Abstract: A refrigerant pipe through which a flammable refrigerant flows is disposed in a machine chamber. An electric component including a substrate on which a heat-generating component is mounted is disposed in a fan chamber. In a working fluid channel, a working fluid is circulated between an evaporator and a condenser. The evaporator causes heat exchange between the heat-generating component and the working fluid. The condenser causes heat exchange between the flammable refrigerant flowing through the refrigerant pipe and the working fluid.

Abstract: A microscope image of a cultured cell cluster derived from a cancer specimen of a patient is acquired. A measured value of a gene expression level of the cluster is acquired. Based on the image, a morphological representation identifiably expressing, by a vector quantity of a plurality of dimensions, a morphological difference between a group of cell clusters cultured from the same cancer specimen and a group of cell clusters cultured from another cancer specimen is acquired. The acquired morphological representation is input to a function, which is obtained by fitting the measured value with respect to the morphological representation, to acquire a prediction value of the gene expression level. Prediction accuracy is estimated based on the prediction value and the measured value. Based on the estimated prediction accuracy, a gene related to a morphological change of the cell cluster is extracted as a gene candidate.

Abstract: A microscope image of a cultured cell cluster derived from a cancer specimen of a patient is acquired. A measured value of a gene expression level of the cluster is acquired. Based on the image, a morphological representation identifiably expressing, by a vector quantity of a plurality of dimensions, a morphological difference between a group of cell clusters cultured from the same cancer specimen and a group of cell clusters cultured from another cancer specimen is acquired. The acquired morphological representation is input to a function, which is obtained by fitting the measured value with respect to the morphological representation, to acquire a prediction value of the gene expression level. Prediction accuracy is estimated based on the prediction value and the measured value. Based on the estimated prediction accuracy, a gene related to a morphological change of the cell cluster is extracted as a gene candidate.

Abstract: An air conditioner is provided with a refrigerant circuit that has a first refrigerant path to which a compressor, a first utilization-side heat exchanger, a first expansion valve, and a heat source-side heat exchanger are connected in order. A control unit controls the compressor and the first expansion valve. When the control unit receives a request for high-temperature air that temporarily increases the temperature of the hot air blown out through the first utilization-side heat exchanger, the control unit changes the control of the first expansion valve so that the temperature of a refrigerant that flows through the first utilization-side heat exchanger increases.

Abstract: Provided is an air conditioner that can sufficiently increase a temperature of hot air when receiving a request for high-temperature air that temporarily increases the temperature of the hot air to be blown out. A refrigerant circuit has a first refrigerant path to which a compressor, a first utilization-side heat exchanger (121), a first expansion valve (131), and a heat source-side heat exchanger are connected in order. A control unit controls the compressor and the first expansion valve (131). When the control unit receives the request for high-temperature air that temporarily increases the temperature of the hot air blown out through the first utilization-side heat exchanger (121), the control unit changes the control of the first expansion valve (131) so that the temperature of a refrigerant that flows through the first utilization-side heat exchanger (121) increases.

Abstract: An air conditioning machine is provided by which refrigerant collected into an outdoor heat exchanger is suppressed from counter-flowing through a discharge hole of a compressor toward a side of an indoor heat exchanger after the end of a pump down operation. The air conditioning machine includes a refrigerant circuit, a refrigerant leakage sensor that senses leakage of the flammable refrigerant from the refrigerant circuit, and a control unit that carries out a pump down operation for accumulating the flammable refrigerant in the outdoor heat exchanger when the leakage of the flammable refrigerant is sensed. At the end of the pump down operation, the pump down operation control unit controls the compressor so that the compression member stops at a position where the compression member overlaps at least a portion of the discharge hole when viewed in an axial direction of the cylinder chamber.

Abstract: An air conditioning machine is provided by which a refrigerant collected into an outdoor heat exchanger can be suppressed from counter-flowing through a discharge hole of a compressor toward a side of an indoor heat exchanger in a refrigerant circuit after an end of a pump down operation. The air conditioning machine includes a refrigerant circuit, a refrigerant leakage sensing unit that senses leakage of the flammable refrigerant from the refrigerant circuit, and a pump down operation control unit that carries out the pump down operation for accumulating the flammable refrigerant in the outdoor heat exchanger in the refrigerant circuit when the refrigerant leakage sensing unit senses the leakage of the flammable refrigerant. The compressor includes a cylinder chamber, a compression member that is placed in the cylinder chamber and that compresses the flammable refrigerant, and a discharge hole through which the flammable refrigerant compressed in the cylinder chamber is discharged.

Abstract: The present invention revealed that by suppressing the expression of the WRN gene, the BLM gene, or the RecQ1 gene, which belong to the RecQ helicase family, apoptosis is induced in various cancer cells and their proliferation is suppressed. Compounds that suppress the expression of RecQ helicase family genes or the functions of RecQ helicase proteins are thought to have the activity of inducing apoptosis.

Abstract: The present inventors discovered that although suppressing expression of the RecQ1 gene, a RecQ helicase family gene, shows suppressive effects on cell proliferation in cancer cells, such effects are not observed in human TIG3 cells (a normal diploid fibroblast cell line), which are normal cells. Hence, the present inventors discovered that siRNAs against RecQ1 gene have cancer cell-specific cell proliferation-suppressing effects that are mediated by suppression of the expression of said gene.

Abstract: The present inventors discovered that inhibition of the expression of various genes associated with chromosome stabilization induces cancer cell-specific apoptosis and inhibits cell proliferation. Compounds that inhibit expression of a gene associated with chromosome stabilization or inhibit the function of a protein encoded by such a gene are thought to have cancer cell-specific apoptosis-inducing effects.

Abstract: The present inventors discovered that inhibition of the expression of various genes associated with chromosome stabilization induces cancer cell-specific apoptosis and inhibits cell proliferation. Compounds that inhibit expression of a gene associated with chromosome stabilization or inhibit the function of a protein encoded by such a gene are thought to have cancer cell-specific apoptosis-inducing effects.

Abstract: The present inventors discovered that inhibition of the expression of various genes associated with chromosome stabilization induces cancer cell-specific apoptosis and inhibits cell proliferation. Compounds that inhibit expression of a gene associated with chromosome stabilization or inhibit the function of a protein encoded by such a gene are thought to have cancer cell-specific apoptosis-inducing effects.

Abstract: The present inventors discovered that although suppressing expression of the RecQ1 gene, a RecQ helicase family gene, shows suppressive effects on cell proliferation in cancer cells, such effects are not observed in human TIG3 cells (a normal diploid fibroblast cell line), which are normal cells. Hence, the present inventors discovered that siRNAs against RecQ1 gene have cancer cell-specific cell proliferation-suppressing effects that are mediated by suppression of the expression of said gene.

Abstract: The present invention revealed that by suppressing the expression of the WRN gene, the BLM gene, or the RecQ1 gene, which belong to the RecQ helicase family, apoptosis is induced in various cancer cells and their proliferation is suppressed. Compounds that suppress the expression of RecQ helicase family genes or the functions of RecQ helicase proteins are thought to have the activity of inducing apoptosis.

Abstract: The present inventors discovered that inhibition of the expression of various genes associated with chromosome stabilization induces cancer cell-specific apoptosis and inhibits cell proliferation. Compounds that inhibit expression of a gene associated with chromosome stabilization or inhibit the function of a protein encoded by such a gene are thought to have cancer cell-specific apoptosis-inducing effects.

Abstract: The present inventors discovered that inhibition of the expression of various genes associated with chromosome stabilization induces cancer cell-specific apoptosis and inhibits cell proliferation. Compounds that inhibit expression of a gene associated with chromosome stabilization or inhibit the function of a protein encoded by such a gene are thought to have cancer cell-specific apoptosis-inducing effects.

Abstract: The present invention revealed that by suppressing the expression of the WRN gene, the BLM gene, or the RecQ1 gene, which belong to the RecQ helicase family, apoptosis is induced in various cancer cells and their proliferation is suppressed. Compounds that suppress the expression of RecQ helicase family genes or the functions of RecQ helicase proteins are thought to have the activity of inducing apoptosis.

Abstract: The present inventors discovered that although suppressing expression of the RecQ1 gene, a RecQ helicase family gene, shows suppressive effects on cell proliferation in cancer cells, such effects are not observed in human TIG3 cells (a normal diploid fibroblast cell line), which are normal cells. Hence, the present inventors discovered that siRNAs against RecQ1 gene have cancer cell-specific cell proliferation-suppressing effects that are mediated by suppression of the expression of said gene.

Abstract: The present inventors discovered that inhibition of the expression of various genes associated with chromosome stabilization induces cancer cell-specific apoptosis and inhibits cell proliferation. Compounds that inhibit expression of a gene associated with chromosome stabilization or inhibit the function of a protein encoded by such a gene are thought to have cancer cell-specific apoptosis-inducing effects.

Abstract: The present invention revealed that by suppressing the expression of the WRN gene, the BLM gene, or the RecQ1 gene, which belong to the RecQ helicase family, apoptosis is induced in various cancer cells and their proliferation is suppressed. Compounds that suppress the expression of RecQ helicase family genes or the functions of RecQ helicase proteins are thought to have the activity of inducing apoptosis.