Abstract: A control system for inducing transgene expression by means of D-2-hydroxyglutarate (D-2-HG), which relates to the technical fields of synthetic biology, gene therapy and cell immunity. A sensing object of the control system is D-2-HG; and the control system is classified into a control system for inducing transgene expression by means of high-concentration D-2-HG (HGind-H) and a control system for inducing transgene expression by means of low-concentration D-2-HG (HGind-L). The control system includes a recombinant transcriptional repressor, a D-2-HG inducible promoter and a sequence to be transcribed. According to the present invention, the system is used to control a diagnostic gene circuit, a suicide gene circuit and an immune cell therapeutic gene circuit that respond to a tumor metabolite D-2-HG, thereby developing living cell sensors, suicide gene therapy products and cell therapy products with D-2-HG as key information.

Abstract: The present disclosure provides a method and apparatus for improving display uniformity of a volume holographic optical waveguide. Specifically, the volume holographic optical waveguide includes a switchable grating structure, a partial region on the switchable grating structure is directionally selected as a coupling region thereof, such that a light source can only be coupled out of the coupling region at the maximum diffraction efficiency thereof. The coupling region on the switchable grating structure is continuously switched, and the time in which the coupling region covers all the regions is made not more than the visual retention time of human eyes.

Abstract: A DC-to-DC converter control method and system based on backstepping super-twisting, a device, and a storage medium are disclosed, the method including: constructing a state-space model of a DC-to-DC converter according to Kirchhoff's laws and a topological structure of the DC-to-DC converter; acquiring initial PWM wave control information by using a backstepping control algorithm in an inner current loop of the DC-to-DC converter according to the state-space model; processing the initial PWM wave control information by using a super-twisting sliding mode control algorithm in an outer voltage loop of the DC-to-DC converter based on the state-space model to obtain final PWM wave control information; and regulating an operation state of the DC-to-DC converter with the final PWM wave control information.

Abstract: A volume holographic grating, a method for formulating a grating vector distribution formulation thereof, and a method and apparatus for manufacturing the volume holographic grating. The grating vector distribution is estimated by sampling a position of an eye movement range effective region of a plurality of sub-fields of view and a grating vector, matching with Bragg diffraction conditions, of a ray thereof, without considering the diffraction of ineffective rays that ultimately enter beyond the eye movement range, such that most of the effective rays with different incident angles have higher diffraction efficiency on the volume holographic grating, which ensures the overall brightness uniformity of the output beams and extend the field of view.

Abstract: Disclosed are a volume holographic optical diffusion element and a manufacturing method and apparatus thereof. A first lens assembly is provided between a first diffusion element and a holographic photosensitive material layer. A real image of the first diffusion element is projected onto the holographic photosensitive material layer by the first lens assembly. Among rays of light emitted by random point light sources generated when the first diffusion element is irradiated with signal light, only rays within a certain angle range can pass through the first lens assembly due to the constraint of the entrance pupil aperture of the first lens assembly, so that rays of light on a rear side of the real image projected onto the holographic photosensitive material layer have a limited divergence angle.

Abstract: A DC-to-DC converter control method and system based on backstepping super-twisting, a device, and a storage medium are disclosed, the method including: constructing a state-space model of a DC-to-DC converter according to Kirchhoff's laws and a topological structure of the DC-to-DC converter; acquiring initial PWM wave control information by using a backstepping control algorithm in an inner current loop of the DC-to-DC converter according to the state-space model; processing the initial PWM wave control information by using a super-twisting sliding mode control algorithm in an outer voltage loop of the DC-to-DC converter based on the state-space model to obtain final PWM wave control information; and regulating an operation state of the DC-to-DC converter with the final PWM wave control information.

Abstract: Disclosed are an image processing method and apparatus, and an image processing device. According to the image processing method and apparatus, and the image processing device, an infrared binocular camera collects images formed when a measured object is illuminated by a speckle pattern projected by a projection assembly to obtain a first image collected by a first camera and a second image collected by a second camera; and three-dimensional data of the measured object is determined according to a pair of images constituted by the first image and the second image. By means of the method, three-dimensional data of a measured object can be relatively accurately obtained through measurement, thereby improving precision and accuracy of measurement, and also precision requirements for a projection assembly are low, so that costs can be lowered.

Abstract: Disclosed are an image processing method and apparatus, and an image processing device. According to the image processing method and apparatus, and the image processing device, an infrared binocular camera collects images formed when a measured object is illuminated by a speckle pattern projected by a projection assembly to obtain a first image collected by a first camera and a second image collected by a second camera; and three-dimensional data of the measured object is determined according to a pair of images constituted by the first image and the second image. By means of the method, three-dimensional data of a measured object can be relatively accurately obtained through measurement, thereby improving precision and accuracy of measurement, and also precision requirements for a projection assembly are low, so that costs can be lowered.

Abstract: Newly synthesized thiourea-modified 3-chloro-4-fluoroanilino-quinazoline derivatives have been studied as terminal carrier ligands in linear gold(I) complexes. The molecules mimic the tyrosine kinase inhibitor gefitinib (by computational docking experiments). Thiourea groups were either directly attached to quinazoline-C6 or linked to this position via a flexible ethylamino chain. One compound tested acts as a thiourea-S/quinazoline-N1 mixed-donor ligand, giving an unusual dinuclear complex as determined by X-ray crystallography and/or electrospray mass spectrometry. One compound formed the desired stable linear complex. The biological activity of the carrier ligands and corresponding gold(I) complexes was studied in NCI-H460 and NCI-H1975 lung cancer cells. One compound that was tested partially overcomes resistance to gefitinib in NCI-H1975 (with IC50 values of 1.7 and 30 ?M, respectively), and the corresponding gold complex (13) maintains activity in the low-micromolar concentration range.

Abstract: Newly synthesized thiourea-modified 3-chloro-4-fluoroanilino-quinazoline derivatives have been studied as terminal carrier ligands in linear gold(I) complexes. The molecules mimic the tyrosine kinase inhibitor gefitinib (by computational docking experiments). Thiourea groups were either directly attached to quinazoline-C6 or linked to this position via a flexible ethylamino chain. One compound tested acts as a thiourea-S/quinazoline-N1 mixed-donor ligand, giving an unusual dinuclear complex as determined by X-ray crystallography and/or electrospray mass spectrometry. One compound formed the desired stable linear complex. The biological activity of the carrier ligands and corresponding gold(I) complexes was studied in NCI-H460 and NCI-H1975 lung cancer cells. One compound that was tested partially overcomes resistance to gefitinib in NCI-H1975 (with IC50 values of 1.7 and 30 ?M, respectively), and the corresponding gold complex (13) maintains activity in the low-micromolar concentration range.