Abstract: [Object] To provide a steel sheet for carburizing that demonstrates improved ductility, and a method for manufacturing the same. [Solution] A steel sheet consisting of, in mass %, C: more than or equal to 0.02%, and less than 0.30%, Si: more than or equal to 0.005%, and less than 0.5%, Mn: more than or equal to 0.01%, and less than 3.0%, P: less than or equal to 0.1%, S: less than or equal to 0.1%, sol. Al: more than or equal to 0.0002%, and less than or equal to 3.0%, N: less than or equal to 0.2%, Ti: more than or equal to 0.010%, and less than or equal to 0.150%, and the balance: Fe and impurities, in which the number of carbides per 1000 ?m2 is 100 or less, percentage of number of carbides with an aspect ratio of 2.0 or smaller is 10% or larger relative to the total carbides, average equivalent circle diameter of carbide is 5.0 ?m or smaller, and average crystal grain size of ferrite is 10 ?m or smaller.

Abstract: The present invention aims to obtain an anti-repulsive guidance molecule a (RGMa) antibody having a high binding activity and few side effects which can be used as a medicine for preventing, treating, or preventing the relapse of neurological or immunological diseases. The problem is solved by providing an isolated RGMa binding protein which does not inhibit binding between RGMa and neogenin but neutralizes the neurite outgrowth inhibiting activity of RGMa, preferably by providing an anti-RGMa antibody which has complementarity determining regions having amino acid sequences of SEQ ID NOS: 30-35 or SEQ ID NOS: 36-40 in Sequence Listing, and SFG.

Abstract: [Object] To provide a steel sheet for carburizing having further improved formability and toughness after carburizing, and a method for manufacturing the same. [Solution] A steel sheet consisting of, in mass %, C: more than or equal to 0.02%, and less than 0.30%, Si: more than or equal to 0.005%, and less than or equal to 0.5%, Mn: more than or equal to 0.01%, and less than or equal to 3.0%, P: less than or equal to 0.1%, S: less than or equal to 0.1%, sol. Al: more than or equal to 0.0002%, and less than or equal to 3.0%, N: more than or equal to 0.0001, and less than or equal to 0.035%, and the balance: Fe and impurities, in which average crystal grain size of ferrite is smaller than 10 ?m, average equivalent circle diameter of carbide is 5.0 ?m or smaller, percentage of number of carbides with an aspect ratio of 2.

Abstract: The present invention aims to obtain an anti-repulsive guidance molecule a (RGMa) antibody having a high binding activity and few side effects which can be used as a medicine for preventing, treating, or preventing the relapse of neurological or immunological diseases. The problem is solved by providing an isolated RGMa binding protein which does not inhibit binding between RGMa and neogenin but neutralizes the neurite outgrowth inhibiting activity of RGMa, preferably by providing an anti-RGMa antibody which has complementarity determining regions having amino acid sequences of SEQ ID NOS: 30-35 or SEQ ID NOS: 36-40 in Sequence Listing, and SFG.

Abstract: [Object] To provide a steel sheet for carburizing that demonstrates improved extreme deformability prior to carburizing, and a method for manufacturing the same. [Solution] A steel sheet consisting of, in mass %, C: more than or equal to 0.02%, and less than 0.30%, Si: more than or equal to 0.005%, and less than 0.5%, Mn: more than or equal to 0.01%, and less than 3.0%, P: less than or equal to 0.1%, S: less than or equal to 0.1%, sol. Al: more than or equal to 0.0002%, and less than or equal to 3.0%, N: less than or equal to 0.2%, and the balance: Fe and impurities, in which average value of X-ray random intensity ratio, assignable to an orientation group of ferrite crystal grain ranging from {100}<011> to {223}<110>, is 7.0 or smaller, average equivalent circle diameter of carbide is 5.0 ?m or smaller, percentage of number of carbides with an aspect ratio of 2.

Abstract: The present invention provides steel sheet excellent in cold formability and ductility after heat treatment and a method for production thereof. The steel sheet of the present invention is steel sheet which has a chemical composition containing, by mass %, C: 0.10 to 0.40%, Si: 0.30 to 1.00%, Mn: 0.30 to 1.00%, Al: 0.001 to 0.10%, P: 0.0001 to 0.02%, and S: 0.0001 to 0.01% and having a balance of Fe and impurities, which steel sheet characterized in that a ratio (B/A) of the number of carbides at the ferrite grain boundaries (B) to the number of carbides inside the ferrite grains (A) is over 1, a ferrite grain size is 5 ?m to 50 ?m, an average grain size of carbides is 0.4 ?m to 2.0 ?m, a pearlite area ratio is 6% or less, and a Vicker's hardness is 120 HV to 170 HV.

Abstract: [Object] To provide a steel sheet for carburizing that demonstrates improved extreme deformability prior to carburizing, and a method for manufacturing the same. [Solution] A steel sheet consisting of, in mass %, C: more than or equal to 0.02%, and less than 0.30%, Si: more than or equal to 0.005%, and less than 0.5%, Mn: more than or equal to 0.01%, and less than 3.0%, P: less than or equal to 0.1%, S: less than or equal to 0.1%, sol. Al: more than or equal to 0.0002%, and less than or equal to 3.0%, N: less than or equal to 0.2%, and the balance: Fe and impurities, in which average value of X-ray random intensity ratio, assignable to an orientation group of ferrite crystal grain ranging from {100}<011> to {223}<110>, is 7.0 or smaller, average equivalent circle diameter of carbide is 5.0 ?m or smaller, percentage of number of carbides with an aspect ratio of 2.

Abstract: [Object] To provide a steel sheet for carburizing that demonstrates improved ductility, and a method for manufacturing the same. [Solution] A steel sheet consisting of, in mass %, C: more than or equal to 0.02%, and less than 0.30%, Si: more than or equal to 0.005%, and less than 0.5%, Mn: more than or equal to 0.01%, and less than 3.0%, P: less than or equal to 0.1%, S: less than or equal to 0.1%, sol. Al: more than or equal to 0.0002%, and less than or equal to 3.0%, N: less than or equal to 0.2%, Ti: more than or equal to 0.010%, and less than or equal to 0.150%, and the balance: Fe and impurities, in which the number of carbides per 1000 ?m2 is 100 or less, percentage of number of carbides with an aspect ratio of 2.0 or smaller is 10% or larger relative to the total carbides, average equivalent circle diameter of carbide is 5.0 ?m or smaller, and average crystal grain size of ferrite is 10 ?m or smaller.

Abstract: The present invention aims to obtain an anti-repulsive guidance molecule a (RGMa) antibody having a high binding activity and few side effects which can be used as a medicine for preventing, treating, or preventing the relapse of neurological or immunological diseases. The problem is solved by providing an isolated RGMa binding protein which does not inhibit binding between RGMa and neogenin but neutralizes the neurite outgrowth inhibiting activity of RGMa, preferably by providing an anti-RGMa antibody which has complementarity determining regions having amino acid sequences of SEQ ID NOS: 30-35 or SEQ ID NOS: 36-40 in Sequence Listing, and SFG.

Abstract: The present invention aims to obtain an anti-repulsive guidance molecule a (RGMa) antibody having a high binding activity and few side effects which can be used as a medicine for preventing, treating, or preventing the relapse of neurological or immunological diseases. The problem is solved by providing an isolated RGMa binding protein which does not inhibit binding between RGMa and neogenin but neutralizes the neurite outgrowth inhibiting activity of RGMa, preferably by providing an anti-RGMa antibody which has complementarity determining regions having amino acid sequences of SEQ ID NOS: 30-35 or SEQ ID NOS: 36-40 in Sequence Listing, and SFG.

Abstract: Low carbon steel plate excellent impact resistance characteristics after carburizing and quenching and after tempering, characterized by having a predetermined chemical composition, an average grain size of carbides of 0.4 ?m to 2.0 ?m, an area ratio of pearlite of 6% or less, a ratio of a number of carbides at the ferrite grain boundaries to the number of carbides inside the ferrite grains of over 1, and a Vickers hardness of 100HV to 180HV.

Abstract: A steel plate improved in formability and wear resistance, having a predetermined chemical composition, having a metal structure of the steel plate having a ratio of number of carbides at ferrite grain boundaries with respect to a number of carbides in ferrite grains of over 1 and having a ferrite grain size of 5 ?m to 50 ?m, and having a Vickers hardness of steel plate of 100 HV to 170 HV.

Abstract: A steel sheet improved in hardenability and material formability having a predetermined chemical composition, characterized in that, in the metal structure of the steel sheet, an average grain size of carbides is 0.4 ?m to 2.0 ?m, an area ratio of pearlite is 6% or less, when a number of carbides in ferrite grains is A and a number of carbides at ferrite grain boundaries is B, B/A>l, and when an X-ray diffraction intensity at {211}<011>at a plane of a part of ½ sheet thickness of the steel sheet is denoted by “I1” and an X-ray diffraction intensity at {100}<011>is denoted by “I0”, I1/I0<1 is satisfied, and the steel sheet has a Vickers hardness of 100 HV to 150 HV.

Abstract: The present invention provides steel sheet excellent in cold formability and ductility after heat treatment and a method for production thereof. The steel sheet of the present invention is steel sheet which has a chemical composition containing, by mass %, C: 0.10 to 0.40%, Si: 0.30 to 1.00%, Mn: 0.30 to 1.00%, Al: 0.001 to 0.10%, P: 0.0001 to 0.02%, and S: 0.0001 to 0.01% and having a balance of Fe and impurities, which steel sheet characterized in that a ratio (B/A) of the number of carbides at the ferrite grain boundaries (B) to the number of carbides inside the ferrite grains (A) is over 1, a ferrite grain size is 5 ?m to 50 ?m, an average grain size of carbides is 0.4 ?m to 2.0 ?m, a pearlite area ratio is 6% or less, and a Vicker's hardness is 120 HV to 170 HV.

Abstract: The present invention provides a steel sheet having an excellent cold workability during forming and a method for producing the same. The steel sheet of the present invention is characterized in that: (a) the ratio of the number of carbides at the ferrite grain boundary to the number of carbides in the ferrite grain exceeds 1, (b) the ferrite grain diameter is 5 ?m or more and 50 ?m or less, (c) the in-plane anisotropy |?r| of the r value is 0.2 or less, (d) the Vickers hardness is 100 HV or more and 150 HV or less, (e) the random intensity ratio of the {311} <011> orientation at the ½-thickness portion of the steel sheet is 3.0 or less.

Abstract: The present invention aims to obtain an anti-repulsive guidance molecule a (RGMa) antibody having a high binding activity arid few side effects which can be used as a medicine for preventing, treating, or preventing the relapse of neurological or immunological diseases. The problem is solved by providing an isolated RGMa binding protein which does not inhibit binding between RGMa and neogenin but neutralizes the neurite outgrowth inhibiting activity of RGMa, preferably by providing an anti-RGMa antibody which has complementarity determining regions having amino acid sequences of SEQ ID NOS: 30-35 or SEQ ID NOS: 36-40 in Sequence Listing, and SFG.

Abstract: The present invention provides a pharmaceutical formulation comprising paraoxonase (PON), a purification and stabilization method of PON, and an agent for prophylactic and/or therapeutic treatment of a disease resulting from ischemia reperfusion and/or cerebral infarction containing PON as an active ingredient.

Abstract: The present invention provides a pharmaceutical formulation comprising paraoxonase (PON), a purification and stabilization method of PON, and an agent for prophylactic and/or therapeutic treatment of a disease resulting from ischemia reperfusion and/or cerebral infarction containing PON as an active ingredient.

Abstract: The present invention provides a pharmaceutical formulation comprising paraoxonase (PON), a purification and stabilization method of PON, and an agent for prophylactic and/or therapeutic treatment of a disease resulting from ischemia reperfusion and/or cerebral infarction containing PON as an active ingredient.

Abstract: A method for producing an immunoglobulin preparation for intravenous injection, which comprises the steps of: fractionating an immunoglobulin-containing solution with 4 to 10 w/v% of polyethylene glycol having a molecular weight of from 1,000 to 10,000, at a pH value of from 4.5 to 6.5, an ionic strength of from 0.0001 to 0.1 M and a temperature of from 0 to 4° C. to recover a supernatant fraction; and concentrating the supernatant fraction at a pH of from 3.5 to 5.0.