex comprises a flavonoid encapsulating a metal-containing compound. Preferably, the flavonoid is epigallocatechin gallate (EGCG) and the hyaluronic acid is thiol-functionalized and subsequently conjugated to the flavonoid. There is also provided a method of forming the nanocomplex, a pharmaceutical composition comprising the nanocomplex, medical uses of the nanocomplex and a method of treating a patient, preferably with cancer using the nanocomplex.Type: GrantFiled: December 29, 2017Date of Patent: May 4, 2021Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Motoichi Kurisawa, Ki Hyun Bae, Susi Tan
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Patent number: 10716959Abstract: There is provided polymer-flavonoid conjugates. Flavonoid-grafted and flavonoid-terminated polymer conjugates are disclosed according to the invention. The linkage of flavonoids to the polymers has been achieved via thiol linkages. The inventive processes allow for making of the conjugates in high yield avoiding complex purification steps. The conjugates can be easily autoxidized to hydrogels with uses in many biomedical applications where a higher stability of the flavonoid is necessary. The hydrogels can be potentially used as viscosupplement, anti-adhesion film or dermal filler.Type: GrantFiled: September 1, 2014Date of Patent: July 21, 2020Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Motoichi Kurisawa, Ki Hyun Bae
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Patent number: 10463646Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.Type: GrantFiled: July 18, 2018Date of Patent: November 5, 2019Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Yongvongsoontorn Nunnarpas, Jackie Y. Ying, Joo Eun Chung, Ki Hyun Bae, Min-Han Tan, Esther Lee
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Patent number: 10406175Abstract: There is provided a polymer-flavonoid conjugate, or a pharmaceutically acceptable salt thereof, uses thereof, and methods of making thereof. The disclosed polymer-flavonoid conjugates may be useful in the therapeutic and/or prophylactic treatment of a joint condition in a subject.Type: GrantFiled: May 15, 2015Date of Patent: September 10, 2019Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Fan Lee
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Publication number: 20190262271Abstract: There is provided a nanocomplex having a core-shell structure. The shell of the nanocomplex comprises a functionalized hyaluronic acid while the core of the nanocomplex comprises a flavonoid encapsulating a metal-containing compound. Preferably, the flavonoid is epigallocatechin gallate (EGCG) and the hyaluronic acid is thiol-functionalized and subsequently conjugated to the flavonoid. There is also provided a method of forming the nanocomplex, a pharmaceutical composition comprising the nanocomplex, medical uses of the nanocomplex and a method of treating a patient, preferably with cancer using the nanocomplex.Type: ApplicationFiled: December 29, 2017Publication date: August 29, 2019Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Motoichi Kurisawa, Ki Hyun Bae, Susi Tan
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Patent number: 10221253Abstract: A composite is disclosed. The composite comprises a first conjugate of a polymer and a first phenol-containing moiety, and a second conjugate of a gelatin or collagen and a second phenol-containing moiety, wherein the polymer is selected so that the first conjugate is less cell-adhesive than the second conjugate, at least one of the first and second conjugates is crosslinked to form a matrix, and the composite comprises discrete regions that are rich in one of said first and second conjugates. A method of forming such composite is also disclosed. The method comprises mixing precursors for the first and second conjugates in a solution for forming said composite, and dispersing a catalyst in the solution to catalyze crosslinking of at least one of the first and second conjugates to form the matrix. The composite may be used to grow cells.Type: GrantFiled: April 21, 2011Date of Patent: March 5, 2019Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Li Shan Wang, Joo Eun Chung
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Publication number: 20190008830Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.Type: ApplicationFiled: July 18, 2018Publication date: January 10, 2019Inventors: Motoichi Kurisawa, Yongvongsoontorn Nunnarpas, Jackie Y. YING, Joo Eun CHUNG, Ki Hyun BAE, Min-Han TAN, Esther LEE
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Patent number: 10052389Abstract: The present disclosure relates to a polymeric system for release of an active agent, comprising a first polymeric phase containing the active agent, the first polymeric phase forming discrete regions of a set size range and being dispersed within a second polymeric phase comprising a cross-linked polymer-phenol conjugate for release of the active agent therein. The present disclosure further provides an injectable hydrogel comprising the disclosed polymeric system, a carrier for delivering a biologically active substance or a drug comprising the injectable hydrogel, and a method for producing the disclosed polymeric system.Type: GrantFiled: February 13, 2014Date of Patent: August 21, 2018Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Ki Hyun Bae, Fan Lee
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Patent number: 10052307Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.Type: GrantFiled: May 8, 2015Date of Patent: August 21, 2018Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Yongvongsoontorn Nunnarpas, Jackie Y Ying, Joo Eun Chung, Ki Hyun Bae, Min-han Tan, Esther Lee
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Publication number: 20170258926Abstract: The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system.Type: ApplicationFiled: May 8, 2015Publication date: September 14, 2017Inventors: Motoichi KURISAWA, Yongvongsoontorn NUNNARPAS, Jackie Y. YING, Joo Eun CHUNG, Ki Hyun BAE, Min-han TAN, Esther LEE
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Publication number: 20170258757Abstract: There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.Type: ApplicationFiled: May 18, 2017Publication date: September 14, 2017Inventors: Motoichi Kurisawa, Kun Liang, Susi Tan, Joo Eun Chung, Jackie Y. Ying
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Publication number: 20170216446Abstract: There is provided a polymer-flavonoid conjugate, or a pharmaceutically acceptable salt thereof, uses thereof, and methods of making thereof. The disclosed polymer-flavonoid conjugates may be useful in the therapeutic and/or prophylactic treatment of a joint condition in a subject.Type: ApplicationFiled: May 15, 2015Publication date: August 3, 2017Inventors: Motoichi KURISAWA, Fan LEE
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Patent number: 9687464Abstract: There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.Type: GrantFiled: March 11, 2011Date of Patent: June 27, 2017Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Kun Liang, Susi Tan, Joo Eun Chung, Jackie Y. Ying
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Patent number: 9439886Abstract: There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid. There is also provided a method for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid without the addition of an exogenous peroxide or peroxidase or without the addition of an exogenous peroxide. Hydrogels produced by such methods and methods of using the hydrogels are also described herein.Type: GrantFiled: April 27, 2015Date of Patent: September 13, 2016Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Fan Lee, Joo Eun Chung, Pui Yik Peggy Chan
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Publication number: 20160213787Abstract: There is provided polymer-flavonoid conjugates. Flavonoid-grafted and flavonoid-terminated polymer conjugates are disclosed according to the invention. The linkage of flavonoids to the polymers has been achieved via thiol linkages. The inventive processes allow for making of the conjugates in high yield avoiding complex purification steps. The conjugates can be easily autoxidized to hydrogels with uses in many biomedical applications where a higher stability of the flavonoid is necessary. The hydrogels can be potentially used as viscosupplement, anti-adhesion film or dermal filler.Type: ApplicationFiled: September 1, 2014Publication date: July 28, 2016Inventors: Motoichi KURISAWA, Ki Hyun BAE
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Publication number: 20160145580Abstract: There is provided a method for culturing a population of cancer stem cells. The method comprises introducing the cancer stem cells on or in a cell culture substrate, the cell culture substrate being in the form of a gel comprising a conjugate of a glycosaminoglycan and a substituted phenalkylamine.Type: ApplicationFiled: June 18, 2014Publication date: May 26, 2016Inventors: Motoichi KURISAWA, Atsushi YAMASHITA
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Publication number: 20160106706Abstract: There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. The resulting delivery vehicles may be used to deliver an anti-cancer agent to a cell.Type: ApplicationFiled: December 21, 2015Publication date: April 21, 2016Applicant: Agency for Science, Technology and ResearchInventors: Jackie Y. Ying, Joo Eun Chung, Motoichi Kurisawa
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Patent number: 9248200Abstract: There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. The resulting delivery vehicles may be used to deliver an anti-cancer agent to a cell.Type: GrantFiled: October 23, 2008Date of Patent: February 2, 2016Assignee: Agency for Science, Technology and ResearchInventors: Jackie Y. Ying, Joo Eun Chung, Motoichi Kurisawa
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Patent number: 9226899Abstract: There is presently provided a suspension of immiscible particles in a solution, wherein the particles comprise an agglomeration of a bioactive agent, for example an anti-cancer agent; and a plurality of conjugates of a hyaluronic acid and a flavonoid, for example a catechin-based flavonoid, wherein the particles are on average from about 15 nm to about 300 nm in diameter and wherein the bioactive agent is releasably retained in the particles by the flavonoid. The suspension is useful for delivery of the bioactive agent to cells, including cancer cells. There are also provided a therapeutic formulation comprising the suspension, as well as methods for using the suspension and therapeutic formulation, including for delivery of a bioactive agent to a cell and for treating a disease, including cancer.Type: GrantFiled: May 30, 2014Date of Patent: January 5, 2016Assignee: Agency for Science, Technology and ResearchInventors: Motoichi Kurisawa, Shengyong Ng, Joo Eun Chung