Abstract: Provided is a pharmaceutical composition for treating a renal disease. The pharmaceutical composition for treating a renal disease comprises a mineralocorticoid receptor antagonist.

Abstract: A vehicle end structure comprises a pair of side frame members disposed at a longitudinal end portion adjacent to a cabin and a suspension support member disposed below the side frame members in a portion adjacent to the cabin. A pair of pressure receiving members is provided that are fixedly coupled to the suspension support member and extend toward a longitudinal end of the vehicle in direction substantially parallel to the side frame members. Thus, the vehicle end structure is configured and arranged to minimize the influence on the cabin even when collision energy is inputted from the longitudinal end of the vehicle.

Abstract: A method of manufacturing a torsion bar includes a first shaping step of reducing a diameter of a round bar steel material according to cold drawing work so as to have a hardness including an inside through a surface layer of 320 or more to 450 or less by Vickers hardness (HV), and a second shaping step of cutting a midway area of the steel material in the longitudinal direction so as to obtain a spring portion.

Abstract: A vehicle end structure comprises a pair of side frame members disposed at a longitudinal end portion adjacent to a cabin and a suspension support member disposed below the side frame members in a portion adjacent to the cabin. A pair of pressure receiving members is provided that are fixedly coupled to the suspension support member and extend toward a longitudinal end of the vehicle in direction substantially parallel to the side frame members. Thus, the vehicle end structure is configured and arranged to minimize the influence on the cabin even when collision energy is inputted from the longitudinal end of the vehicle.

Abstract: A method of manufacturing a torsion bar includes a first shaping step of reducing a diameter of a round bar steel material according to cold drawing work so as to have a hardness including an inside through a surface layer of 320 or more to 450 or less by Vickers hardness (HV), and a second shaping step of cutting a midway area of the steel material in the longitudinal direction so as to obtain a spring portion.

Abstract: An endosseous implant having a mesh pore structure including at least an embedding portion to be embedded in a living bone tissue, the embedding portion containing any one of a single sheet of platelike body itself and a desired shape of body obtained by working the platelike body, the platelike body comprising any one of a single metal mesh sheet and a laminate of a plurality of metal mesh sheets formed into one body by mechanical bonding or by sintering, the laminate having a multiplicity of mesh pores passing through the embedding portion, whereby the embedding portion provides a mesh pore structure adapted to permit into the mesh pores the ingrowth and penetration of a fibrous tissue alone out of three kinds of bone, osteoid, and fibrous tissues or not less than two tissues inclusive of the fibrous tissue.

Abstract: An endosseous implant including at least an embedding portion to be embedded in a living tissue, the embedding portion comprising any of a platelike body itself and a desired shape of body obtained by working the platelike body, the platelike body having orderly or disorderly a plurality of substantially straight tubular channels passing through the thickness of the platelike body for permitting the ingrowth and penetration of the adjacent bone tissue therein, the tubular channels including at least two kinds of three different pore diameters of large, medium, and small pore diameters respectively for permitting the ingrowth and penetration of a bone tissue, osteoid tissue, and fibrous tissue, whereby a polycapillary structure is built by the ingrowth and penetration of the at least two of the three kinds of tissues which pass through the thickness of the platelike body after the implantation.

Abstract: A frameless and coreless porous endosseous implant comprising a porous sintered metal layer (2) having a range of relatively large pores and porous sintered metal layers having a range of relatively small pores and laminated into one body by sintering integrally with the layer on either side thereof, or a porous singered metal layer having a range of relatively small pores and porous sintered metal layers having a range of relatively large pores and laminated into one body by sintering integrally with the layer on either side thereof, whereby the three layers each permit the ingrowth and penetration out of two or more kinds out of fibrous tissue, osteoid tissue and bone tissue in the pores thereof.

Abstract: An endosseous implant having a mesh pore structure including at least an embedding portion to be embedded in a living bone tissue, the embedding portion being a single sheet of a platelike body or a desired shape of body obtained by working the platelike body. The platelike body can be a single metal mesh sheet or a laminate of a plurality of metal mesh sheets formed into one body by mechanical bonding or by sintering, the laminate having a multiplicity of mesh pores passing through the embedding portion, whereby the embedding portion provides a mesh pore structure adapted to permit into the mesh pores the ingrowth and penetration of a fibrous tissue along out of three kinds of bone, osteoid, and fibrous tissues or not less than two tissues inclusive of the fibrous tissue.