Patents by Inventor Motoyuki Hagihara

Motoyuki Hagihara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing alkynylketone derivative
    Patent number: 9951051
    Abstract: The present invention relates to a Sonogashira-Carbonylation reaction using two types of gas, as well as novel crystals which can control a heat of the said reaction and the process of producing the same. In addition, the present invention relates to a ligand (additive) to prevent the deactivation of a palladium catalyst.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: April 24, 2018
    Assignee: SHIONOGI & CO., LTD.
    Inventors: Genta Tadano, Fumiya Ikarashi, Kazuya Okamoto, Toshikatsu Maki, Motoyuki Hagihara
  • PROCESS FOR PRODUCING ALKYNYLKETONE DERIVATIVE
    Publication number: 20170197943
    Abstract: The present invention relates to a Sonogashira-Carbonylation reaction using two types of gas, as well as novel crystals which can control a heat of the said reaction and the process of producing the same. In addition, the present invention relates to a ligand (additive) to prevent the deactivation of a palladium catalyst.
    Type: Application
    Filed: May 28, 2015
    Publication date: July 13, 2017
    Applicant: Shionogi & Co., Ltd.
    Inventors: Genta TADANO, Fumiya IKARASHI, Kazuya OKAMOTO, Toshikatsu MAKI, Motoyuki HAGIHARA
  • PROCESS FOR PRODUCTION OF QUINAZOLINE DERIVATIVE
    Publication number: 20110257391
    Abstract: A process for preparing a compound (III) is provided, in which the compound (III) is prepared from a methoxycarbonyl derivative through a methoxyamide derivative. These two reaction steps are continuously carried out and substantially the same as one step. The compound (III) is useful as a synthetic intermediate for preparing a dual tyrosine kinase inhibitor and can be conveniently prepared in high yield according to the present invention.
    Type: Application
    Filed: December 24, 2009
    Publication date: October 20, 2011
    Inventors: Motoyuki Hagihara, Shoji Shinomoto