Abstract: An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, and usage of them.

Abstract: An artificial catalyst system substitutable for an in vivo histone acylation function has been successfully established by such an approach of synthetic chromosome acylation using a combination of a chromosome-localizable nucleophilic catalyst and a chromosome-localizable acylating agent.

Abstract: There are provided a compound capable of being a novel ligand allowing regioselective borylation to be performed in the aromatic borylation reaction, and a catalyst using the same compound.

Abstract: Provided is a novel compound which has an excellent A? aggregation inhibitory effect and is useful as a pharmaceutical. An amide compound represented by the formula (1) or a salt thereof, wherein Z represents CH or N; A and B are the same or different and each represents —CH2—, —O—, —S—, or —NH—; R1 and R2 are the same or different and each represents a branched alkyl group, a branched alkenyl group, an optionally substituted aromatic hydrocarbon group, an optionally substituted aralkyl group, an optionally substituted cycloalkyl group, or an optionally substituted aromatic heterocyclic group; and R3 represents a branched alkyl group, a branched alkenyl group, an optionally substituted cycloalkyl group, or an optionally substituted aralkyl group.

Abstract: It is an object of the present invention to provide a mutant streptavidin with a reduced affinity for natural biotin, and also to provide a modified biotin having a high affinity for the mutant streptavidin with a reduced affinity for natural biotin. According to the present invention, there is provided a reagent kit for use in treatments or diagnoses, which comprises: (a) a mutant streptavidin with a reduced affinity for natural biotin or biocytin; and a modified biotin having a high affinity for the above-described mutant streptavidin.

Abstract: The invention provides an A? peptide aggregation inhibitor, an A? peptide toxicity reducing agent, and a preventive and/or therapeutic agent for Alzheimer's disease. The oxidized A? peptide in which one or more amino acid residues of A? peptide have been oxidized (excluding an oxidized A? peptide in which only Met has been oxidized).

Abstract: Provided is a novel compound which has excellent inhibitory activity for A? aggregation, and which is useful as a drug.

Abstract: A reagent for imaging an advancing intracellular acetylation, for example, an acetylation that is advanced by the action of acetyl-CoA in the mitochondria, at high sensitivity and high efficiency, which comprises a combination of a rhodamine derivative that is substantially non-fluorescent before being acetylated, and emits strong fluorescence after being acetylated, and an acylation catalyst and/or an acylation reaction-promoting agent.

Abstract: Disclosed is a novel asymmetric ligand which can be synthesized by a short process at low cost and is capable of exhibiting higher catalytic activity and enantioselectivity than the conventional ligands derived from sugars. Also disclosed are a method for producing such an asymmetric ligand, and a catalyst using such an asymmetric ligand. Specifically disclosed is a ligand represented by the general formula I below or the like. (In the formula, R1 and R2 independently represent 0-5 substituents; X represents P, As or N; m represents an integer of 0-7; n represents an integer of 0-3; A1-A4 independently represent hydrogen, fluorine, chlorine, bromine, benzoyl or acetyl, or alternatively A2 and A3 combine together to form a ring.

Abstract: A process for producing an alcohol or a silyl ether thereof of formula (4): wherein R1 represents a hydrocarbon, a heterocyclic, or an alkoxycarbonyl group; R2 represents hydrogen or CO2R; X represents an aryl or an alkenyl group of formula (3): and R8 represents hydrogen or a silyl residue, by reacting a compound R1(C?O)R2 with a silane (R3)2R4Si—X, wherein R3 and R4 each represents an alkyl, an alkoxy, or an aryl group; in the presence of (i) a catalyst component containing copper fluoride or a catalyst component containing a copper compound and a fluoride and (ii) a bidentate phosphine compound or in the presence of a complex obtained from the foregoing components.

Abstract: Disclosed is a novel asymmetric ligand which can be synthesized by a short process at low cost and is capable of exhibiting higher catalytic activity and enantioselectivity than the conventional ligands derived from sugars. Also disclosed are a method for producing such an asymmetric ligand, and a catalyst using such an asymmetric ligand. Specifically disclosed is a ligand represented by the general formula I below or the like. (In the formula, R1 and R2 independently represent 0-5 substituents; X represents P, As or N; m represents an integer of 0-7; n represents an integer of 0-3; A1-A4 independently represent hydrogen, fluorine, chlorine, bromine, benzoyl or acetyl, or alternatively A2 and A3 combine together to form a ring.

Abstract: A method of manufacturing a cyano compound by reacting a carbonyl compound with a nitrile compound having at least one ?-hydrogen atom in the presence of a ligand and a metal compound of formula (III), MX??(III) wherein M is a copper atom or a silver atom, and X is an alkoxy group, an alkyl group, an aryl group or an anionic residue.

Abstract: A process for producing an alcohol or a silyl ether thereof of formula (4): wherein R1 represents a hydrocarbon, a heterocyclic, or an alkoxycarbonyl group; R2 represents hydrogen or CO2R; X represents an aryl or an alkenyl group of formula (3): and R8 represents hydrogen or a silyl residue, by reacting a compound R1(C?O)R2 with a silane (R3)2R4Si—X, wherein R3 and R4 each represents an alkyl, an alkoxy, or an aryl group; in the presence of (i) a catalyst component containing copper fluoride or a catalyst component containing a copper compound and a fluoride and (ii) a bidentate phosphine compound or in the presence of a complex obtained from the foregoing components.

Abstract: A method of manufacturing a cyano compound by reacting a carbonyl compound with a nitrile compound having at least one ?-hydrogen atom in the presence of a ligand and a metal compound of formula (III), MX??(III) wherein M is a copper atom or a silver atom, and X is an alkoxy group, an alkyl group, an aryl group or an anionic residue.

Abstract: A ligand expressed by a general formula (1) in claim 1, wherein R1, R2 and R3 denote substituting groups on aromatic rings, X is P or As, and n is 1 to 3.

Abstract: An oxybutynin and its derivatives are produced by reacting a phenylketone with a silylcyanide in the presence of a specified asymmetric catalyst to obtain a siloxynitrile, and then reacting the siloxynitrile with a reducing agent and oxidizing the resulting aldehyde, or subjecting the siloxynitrile to a hydrolysis.

Abstract: A ligand expressed by a general formula (1) in claim 1, wherein R1, R2 and R3 denote substituting groups on aromatic rings, X is P or As, and n is 1 to 3.

Abstract: An optically active binaphthyl compound of the formula (1): wherein R1 is a C1-6 alkyl group, an aryl group or an aryl C1-6 alkyl group, X is an oxygen atom or a sulfur atom, R2 is a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group or a halogen atom, each of L1 and L2 is a hydrogen atom, or L1 and L2 together form MY wherein M is a rare earth element or a Group 13 element, and Y is a C1-6 alkoxy group, a C1-6 alkylcarbonyloxy group or a halogen atom, and m is an integer of from 1 to 3.